POSTPONED: CMCB Life Sciences Seminar: Dissecting lineage specification in the brain using single-cell epigenomics

Publications: 

Boxer LD, Renthal W, Greben AW, Whitwam T, Silberfeld A, Stroud H, Li E, Yang MG, Kinde B, Griffith EC, Bonev B, Greenberg ME.  MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes. Mol Cell (2020) Jan 16;77(2):294-309.e9

Bonev B.#, Cohen N., Szabo Q., Fritsch L., Papadopoulos G., Lubling Y., Xu X., Lv X., Hugnot JP, Tanay A. & Cavalli G#. Multiscale3D genome rewiring during mouse neural development. Cell (2017)171, 557.e1–557.e24.

Bonev B.& Cavalli G. Organization and function of the 3D genome. Nature Reviews Genetics (2016)17,661–678

Bonev B.,Stanley P. & Papalopulu, N. microRNA-9 modulates Hes1 ultradian oscillations by forming a negative feedback loop. Cell Reports (2012)2(1): 10-18.

Bonev B., Pisco A. & Papalopulu, N. MicroRNA-9 Reveals Regional Diversity of Neural Progenitors along the Anterior-Posterior Axis.Developmental Cell (2011)20, 19-32

Abstract:

The Bonev Lab focuses on decoding the epigenetic mechanisms of gene regulation in the cortex and how they control temporal and spatial cellular identity in development and evolution. To accomplish this, we study the interplay between transcription factors, 3D nuclear organization and gene expression in vivo and using cerebral organoids. Our research is highly interdisciplinary and combines developmental neurobiology, single cell –omics, mouse genetics, CRISPR-based techniques and computational biology.