Biofunctionalized Surfaces
| Teacher | Prof. Dr. Dieter Scharnweber & Dr. Susanne Bierbaum |
| Guest teacher | PD Dr. habil. Vera Hintze, Dr. Cornelia Wolf-Brandstetter, |
| Contact | Frau Marita Keil |
| Teaching Load | 2 SWS Teachung, self-study |
| Exam |
for MS students and other students from Mechanical Engineering written exam, 90 minutes; Date: February 7th, 2019, 9:00 a.m. in the MBC room 301 for all other students oral exam, single, 20 minutes Date. February 7th, starting 1:00 p.m. in room 108 of the MBC no resources allowed |
| Date/Cycle |
Starting date 12.10.2018; 5. DS The lecture on January 18th will last only about 60 minutes. Thus, the student presentations will start already about 4:00 p.m. each winter term |
| Scripts | The download address will be given in the first lecture. |
| Content |
Major topic of the course are the processes occurring when a biomaterials comes into contact with a biological system. Within the course both the reasons and the potential biological consequences of these interactions will be discussed together with possibilities to influence these interactions by the design of the biomaterials surface. Additionally the course will focus on the relevant fundamental aspects of cell communication and cellular reaction to biochemical and biophysical properties of their microenvironment.
Different methods for a defined design of biomaterials surface properties will be discussed with special attention paid to
● the biological background,
● the methods to generate the surface property profile,
● the biologically wanted surface property as well as
● relevant results from cell biological experiments, animal testing, and clinical trials.
This includes (i) methods to create defined surface morphologies via physical and chemical processing, (ii) physical and chemical modifications of surface properties, (iii) inorganic coating systems, and (iv) the whole area of BioSurface Engineering, i.e. the biomimetic imitation of the native cellular microenvironment given by the properties of the native extracellular matrix (ECM).
In this last point the use of different components on the native ECM such as peptides, (structural) proteins, growth factors, glycosaminoglycanes as well as nucleic acids and aptamers for BioSurface Engineering discussed. This will include immobilization strategies in their advantages and disadvantages for different substrates and components. If possible this will be combined with examples from current research topics of our group.
Finally within the course possibilities of physically influencing cellular behavior up to healing process by mechanical stimulation, electric and magnetic fields will be discussed.
Key aspects in this area will be the relevance of the signals for cells, signal transmission and recognition by cells and the role of the type of signals.
The course can be given alternatively in German or English and is designed especially for graduate students in materials science, biotechnology and science.
The course takes place on Friday in the 5th double hour (i.e. starting 14:50 h) in the seminar room in the ground floor of the Max Bergmann Center of Biomaterials, Budapester Str. 27.