PMID- 15173891
OWN - NLM
STAT- MEDLINE
DA  - 20040602
DCOM- 20040629
LR  - 20041117
PUBM- Print
IS  - 0021-9738
VI  - 113
IP  - 11
DP  - 2004 Jun
TI  - Receptor for advanced glycation end products (RAGE) regulates sepsis but
      not the adaptive immune response.
PG  - 1641-50
AB  - While the initiation of the adaptive and innate immune response is well
      understood, less is known about cellular mechanisms propagating
      inflammation. The receptor for advanced glycation end products (RAGE), a
      transmembrane receptor of the immunoglobulin superfamily, leads to
      perpetuated cell activation. Using novel animal models with defective or
      tissue-specific RAGE expression, we show that in these animal models RAGE
      does not play a role in the adaptive immune response. However, deletion of
      RAGE provides protection from the lethal effects of septic shock caused by
      cecal ligation and puncture. Such protection is reversed by reconstitution
      of RAGE in endothelial and hematopoietic cells. These results indicate
      that the innate immune response is controlled by pattern-recognition
      receptors not only at the initiating steps but also at the phase of
      perpetuation.
AD  - Department of Molecular Immunology, Division of Tumor Immunology, German
      Cancer Research Center, Heidelberg, Germany.
FAU - Liliensiek, Birgit
AU  - Liliensiek B
FAU - Weigand, Markus A
AU  - Weigand MA
FAU - Bierhaus, Angelika
AU  - Bierhaus A
FAU - Nicklas, Werner
AU  - Nicklas W
FAU - Kasper, Michael
AU  - Kasper M
FAU - Hofer, Stefan
AU  - Hofer S
FAU - Plachky, Jens
AU  - Plachky J
FAU - Grone, Herman-Josef
AU  - Grone HJ
FAU - Kurschus, Florian C
AU  - Kurschus FC
FAU - Schmidt, Ann Marie
AU  - Schmidt AM
FAU - Yan, Shi Du
AU  - Yan SD
FAU - Martin, Eike
AU  - Martin E
FAU - Schleicher, Erwin
AU  - Schleicher E
FAU - Stern, David M
AU  - Stern DM
FAU - Hammerling G, G unterJ
AU  - Hammerling G G
FAU - Nawroth, Peter P
AU  - Nawroth PP
FAU - Arnold, Bernd
AU  - Arnold B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Invest
JID - 7802877
RN  - 0 (Receptors, Immunologic)
RN  - 0 (advanced glycosylation end-product receptor)
SB  - AIM
SB  - IM
MH  - Animals
MH  - Cecum/injuries
MH  - Immune System/immunology/*metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Peritonitis/metabolism
MH  - Receptors, Immunologic/genetics/immunology/*metabolism
MH  - Research Support, Non-U.S. Gov't
MH  - Sepsis/*metabolism
MH  - Shock, Septic/metabolism
MH  - Time Factors
EDAT- 2004/06/03 05:00
MHDA- 2004/06/30 05:00
PHST- 2003/04/18 [received]
PHST- 2004/03/26 [accepted]
AID - 10.1172/JCI200418704 [doi]
PST - ppublish
SO  - J Clin Invest 2004 Jun;113(11):1641-50.