12.12.2018; Kolloquium

ZIH-Kolloquium- The invasion speed of cell migration models with realistic cell cycle time distributions

Zentrum für Informationsdienste und Hochleistungsrechnen (ZIH)
11:30 - 12:30 Uhr
APB 1096
APB Andreas-Pfitzmann-Bau
Nöthnitzer Str. 46
01187 Dresden

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Enrico Gavagnin (University of Bath)
Müller-Pfefferkorn © ZIH
Name

Dr. Ralph Müller-Pfefferkorn

Abteilungsleiter VDR

Organisationsname

Zentrum für Informationsdienste und Hochleistungsrechnen (ZIH)

Zentrum für Informationsdienste und Hochleistungsrechnen (ZIH)

Adresse work

Besucheradresse:

Falkenbrunnen, Raum 240 Chemnitzer Str. 46b

01187 Dresden

Kolloquium © ZIH Kolloquium © ZIH
Kolloquium

© ZIH

„The invasion speed of cell migration models with realistic cell cycle time distributions“
Cell proliferation is typically incorporated into stochastic mathematical models of cell migration by assuming that cell divisions occur after an exponentially distributed waiting time. Experimental observations, however, show that this assumption is often far from the real cell cycle time distribution (CCTD). In this talk I will  investigate the connection between the CCTD and the speed of the collective cell invasion. I will present a series of stochastic and deterministic age-structured models which can be used to explore this connection from an analytical perspective. The results allow us to determine the range of possible invasion speeds in terms of the average cell proliferation time. Finally, I will discuss potential medical applications of these models to melanoma drug treatment optimisation and other extensions.

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Ralph Müller-Pfefferkorn
Letzte Änderung: 04.12.2018