Halogenation of phenylethane glycosides from Verbascum
Verbascum species have a variety of bioactive compounds, including high value iridoid and phenylethanoid glycosides, hence the development of alternative approaches for their sustainable supply is highly relevant. Hairy Root cultures can partially contribute to this problem. Halogenation can sometimes increase the bioactivity, bioavailability or alter the activity completely. Thus, the aim of the project was to transform Verbascum species with bacterial halogenases by means of Agrobacterium rhizogenesto establish wild type and halogenase-transformed stable Hairy Root cultures. With these cultures metabolite analyis and bioactivity tests should be performed to evaluate whether 1) halogenated compounds are present and 2) whether these might have other bioactive properties.
Publication:
- Georgiev, M.I., A., Neumann, M., Marchev, A., Alipieva, K., Ludwig-Müller, J. (2015) Metabolomic differentiations of Verbascum nigrum L. plants and SAArT transformed hairy roots. Plant Cell Tiss. Org. Cult. 123: 349-356
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