Complete list of publications

2025

  • Peiter, N., Einert, A., Just, P, Jannasch, F., Najdovska, M. and Rother, M. (2025) Defining the methanogenic SECIS Element in vivo by targeted mutagenesis. RNA Biol. 22: 1-13, doi: 10.1080/15476286.2025.2472448.
  • Mentrup, A., Scheitz, L.V., Wallenfang, T. and Rother, M. (2025) Production of the sesquiterpene bisabolene from one- and two carbon compounds in an engineered Methanosarcina acetivorans. Microb. Biotechnol. 18: e70105, doi: 10.1111/1751-7915.70105.
  • Bao, J., Somvanshi, T., Tian, Y., Laird, M., Garcia, P., Schöne, C., Rother, M., Borrel, G. and Scheller, S. (2025) Nature AND Nurture: Enabling formate-dependent growth in Methanosarcina acetivorans. FEBS J., doi: 10.1111/febs.17409.

2024

  • Chadwick, G.L., Nayak, D.D., Rother, M. and Metcalf, W.W. (2024) No evidence for methanotrophic growth of diverse marine methanogens. Proc. Natl. Acad. Sci. USA, 121: e2404143121; doi: 10.1073/pnas.2404143121.
  • Funkner, K., Poehlein, A., Jehmlich, N., Egelkamp, R ., Daniel, R., von Bergen, M. and Rother, M. (2024) Proteomic and transcriptomic analysis of selenium utilization in Methanococcus maripaludis. mSystems 9: e01338-23, doi: 10.1128/msystems.01338-23.
  • Rother, M. (2024) Wie Mikroben den Klimawandel bekämpfen können. BIOspektrum, Springer-Verlag, Vol. 30 (01.24), pp. 124, doi: 10.1007/s12268-024-2081-5.
  • Richter, M., Sattler, C., Schöne, C. and Rother, M. (2024) Pyruvate-dependent growth of Methanosarcina acetivorans. J. Bacteriol. 206: e00363-23, doi: 10.1128/jb.00363-23.

2023

  • The Role of Microbes in Mediating Methane Emissions: Report on an American Academy of Microbiology Colloquium held on May 31 and June 1, 2023. Washington (D.C.): American Society for Microbiology; 2023. Report, Press release.

  • Schöne, C., Poehlein, A. and Rother, M. (2023) Genetic and physiological probing of cytoplasmic bypasses for the energy-converting methyltransferase Mtr in Methanosarcina acetivorans. Appl. Environ. Microbiol. 89: e02161-22, doi: 10.1128/aem.02161-22.

2022

  • Peiter, N. and Rother, M. (2022) In vivo probing of SECIS-dependent selenocysteine translation in Archaea. Life Sci. Alliance 6: e202201676, doi: 10.26508/lsa.202201676.

  • Contreras, G., Thomsen, J., Pfitzer, M., Hafenbradl, D., Kostner, D., Holtmann, D., Schmitz, R.A., Rother, M. and Molitor, B. (2022) New perspectives for biotechnological applications with methanogens. Curr. Res. Biotechnol. 4: 468-474, doi: 10.1016/j.crbiot.2022.10.001.

  • Schöne, C., Poehlein, A., Jehmlich, N., Adlung, N., Daniel, R., von Bergen, M., Scheller, S. and Rother, M. (2022) Deconstructing Methanosarcina acetivorans into an acetogenic archaeon. Proc. Natl. Acad. Sci. USA 119: e2113853119, doi: 10.1073/pnas.2113853119Press release Commentary in Biospektrum (in German)

2021

  • Weidenbach, K., Wolf, S., Kupczok, A., Kern, T., Fischer, M.A., Reetz, J., Urbanska, N., Schmitz, R.A. and Rother, M. (2021) Characterization of Blf4, an archaeal lytic virus targeting a member of the Methanomicrobiales. Viruses 13: 1934, doi: 10.3390/v13101934.

2020

  • Rother, M.,  Whitman, W.B., Boone, D.R. and Koga, Y. (2020) Methanococcaceae. In Bergey’s Manual of Systematics of Archaea and Bacteria. Whitman, W.B. (ed). John Wiley & Sons, Inc., in association with Bergey's Manual Trust (online), doi: 10.1002/9781118960608.fbm00100.pub2.

2019

  • Rother, M. and Whitman, W.B. (2019) Methanococcus. In Bergey’s Manual of Systematics of Archaea and Bacteria. Whitman, W.B. (ed). John Wiley & Sons, Inc., in association with Bergey's Manual Trust (online), doi: 10.1002/9781118960608 .gbm00502.pub2.
  • Rother, M. and Whitman, W.B. (2019) Methanothermococcus. In Bergey’s Manual of Systematics of Archaea and Bacteria. Whitman, W.B. (ed). John Wiley & Sons, Inc., in association with Bergey's Manual Trust (online), doi: 10.1002/978111896060 8.gbm00503.pub2.
  • Wolf, S., Fischer, M.A., Kupczok, A., Reetz, J., Kern, T., Schmitz, R.A. and Rother, M. (2019) Characterization of the lytic archaeal virus Drs3 infecting Methanobacterium formicicum. Arch. Virol., 164:667–674, doi: 10.1007/s00705-018-04120-w.

2018

  • Deobald, D., Adrian, L., Schöne, C., Rother, M. and Layer, G. (2018) Identification of a unique Radical SAM methyltransferase required for the sp3-C-methylation of an arginine residue of methyl-coenzyme M reductase. Sci. Rep. 8:7404, doi: 10.1038/s41598-018-25716-x.
  • Poehlein, A., Heym, D., Quitzke, V., Fersch, J., Daniel, R. and Rother, M. (2018) Complete genome sequence of the Methanococcus maripaludis type strain JJ (DSM 2067), a model for selenoprotein synthesis in Archaea. Genome Announc. 6:e00237-18, doi: 10.1128/genomeA.00237-18.
  • Quitzke, V., Fersch, J., Seyhan, D. and Rother, M. (2018) Selenium-dependent gene expression in Methanococcus maripaludis: Involvement of the LysR-type transcriptional regulator HrsM. Biochim. Biophys. Acta, 1862: 2441-2450, doi: 10.1016/j.bbagen.2018.03.030.
  • Rother, M. and Quitzke, V. (2018) Selenoprotein synthesis and regulation in Archaea. Biochim. Biophys. Acta, 1862: 2451-2462 doi: 10.1016/j.bbagen.2018.04.008.
  • Enzmann, F., Mayer, F., Rother, M. and Holtmann, D.  (2018) Methanogens – biochemical background and biotechnological applications. AMB Express  8:1, doi: 10.1186/s13568-017-0531-x.
  • Rother, M. and Schöne, C. (2018) Methanogenesis from carbon monoxide. In Handbook of Hydrocarbon and Lipid Microbiology. 2nd edition. Timmis, K.N. (ed). Springer-Verlag, Berlin/Heidelberg, Germany, published online, doi: 10.1007/978-3-319-53114-4_4-1.

2016

  • Rother, M. (2016) Prokaryotic selenoprotein biosynthesis and function. In Selenium: its molecular biology and role in human health. 4th ed. Hatfield, D.L., Schweizer, U., Tsuji, A.P. and P.A. Gladyshev, V.N. (eds.), Springer International Publishing, Cham, Switzerland, pp. 47-58, doi: 10.1007/978-3-319-41283-2_5.
  • Fujishiro, T., Bai, L., Xu, T., Xie, X., Schick, M., Kahnt, J., Rother, M., Hu, X., Ermler, U. and Shima, S. (2016) Identification of HcgC as a SAM-dependent pyridinol methyltransferase in [Fe]-hydrogenase cofactor biosynthesis. Angew. Chem. Int. Ed. Engl. 55:9648-9651, doi: 10.1002/anie.201604352.
  • Theiss, J., Rother, M. and Röske, K. (2016) Influence of DNA isolation method on the investigation of archaeal diversity and abundance in biogas plants. Arch. Microbiol. 198:619-628, doi: 10.1007/s00203-016-1221-9.
  • Kern, T., Theiss, J., Röske, K. and Rother, M. (2016) Assessment of hydrogen metabolism in commercial anaerobic digesters. Appl. Microbiol. Biotechnol. 100:4699-710,  doi: 10.1007/s00253-016-7436-5.

  • Kern, T., Fischer, M.A., Deppenmeier, U., Schmitz, R.A. and Rother, M. (2016) Methanosarcina flavescens sp. nov., a methanogenic archaeon isolated from a full-scale anaerobic digester. Int. J. Syst. Evol. Microbiol. 66:1533-1538, doi: 10.1099/ijsem.0.000894.

2015

  • Seyhan, D., Jehmlich, N., von Bergen, M., Fersch, J. and Rother, M. (2015) Selenocysteine-independent suppression of UGA codons in the archaeon Methanococcus maripaludis. Biochim. Biophys. Acta. 1850:2385-2392, doi: 10.1016/j.bbagen.2015.07.009.
  • Kern, T., Linge, M. and Rother, M. (2015) Methanobacterium aggregans sp. nov., a hydrogenotrophic methanogenic archaeon isolated from an anaerobic digester. Int. J. Syst. Evol. Microbiol. 65:1975-980, doi: 10.1099/ijs.0.000210.
  • Rother, M. (2015) Selenocysteine. In Encyclopedia of Life Science (www.els.net). Agrò A. F. (ed.), Wiley, Chichester, UK., doi:10.1002/9780470015902.a0000688.pub3.
  • Matschiavelli, N. and Rother, M. (2015) Role of a putative tungsten-dependent formyl-methanofuran dehydrogenase in Methanosarcina acetivorans. Arch. Microbiol. 197:379-388, doi: 10.1007/s00203-014-1070-3.

2014

  • Demolli, S., Geist, M.M., Matschiavelli, N. Weigand, J.E., Suess, B. and Rother, M. (2014) Development of β-lactamase as a tool for monitoring conditional gene expression by a tetracycline-riboswitch in Methanosarcina acetivorans. Archaea 2014:725610, doi: 10.1155/2014/725610.

2013

  • Rother, M. (2013) Selenoproteins in Prokaryotes. In Enzyclopedia of Metalloproteins. Kretsinger, R. H., Permyakov, E. A., Uversky, V. N. (eds.), Springer, New York, pp. 1959-1964, doi: 10.1007/978-1-4614-1533-6_466.
  • Sattler, C., Wolf, S., Fersch, J., Goetz, S. and Rother, M. (2013) Random mutagenesis identifies factors involved in formate-dependent growth of the methanogenic archaeon Methanococcus maripaludis. Mol. Genet. Genomics 288:413-424, doi: 10.1007/s00438-013-0756-6.
  • Molitor, B., Stassen, M., Modi, A., El-Mashtoly, S., Laurich, C., Lubitz, C., Dawson, J.H., Rother, M. and Frankenberg-Dinkel, N. (2013) A heme-based redox sensor in the methanogenic archaeon Methanosarcina acetivorans. J. Biol. Chem. 288:18458-18472, doi: 10.1074/jbc.M113.476267.

2012

  • Matschiavelli, N., Oelgeschläger, E., Cocchiararo, B., Finke, J. and Rother, M. (2012) Function and regulation of isoforms of carbon monoxide dehydrogenase/ acetyl-CoA synthase in Methanosarcina acetivorans. J. Bacteriol. 194:5377-5387, doi: 10.1128/JB.00881-12.
  • Rother, M. (2012) Selenium metabolism in prokaryotes. In Selenium: its molecular biology and role in human health. 3rd ed. Hatfield, D.L., Berry, M.J. and Gladyshev, V.N. (eds.), Springer-Verlag, New York, pp. 457-470.
  • Kliefoth, M., Langer, J.D., Matschiavelli, N., Oelgeschläger, E. and Rother, M. (2012) Genetic analysis of MA4079, an aldehyde dehydrogenase homolog, in Methanosarcina acetivorans. Arch. Microbiol. 194:75-85, doi: 10.1007/s00203-011-0727-4.

2011

  • Stock, T., Selzer, M. Connery, S., Seyhan, D., Resch, A. and Rother, M. (2011) Disruption and complementation of the selenocysteine biosynthesis pathway reveals a hierarchy of selenoprotein gene expression in the archaeon Methanococcus maripaludis. Mol. Microbiol. 82:734–747, doi: 10.1111/j.1365-2958.2011.07850.x.
  • Rother, M., Sattler, C. and Stock, T. (2011) Studying gene regulation in methanogenic archaea. In Methods in Methane Metabolism. Rosenzweig, A. and Ragsdale S.W. (eds.) Meth. Enzymol. 494:91-110, doi: 10.1016/B978-0-12-385112-3.00005-6.
  • Hildenbrand, C., Stock, T., Lange C., Rother, M. and Soppa, J. (2011) Genome copy numbers and gene conversion in methanogenic archaea. J. Bacteriol. 193:734-743, doi: 10.1128/JB.01016-10.

2010

  • Rother, M. and Krzycki, J.A. (2010) Selenocysteine, pyrrolysine and the unique energy metabolism of methanogenic archaea. Archaea 2010:453642, doi: 10.1155/2010/453642.
  • Rother, M. (2010) Methanogenesis. In Handbook of Hydrocarbon and Lipid Microbiology. Vol.1, Part 6. Timmis, K.N. (ed). Springer, Berlin/Heidelberg, pp. 483-499, doi: 10.1007/978-3-540-77587-4_36.
  • Stock, T., Selzer, M. and Rother, M. (2010) In vivo requirement of selenophosphate for selenoprotein synthesis in archaea. Mol. Microbiol. 75:149-160, doi: 10.1111/j.1365-2958.2009.06970.x.

2009

  • Stock, T. and Rother, M. (2009) Selenoproteins in Archaea and Gram-positive Bacteria. Biochim. Biophys. Acta 1790:1520-1532, doi: 10.1016/j.bbagen.2009.03.022.
  • Oelgeschläger, E. and Rother, M. (2009) In vivo role of three fused corrinoid/methyl-transfer proteins in Methanosarcina acetivorans. Mol. Microbiol. 72:1260-1272, doi: 10.1111/j.1365-2958.2009.06723.x.
  • Oelgeschläger, E. and Rother, M. (2009) Influence of carbon monoxide on metabolite formation in Methanosarcina acetivorans. FEMS Microbiol. Lett. 292:254-260, doi: 10.1111/j.1574-6968.2009.01492.x.

2008

  • Guss, A., Rother, M., Zhang, J.K., and Metcalf, W.W. (2008) New methods for tightly regulated gene expression and highly efficient chromosomal integration of cloned genes for Methanosarcina species. Archaea 2:193-203, doi: 10.1155/2008/534081.
  • Oelgeschläger, E. and Rother, M. (2008) Carbon monoxide-dependent energy metabolism in anaerobic bacteria and archaea. Arch. Microbiol. 190:257-269, doi: 10.1007/s00203-008-0382-6.

2007

  • Rother, M., Oelgeschläger, E. and Metcalf, W.W. (2007) Genetic and proteomic analyses of CO utilization by Methanosarcina acetivorans. Arch. Microbiol. 188:463-472, doi: 10.1007/s00203-007-0266-1.

2006

  • Bose, A., Pritchett, M.A., Rother, M. and Metcalf, W.W.(2006) Differential regulation of the three methanol methyltransferase isozymes in Methanosarcina acetivorans C2A. J. Bacteriol. 188:7274-7283, doi: 10.1128/JB.00535-06.
  • Böck, A., Rother, M., Leibundgut, M. and Ban, N. (2006) Selenium metabolism in prokaryotes. In Selenium: its molecular biology and role in human health. 2nd ed. Hatfield, D.L., Berry, M.J. and Gladyshev, V.N. (eds.), Springer-Verlag, New York, pp. 9-28, doi: 10.1007/0-387-33827-6_2.
  • Patrie, S.M., Ferguson, J.T., Robinson, D.E., Whipple, D., Rother, M., Metcalf, W.W. and Kelleher, N.L. (2006) Top down mass spectrometry of <60 kDa proteins from Methanosarcina acetivorans using Q-FTMS with automated octopole collisionally activated dissociation (OCAD). Mol. Cell Proteomics 5:14-25, doi: 10.1074/mcp.M500219-MCP200.

2005

  • Kaiser, J.T., Gromadski, K., Rother, M., Engelhardt, H., Rodnina, M.V. and Wahl, M.C. (2005) Structural and functional investigation of a putative archaeal selenocysteine synthase. Biochemistry 44:13315-13327, doi: 10.1021/bi051110r.
  • Böck, A., Thanbichler, M., Rother, M. and Resch, A. (2005) Selenocysteine. In Aminoacyl-tRNA Synthetases. Ibba, M., Francklyn, C.S. and Cusack, S. (eds.), Landes Bioscience, Georgetown, USA, pp. 320-327.
  • Rother, M., Boccazzi, P., Bohse. A., Pritchett, M.A. and Metcalf, W.W. (2005) Methanol-dependent gene expression demonstrates that methyl-CoM reductase is essential in Methanosarcina acetivorans C2A and allows isolation of mutants with defects in regulation of the methanol utilization pathway. J. Bacteriol. 187:5552-5559, doi: 10.1128/JB.187.16.5552-5559.2005.
  • Rother, M. and Metcalf, W.W. (2005) Genetic technologies for Archaea. Curr. Opin. Microbiol. 8:745-751, doi: 10.1016/j.mib.2005.10.010.
  • Böck, A. and Rother, M. (2005) A pseudo-SECIS element in Methanococcus voltae documents evolution of a selenoprotein into a sulphur-containing homologue. Arch. Microbiol. 183:148-150, doi: 10.1007/s00203-004-0744-7.

2004

  • Rother, M. and Metcalf, W.W. (2004) Anaerobic growth of Methanosarcina acetivorans C2A on carbon monoxide: an unusual way of life for a methanogenic archaeon. Proc. Natl. Acad. Sci. USA 101:16929-16934, doi: 10.1073/pnas.0407486101.
  • Peters, F., Rother, M. and Boll, M. (2004) Selenocysteine-containing proteins in anaerobic benzoate metabolism of Desulfococcus multivorans. J. Bacteriol. 186:2156-2163, doi: 10.1128/JB.186.7.2156-2163.2004.

2003

  • Rother, M., Mathes, I., Lottspeich, F., and Böck, A. (2003) Inactivation of the selB gene in Methanococcus maripaludis: Effect on the synthesis of selenoproteins and their sulfur containing homologs. J. Bacteriol. 185:107-114, doi: 10.1128/JB.185.1.107-114.2003.

2002

  • Herkel, J., Heidrich, B., Nieraad, N., Wies, I., Rother, M. and Lohse, A.W. (2002) Fine specificity of autoantibodies to soluble liver antigen and liver/pancreas. Hepatology 35:403-408, doi: 10.1053/jhep.2002.30699.

2001

  • Rother, M., Böck, A. and Wyss, C. (2001) Selenium dependent growth of Treponema denticola: evidence for a clostridial-type glycine reductase. Arch. Microbiol. 177:113-116, doi: 10.1007/s002030100351.
  • Rother, M., Resch, A., Wilting, R. and Böck, A. (2001) Selenoprotein synthesis in archaea. BioFactors 14:75-83, doi: 10.1002/biof.5520140111.
  • Rother, M., Resch, A., Gardner, W.L., Whitman, W.B. and Böck, A. (2001) Heterologous expression of archaeal selenoprotein genes directed by the SECIS element located in the 3' non-translated region. Mol. Microbiol. 40:900-908, doi: 10.1046/j.1365-2958.2001.02433.x.

2000

  • Rother, M., Wilting, R., Commans, S. and Böck, A. (2000) Identification and characterisation of the selenocysteine-specific translation factor SelB from the archaeon Methanococcus jannaschii. J. Mol. Biol. 299:351-358, doi: 10.1006/jmbi.2000.3756.

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AG Rother
Last modified: Jul 04, 2025