Prof. Dr. med. Markus Loeffler
Research focus
- Biometry of interventional clinical trials and cohort studies
- Epidemiology of civilization diseases
- Bioinformatics of multi-omics data, high-dimensional data analysis
- Dynamic modeling of tissue organization
- Medical informatics on data accessibility of EMR
Table of contents
Curriculum Vitae
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Loeffler, Markus, Prof. Dr. med. |
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Official position |
Full Professor and Director of the Institute of Medical Informatics, Statistics and Epidemiology Leipzig |
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Institution |
Institute of Medical Informatics, Statistics and Epidemiology Leipzig |
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Business address |
Härtelstr. 16-18, 04107 Leipzig, Germany |
Academic education and degrees
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1974-1980 |
Study of Medicine at University of Köln |
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1974-1982 |
Study of Physics at University of Köln |
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1980 |
Approbation to practise medicine |
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1982 |
Diploma in Physics |
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1983 |
Dissertation (Dr. med.), University Köln |
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1990 |
Habilitation and Venia Legendi in Medical Documentation, Statistics and Biomathematics, University Köln |
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1993 |
Sabbatical Leave, Dept. Statistics, University Reading, England |
Professional career
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1980-1984 |
Research assistant Biometry, University Köln |
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1984-1994 |
Research group leader Biometry, University Köln |
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Since 1994 |
Full Professor and Director of the Institute of Medical Informatics, Statistics and Epidemiology Leipzig (IMISE) |
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Since 1999 |
Scientific Director of the Center of Clinical Trials Leipzig (ZKS) |
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Since 2001 |
Scientific Director of the Interdisciplinary Center for Bioinformatics (IZBI) |
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Since 2009 |
Scientific Director of the LIFE Research Center for Civilization Diseases |
Honors, awards and positions
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Member of the Program Commission of the System Medicine Consortia (e:MED) |
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Member of the National Steering Committee of the Medical Informatics Initiative (MI-I) |
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Board of Directors of the German National Cohort (GNC) |
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Since 2018 |
PI of The SMITH Consortium of the Medical Informatics Initiative |
10 most important peer-reviewed papers
(10 out of 394 publications, SCOPUS h-index: 87)
Winter A, Stäubert S, Ammon D, … Loeffler M. Smart Medical Information Technology for Healthcare (SMITH). Methods Inf Med. 2018;57(S 01):e92-e105.
Loeffler M, Engel C, Ahnert P, Alfermann D, Arelin K et al. The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany. BMC Public Health. 2015;15:691.
Spada J, Scholz M, Kirsten H, … Loeffler M et al. Genome-wide association analysis of actigraphic sleep phenotypes in the LIFE Adult Study. J Sleep Res. 2016;25(6):690-701.
Kharabian Masouleh S, Beyer F, Lampe L, Loeffler M et al. Gray matter structural networks are associated with cardiovascular risk factors in healthy older adults. J Cereb Blood Flow Metab. 2018;38(2):360-372.
Vojinovic D, Adams HH, Jian X, … Loeffler M et al. Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nat Commun. 2018;9(1):3945.
Satizabal CL, Adams HHH, Hibar DP, … Loeffler M et al. Genetic architecture of subcortical brain structures in 38,851 individuals. Nat Genet. 2019;51(11):1624-1636.
Yahiaoui-Doktor M, Luck T, Riedel-Heller SG, Loeffler M, Wirkner K, Engel C. Olfactory function is associated with cognitive performance: results from the population-based LIFE-Adult-Study. Alzheimers Res Ther. 2019;11(1):43.
Bloos F, Trips E, Nierhaus A, … Loeffler M, Reinhart K; for SepNet Critical Care Trials Group. Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial. JAMA Intern Med. 2016;176(9):1266-76.
Chapuy B, Stewart C, Dunford AJ, … Loeffler M, et al. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018;24(5):679-690.