Important Reviews & Selected Publications
Important Reviews
2022
Becker, T., and Becker, C.G. (2022). Regenerative neurogenesis: the integration of developmental, physiological and immune signals.
Development 149 doi: 10.1242/dev.199907
Wehner, D., and Becker, C.G. (2022). An exception to the rule? Regeneration of the injured spinal cord in the spiny mouse.
Dev Cell 57, 415-416
2020
Coaxing stem cells to repair the spinal cord.
Becker CG, Becker T
Science. DOI: 10.1126/science.abe1661
Neural circuit reorganisation after spinal cord injury in Zebrafish
El-Daher F, Becker CG
Current Opinions in Genetics DOI: 10.1016/j.gde.2020.05.017
Dynamic cell interactions allow spinal cord regeneration in zebrafish
Becker T, Becker CG
Current Opinions in Physiology 14:64–69 DOI: 10.1016/j.cophys.2020.01.009
2018
The spinal ependymal zone as a source of endogenous repair cells across vertebrates
Becker CG, Becker T, Hugnot JP
Progress in Neurobiology, in press DOI: 10.1016/j.pneurobio.2018.04.002
2017
Reduce, Reuse, Recycle - Developmental Signals in Spinal Cord Regeneration.
Cardozo MJ, Mysiak KS, Becker T, Becker CG
Developmental Biology, DOI:10.1016/j.ydbio.2017.05.011
2015
Neuronal regeneration from ependymo-radial glial cells: cook, little pot, cook!
Becker CG, Becker T
Developmental Cell 32 (4), 516-527, DOI: 10.1016/j.devcel.2015.01.001
2014
Axonal regeneration in zebrafish
Becker T, Becker CG
Current Opinion in Neurobiology 27, 186-191 DOI: 10.1016/j.conb.2014.03.019
Publications
2022
Targeting phosphoglycerate kinase 1 with terazosin improves motor neuron phenotypes in multiple models of amyotrophic lateral sclerosis.
Chaytow, H., Carroll, E., Gordon, D., Huang, Y.T., van der Hoorn, D., Smith, H.L., Becker, T., Becker, C.G., Faller, K.M.E., Talbot, K., et al.
EBioMedicine 83, 104202
Truly-Biocompatible Gold Catalysis Enables Vivo-Orthogonal Intra-CNS Release of Anxiolytics.
Ortega-Liebana, M.C., Porter, N.J., Adam, C., Valero, T., Hamilton, L., Sieger, D., Becker, C.G., and Unciti-Broceta, A.
Angew Chem Int Ed Engl 61, e202111461
2021
A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord.
Cavone, L., McCann, T., Drake, L.K., Aguzzi, E.A., Oprişoreanu, A.M., Pedersen, E., Sandi, S., Selvarajah, J., Tsarouchas, T.M., Wehner, D., et al.
Dev Cell 56, 1617-1630.e1616
Controlled Semi-Automated Lased-Induced Injuries for Studying Spinal Cord Regeneration in Zebrafish Larvae.
El-Daher, F., Early, J.J., Richmond, C.E., Jamieson, R., Becker, T., and Becker, C.G.
J Vis Exp. doi: 10.3791/63259
CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury.
Keatinge, M., Tsarouchas, T.M., Munir, T., Porter, N.J., Larraz, J., Gianni, D., Tsai, H.H., Becker, C.G., Lyons, D.A., and Becker, T.
PLoS Genet 17, e1009515
Automated in vivo drug screening for synapse-stabilisation in zebrafish.
Oprişoreanu, A.-M., Smith, H.L., Krix, S., Chaytow, H., Carragher, N., Gillingwater, T.H., Becker, C.G., and Becker, T.
Dis Model Mech doi:10.1242/dmm.047761
2019
Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation.
Oprisoreanu, A.M., Smith, H.L., Arya, S., Webster, R., Zhong, Z., Wehner, D., Cardozo, M.J., Becker, T., Talbot, K., and Becker, C.G.
Cell Rep 29, 1082-1098.e1010
Regeneration of dopaminergic neurons in adult zebrafish depends on immune system activation and differs for distinct populations
Caldwell LJ, Davies NO, Cavone L, Mysiak KS, Semenov SA, Panula P, Armstrong JD, Becker CG, Becker T
Neurosci 12;39(24):4694-4713
2018
Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages is necessary for functional spinal cord regeneration in zebrafish
Tsarouchas TM, Wehner D, Cavone L, Munir T, Keatinge M, Lambertus M, Underhill A, Barrett T, Kassapis E, Ogryzko N, Feng Y, van Ham TJ, Becker T, Becker CG
Nature Communication 7;9(1):4670 DOI: 10.1038/s41467-018-07036-w
Wnt signaling controls a pro-regenerative extracellular matrix in functional spinal cord regeneration
Wehner D, Tsarouchas TM, Michael A, Haase C, Weidinger G, Reimer MM, Becker T, Becker CG
Nature Communications 25;8(1):126 DOI: 10.1038/s41467-017-00143-0
2017
Bioenergetic status determines motor neuron vulnerability in spinal muscular atrophy Boyd PJ, Tu WY, Shorrock HK, Powis RA, Groen EJN, Thomson SR, Thomson D, Graham LC, Wishart TM, Highley JR, Becker T, Becker CG, Heath PR, Gillingwater TH
PLoS Genetics 13(4):e1006744
2016
Spinal Motor Neurons are Regenerated after Mechanical Lesion and Genetic Ablation in Larval Zebrafish.
Ohnmacht J, Yang Y, Maurer GW, Barreiro-Iglesias A, Tsarouchas TM, Wehner D, Sieger D, Becker CG, Becker T
Development 143:1464-1474
2015
Serotonin Promotes Development and Regeneration of Spinal Motor Neurons in Zebrafish.
Barreiro-Iglesias A, Mysiak KS, Scott AL, Reimer MM, Yang YJ, Becker CG, Becker T
Cell Reports 13(5):924-32
2014
Dysregulation of Ubiquitin Homeostasis and β-catenin Signalling Promote Spinal Muscular Atrophy.
Wishard TM, Mutsaers CA, Riesland M, Reimer MM, Fuller HR, Hannam ML, Morse R, Young PJ, Lamont DJ, Hammerschmidt M, Morris GE, Parson SH, Skehel PA, Becker T, Robinson IM, Becker CG, Wirth B, Gillingwater TH
Journal of Clinical Investigation 124(4):1821-34
2013
Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy.
Sleigh JN, Barreiro-Iglesias A, Oliver PL, Biba A, Becker T, Davies KE, Becker CG, Talbot K.
Hum Mol Genet 23(4):855-69
Dopamine signaling from the brain augments spinal motor neuron generation during development and adult regeneration via hedgehog pathway activation.
Reimer MM, Norris A, Ohnmacht J, Patani R, Zhong Z, Dias TB, Kuscha V, Scott AL, Chen Y, Rozov S, Frazer SL, Wyatt C, Higashijima S, Patton EE, Panula P, Chandran S, Becker T, Becker CG
Dev Cell 25(5): 478-491
2012
Chondrolectin mediates growth cone interactions of motor axons with an intermediate target.
Zhong Z, Ohnmacht J, Reimer MM, Bach I, Becker T, Becker CG
J Neurosci 32(13):4426-39
Notch signalling controls generation of motor neurons in the lesioned spinal cord of adult zebrafish.
Dias TB, Yang YJ, Ogai K, Molist P, Becker T, Becker CG
J Neurosci 32(9):3245-52