Publikationen

key publictations

Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo
Sethuraman Subramanian , Clara Jana-Lui Busch, Kaaweh Molawi, Laufey Geirsdottir, Julien Maurizio, Stephanie Vargas Aguilar, Hassiba Belahbib, Gregory Gimenez, Ridzky Anis Advent Yuda, Michaela Burkon, Jérémy Favret, Sara Gholamhosseinian Najjar, Bérengère de Laval, Prashanth Kumar Kandalla, Sandrine Sarrazin, Lena Alexopoulou , Michael H. Sieweke 
Nature Immunology volume 23, pages458–468 (2022)

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C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells
de Laval B., Maurizio J., Kandalla P K., Brisou G., Simonnet L., Huber C., Gimenez G., Matcovitch-Natan O., Reinhardt S., David E., Mildner A., Leutz A., Nadel B., Bordi C., Amit I., Sarrazin S., Sieweke M H.
Cell Stem Cell, 2020 , pii: S1934-5909(20)30017-5, PMID: 32169166

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Microglia development follows a stepwise program to regulate brain homeostasis
Matcovitch-Natan O, Winter DR, Giladi A, Vargas Aguilar S, Spinrad A, Sarrazin S, Ben-Yehuda H, David E, Zelada Gonzalez F, Perrin P, Keren-Shaul H, Gury M, Lara-Astaiso D, Thaiss CA, Cohen M, Halpern KB, Baruch K, Deczkowska A, Lorenzo-Vivas E, Itzkovitz S, Elinav E, Sieweke MH*, Schwartz M*, Amit I*
Science 353, aad8670. (2016) [* equal contribution]

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells
Soucie EL, Wenig W, Geirsdóttir L, Molawi K, Maurizio J, Fenouil R, Mossadegh-Keller N, Gimenez G, VanHille L, Beniazza M, Favret J, Berruyer C, Perrin P, Hacohen N, Andrau JC, Ferrier P, Dubreuil P, Sidow A, Sieweke
Science 351, aad5510 (2016)

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells
Mossadegh-Keller N, Sarrazin S, Kandalla PK, Espinosa L, Stanley RE, Nutt SL, Moore J, Sieweke
Nature 9, 239–243 (2013)

MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages
Aziz A, Soucie E, Sarrazin S, Sieweke
Science 326, 867–871 (2009)

MafB restricts M-CSF dependent myeloid commitment divisions of hematopoietic stem cells
Sarrazin S, Mossadegh-Keller N, Fukao T, Aziz A, Mourcin F., Kelly L, Vanhille L, Kastner P, Chan S, Duprez E, Otto, C, Sieweke
Cell 138, 300–313 (2009)

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selected publications:

Characterization of Mouse Adult Testicular Macrophage Populations by Immunofluorescence Imaging and Flow Cytometry
Noushin Mossadegh-Keller and Michael H. Sieweke
Bio-protocol, 2019 , 9, Iss 5

Testicular macrophages: Guardians of fertility
Mossadegh-Keller N, Sieweke MH
Cell Immunol., 2018 , PMID: 29650243

Trained macrophages support hygiene hypothesis
de Laval B, Sieweke MH
Nat Immunol., 2017 , 18(12):1279-1280, PMID: 29144502

Developmental origin and maintenance of distinct testicular macrophage populations
Mossadegh-Keller N, Gentek R, Gimenez G, Bigot S, Mailfert S, Sieweke MH
J Exp Med., 2017 , PMID: 28784628

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SIRT1 regulates macrophage self-renewal
Imperatore F, Maurizio J, Vargas Aguilar S, Busch CJ, Favret J, Kowenz-Leutz E, Cathou W, Gentek R, Perrin P, Leutz A, Berruyer C, Sieweke MH
EMBO J. 2017 , pii: e201695737, PMID: 28701484

M-CSF improves protection against bacterial and fungal infections after hematopoietic stem/progenitor cell transplantation
Kandalla PK, Sarrazin S, Molawi K, Berruyer C, Redelberger D, Favel A, Bordi C, de Bentzmann S, Sieweke MH
J Exp Med., 2016 , 213(11):2269-2279, PMID: 27811055

Eosinophils and mast cells: a lineage apart
Sarrazin S., Sieweke MH.
Nat Immunol., 2016 , 17(6):609-11, PMID: 27196510

Monocytes Compensate Kupffer Cell Loss during Bacterial Infection
Molawi K. and Sieweke MH.
Immunity, 2015 , 42(1), 10-12

Waddington's Valleys and Captain Cook's Islands
Sieweke MH.
Cell Stem Cell, 2015 , 16(1), 7-8, PMID: 25575076

Tissue macrophage identity and self-renewal
Gentek R., Molawi K., Sieweke MH.
Immunol Rev., 2014 , 262(1), 56-73, PMID: 25319327

Progressive replacement of embryo-derived cardiac macrophages with age
Molawi K., Wolf Y., Kandalla PK., Favret J., Hagemeyer N., Frenzel K., Pinto AR., Klapproth K., Henri S., Malissen B., Rodewald HR., Rosenthal NA., Bajenoff M., Prinz M., Jung S., Sieweke MH.
J Exp Med., 2014 , 211(11), 2151-8, PMID: 25245760

Beyond stem cells: self-renewal of differentiated macrophages
Sieweke MH., Allen JE.
Science, 2013 , 342(6161), 1242974, PMID: 24264994

Transcriptional control of macrophage identity, self-renewal, and function
Molawi K., Sieweke MH.
Adv Immunol., 2013 , 120, 269-300, PMID: 24070388

Integration of cytokine and transcription factor signals in hematopoietic stem cell commitment
Sarrazin S., Sieweke M.
Semin Immunol., 2011 , PMID: 21937237

Creating a blood line from human skin
Sieweke, M. H.
Genome Biol, 2010 , 11, 143, PMID: 21172042

Development of macrophages with altered actin organization in the absence of MafB
Aziz, A.
Mol Cell Biol, 2006 , 26, 6808-18, PMID: 16943423

Mutations of brainstem transcription factors and central respiratory disorders
Blanchi, B.
Trends Mol Med, 2005 , 11, 23-30, PMID: 15649819

Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate
Bakri, Y.
Blood, 2004 , 105, 2707-16, PMID: 15598817

MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth
Blanchi, B.
Nat Neurosci, 2003 , 6, 1091-100, PMID: 14513037

MafB is an inducer of monocytic differentiation
Kelly, L. M.
EMBO J, 2000 , 19, 1987-97, PMID: 10790365