Hematopoietic stem cell homeostasis and regulation
Focus
The mammalian hematopoietic system produces enormous numbers of mature blood cells every day and can rapidly adapt to situations of increased blood cell demand, such as infection or blood loss. We are investigating how hematopoietic stem cells (HSCs) and progenitors orchestrate this highly organized and dynamic process. Traditionally, the properties of hematopoietic stem and progenitor cells have been studied primarily through transplantation-based assays. In recent years, however, it has become clear that such experiments rather reveal the potential of the transplanted cells rather than their fate in the natural environment. We use state-of-the-art mouse models (e.g. genetic fate mapping, genetic barcoding, cell cycle reporters, and HSC in vivo depletion) to study how hematopoiesis is maintained within the intact bone marrow niche under steady-state and stress conditions.
Selected publications:
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Munz, C. M., N. Dressel, M. Chen, T. Grinenko, A. Roers and A. Gerbaulet (2023). "Regeneration following blood loss and acute inflammation proceeds without contribution of primitive HSCs" Blood, in press
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Morcos, M. N. F., C. Li, C. M. Munz, A. Greco, N. Dressel, S. Reinhardt, K. Sameith, A. Dahl, N. B. Becker, A. Roers, T. Höfer and A. Gerbaulet (2022). "Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis." Nature Communications 13(1): 4504.
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Sanin, D. E., Y. Ge, E. Marinkovic, A. M. Kabat, A. Castoldi, G. Caputa, K. M. Grzes, J. D. Curtis, E. A. Thompson, S. Willenborg, S. Dichtl, S. Reinhardt, A. Dahl, E. L. Pearce, S. A. Eming#, A. Gerbaulet#, A. Roers#, P. J. Murray# and E. J. Pearce# (2022). "A common framework of monocyte-derived macrophage activation." Science Immunology 7(70): eabl7482. # senior author
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Morcos, M. N. F., T. Zerjatke, I. Glauche, C. M. Munz, Y. Ge, A. Petzold, S. Reinhardt, A. Dahl, N. S. Anstee, R. Bogeska, M. D. Milsom, P. Säwen, H. Wan, D. Bryder, A. Roers and A. Gerbaulet (2020). "Continuous mitotic activity of primitive hematopoietic stem cells in adult mice." Journal of Experimental Medicine 217(6).