Research Projects
Overview of research projects within the IRTG 2251:ICSMD
2nd funding period
|
Project No. |
Title | PI (TUD) | PI (KCL) |
|---|---|---|---|
| Research area A. ß-cell proliferation, recovery, regeneration, and differentiation | |||
| 1 | Dissecting the pro-proliferative role of the ICA512-STAT5 pathway in ß-cells during pregnancy | Michele Solimena |
Rocio Sancho; David Hopkins |
| 2 | Functional β-cell recovery in T2D | Stephan Speier | Peter Jones |
| 3 | Signals for in vivo β-cell regeneration | Nikolay Ninov |
Timothy Pullen; Shanta Persaud |
| 4 | Mesenchymal and endothelial signals in the generation of hPSC-derived β-cells | Anthony Gavalas | Francesca Spagnoli |
| Research area B. β-cell viability and function | |||
| 5 | Modelling genes predisposing to diabetes using pancreas organoids | Anne Grapin-Botton | Rocio Sancho; Fiona Watt |
| 6 | Mechanisms and pathophysiological importance of regulated necrosis of pancreatic β-cells | Andreas Linkermann; Ünal Coskun | Christer Hogstrand; Francesco Rubino |
| 7 | Development of a metabolic targeted approach to improve glucose-stimulated insulin synthesis and secretion in pancreatic β-cells | Tiago C. Alves; Barbara Ludwig | Shanta Persaud |
| Research area C. Therapeutig approaches for diabetes | |||
| 8 | T cell receptors for therapy and monitoring | Anne Eugster; Ezio Bonifacio | Timothy Tree; Stephanie Amiel |
| 9 | Generation and characterization of pseudo-islets for β-cell replacement | Barbara Ludwig |
Peter Jones; Aileen King |
| Research area D. Diabetic complications | |||
| 10 | Leptin and leptin receptor signalling in diabetic cardiomyopathy | Kaomei Guan | Cynthia Andoniadou; Geltrude Mingrone |
| 11 | Impact of phosphodiesterase 2A in diabetic cardiomyopathy | Ali El-Armouche; Susanne Kämmerer | Manuel Mayr; Barbara McGowan |
| 12 | Exercise prevents impact of gestational diabetes mellitus on fetal endothelial function | Henning Morawietz | Paul D. Taylor; Lucilla Poston |
| 13 | Characterization of the interplay between metabolic disorders, the neuroendocrine stress system and COVID-19 | Charlotte Steenblock; Stefan Bornstein | Cynthia Andoniadou |
1st funding period
| Project No. | Title | PI (TUD) | PI (KCL) |
|---|---|---|---|
| Research area A. Immune prevention in T1D | |||
| 1 | Regulation vs activation of immune responses to autoantigens | Ezio Bonifacio | Timothy Tree |
| 2 | Presentation of insulin granule derived peptides on MHC I in Enterovirus-infected β-cells and T1D | Michele Solimena | Mark Peakman |
| Research area B. From immune prevention to stem cells | |||
| 3 | Characterising the pancreatic ductal progenitor in ex vivo pancreas slice culture | Stephan Speier | Axel Behrens |
| 4 | Microencapsulation of human PS cell derived β-cells | Anthony Gavalas | Aileen King |
| Research area C. From stem cells to regeneration and cell replacement | |||
| 5 | G-protein-coupled receptors in β-cell regeneration | Nikolay Ninov; Michele Solimena | Shanta Persaud |
| 6 | Small RNA-Seq to reveal islet-miRNA modulation under stress- and transplantation conditions | Anne Eugster; Ezio Bonifazio | Pratik Choudhary; Stephanie Amiel |
| 7 | Macroencapsulation of islets | Barbara Ludwig; Stefan Bornstein | Peter Jones |
| 8 | Introducing the STAT3-Ser/Hes3 signalling axis in the regulation of the hypothalamic-pituitary axis during homeostasis and disease | Kaomei Guan; Andreas Androutsellis-Theotokis | Cynthia Andoniadou |
| Research area D. From ß-cells to peripheral insulin resistance - adipose tissue inflammation in T2D | |||
| 9 | T cell subpopulations in adipose tissue inflammation | Triantafyllos Chavakis | Jane Howard |
| 10 | Hedgehog signaling in defective diabetic wound healing | Suzanne Eaton | Fiona M. Watt |
| Research area E. From inflammation to bariatric surgery | |||
| 11 | Peripheral mechanisms of diabetes remission after metabolic surgery | Andreas Birkenfeld | Geltrude Mingrone |
| 12 | β-cell specific mechanisms of diabetes remission after bariatric surgery | Ünal Coskun; Stefan Bornstein | Francesco Rubino |