Immune-based diagnostic in oncology
Solid and haematological malignancies are highly heterogeneous even within one entity. Novel techniques and an increasing knowledge about tumour biology provide the basis to implement individualized treatment approaches into treatment protocols. In the past years immune-based treatments have successfully improved the outcome of certain cancers. However, there is still a lack of knowledge to fully embrace the potential of utilizing the immune system to treat patients. Our group is working on improving the understanding of how quantifying changes in the immune system can be used to predict a patient's outcome or response to therapy and to individualize a patient's treatment.
Our current work is focussed on how differences in immune reconstitution in patients following haematopoietic stem cell transplantation can identify patients at higher risk of relapse or graft versus host disease (GvHD). A special focus of this work is based on the ability to assess the T cell receptor repertoire using next generation sequencing 1.
- Identify specific changes in the T cell receptor repertoire composition to predict the outcome of patients following stem cell transplantation
- Explore the T cell receptor repertoire composition as a tool to identify patients at risk of GvHD
- Assess the prognostic potential of T cell receptor repertoire analyses in patients receiving immune therapies
LAB MEMBERS
© Marie Brombach
Dr. med. Cornelia Link-Rachner
| POSITIONS AND EDUCATION | |
|---|---|
| since 10/2019 | Mildred-Scheel-Nachwuchszentrum (MSNZ) research group leader affiliated with Bonifacio group at Center for Regenerative Therapies Dresden (CRTD) |
| 2013-2015 | Gerok research position at CRTD (Group Ezio Bonifacio) |
| 2006-2010 | Medical doctorate in the laboratory of Prof. Neubauer, Klinik für Hämatologie/Onkologie/Immunologie, Marburg |
| 2003-2010 | Medical Studies, Philipps-Universität, Marburg |
| CLINICAL TRAINING | |
|---|---|
| since 02/2018 | Consultant Medizinische Klinik 1, Universitätsklinikum Dresden (UKD), Technische Universität Dresden (TUD) |
| 01/2018 | Board certification Internal Medicine |
| 09/2010-02/2018 | Resident Medizinische Klinik 1, UKD, TUD |
| HONORS | |
|---|---|
| 2013-2015 | Gerok Fellowship |
| 2003-2006 |
"Studienstiftung des deutschen Volkes" Scholarship |
LINKS
ORCID
Katja Steinberg-Bains Dipl.Ing. (FH)
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Manisha Goel M.Sc.
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SELECTED PUBLICATIONS
Link-Rachner CS, Eugster A, Rücker-Braun E, Heidenreich F, Oelschlägel U, Dahl A, Klesse C, Kuhn M, Middeke JM, Bornhäuser M, Bonifacio E, Schetelig J. T-cell receptor-α repertoire of CD8+ T cells following allogeneic stem cell transplantation using next-generation sequencing.Haematologica. 2019 Mar;104(3):622-631. PMID: 30262565
Link CS, Hölig K, Rücker-Braun E, Lang K, Kuhn M, Eugster A, Klesse C, Schmiedgen M, Heidenreich F, Oelschlägel U, Dahl A, Bornhäuser M, Bonifacio E, Schetelig J. Assessment of the T cell receptor repertoire in long-term platelet donors by next generation sequencing.Br J Haematol. 2018 May;181(3):389-391. PMID: 28272738
Link CS, Eugster A, Heidenreich F, Rucker-Braun E, Schmiedgen M, Oelschlagel U, Kuhn D, Dietz S, Fuchs Y, Dahl A, Domingues AM, Klesse C, Schmitz M, Ehninger G, Bornhauser M, Schetelig J, Bonifacio E. Abundant cytomegalovirus (CMV) reactive clonotypes in the CD8(+) T cell receptor alpha repertoire following allogeneic transplantation. Clin Exp Immunol 2016 Jun;184: 389-402 PMID: 26800118
Link CS, Mies F, Scheele J, Kramer M, Schetelig J, Ordemann R, Hänel M, Bornhäuser M, Ehninger G, Kroschinsky F. Long-term follow-up of patients with relapsed or refractory non-Hodgkin's lymphoma receiving allogeneic stem cell transplantation. Bone Marrow Transplant. 2016 Nov;51(11):1527-1529. PMID: 27295271
NEWS/ACtivities
CONTACT
© Marc Eisele
Link-Rachner Lab
Visiting address:
CRTD / DFG Center for Regenerative Therapies at the TU Dresden, ? Fetscherstrasse 105
01307 Dresden
Postal address:
TUD Dresden University of Technology CRTD / DFG Center for Regenerative Therapies at the TU Dresden Dr. Cornelia Link-Rachner Fetscherstrasse 105
01307 Dresden