Precision Genome Writing: Three New Reviews by the Buchholz Lab

Take a look at three recent reviews that together outline a complete pipeline for next‑generation genome editing:

Wang P, Sayed S, Buchholz F. Restoring Cancer Genomes: Functional Mutation Correction as a Platform for Precision Oncology. Hum Gene Ther. 2026 Jul 27:10430342261468973. doi: 10.1177/10430342261468973

Buchholz F. A retargeted recombinase for precise insertion of large DNA. Nat Biotechnol. 2026 Jun 29. doi: 10.1038/s41587-026-03198-x

Buchholz F. INSTALLing recombinase-driven genome writing: Engineered single-stranded donors bypass innate immunity to enable large DNA integration. Mol Cell. 2026 May 21;86(10):1836-1838. doi: 10.1016/j.molcel.2026.04.018

In sum, these analyses highlight both the technical progress achieved and the critical hurdles that remain for precise genome writing.