From Genes to Enzymes

Module number BIO-BP-61P04
Module name From Genes to Enzymes
Lecturers Prof. Mascher, Prof. Rother, Prof. Ansorge-Schumacher
Qualification goals
Students know the basic mechanisms of microbial regulation and signal transduction and understand how these processes can be used biotechnologically. They know the domain-specific processes involved in the translation of mRNA into proteins and the processes of specific translation events. Students understand the underlying molecular mechanisms and are able to use them in an applied/biotechnological context. They know the molecular properties and applications of enzymes and understand the relationship between structure and catalytic function. They are able to identify enzyme sources and determine the technical capabilities of enzymes.
Contents
The module covers the molecular principles of bacterial regulation at the level of transcription and translation initiation as well as signal transduction. Furthermore, the mechanistic details of the translation of mRNA into proteins in the three domains of life and the molecular principles of special translation events are included. Further contents are the biochemically/physiologically relevant consequences of special translation events and their biotechnological utilization using selected examples. The module also covers enzyme categories and their significance in terms of application technology, relationships between structural and catalytic properties of selected enzymes and the key parameters of biocatalytic utilization. Classical and modern methods of identifying new enzymes are also included.
Teaching and learning methods
The module comprises lecture (4 SWS), seminar (2 SWS), exercise (1 SWS) and self-study.
Prerequisites for participation
The competences to be acquired in the modules Physiological Concepts of Microbe Cultivation and Microbial Expression Hosts and Protein Production are required.
Applicability
The module is a compulsory module in the Master's degree program Molecular Biosciences and Productive Biosystems.
Requirements for the awarding of credit points
Credit points are awarded if the module examination is passed. The module examination consists of a written examination lasting 90 minutes.
Credit points and grades
Ten credit points can be earned through the module. The module grade corresponds to the grade of the examination.
Frequency of the module
The module is offered every winter semester.
Workload
The total workload is 300 working hours.
Duration of the module
The module lasts one semester.

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