Publikationen

Publications from the Schirmeier lab: https://orcid.org/0000-0001-8431-9593

2026

Müller S, Surina N, Köhler-Solís A, Nellas I, Fleige A, Görtz S, and Schirmeier S (2026) Neuronal loss of the pentose phosphate pathway in the living nervous system is causally linked to [NADPH] reduction and elevated oxidative stress. J. Physiol. | doi.org/10.1113/JP288582

2025

Köhler-Solís A, Schirmeier S (2025) Neuronal metabolism: Surprisingly flexible. Current Biology | doi: 10.1016/j.cub.2025.10.010

Bolaños JP, Alberini CM, Almeida A, Barros LF, Bonvento G, Bouzier‐Sore A, Dringen R, Hardingham GE, Hirrlinger J, Magistretti PJ et al. (2025) Embracing the Modern Biochemistry of Brain Metabolism. Journal of Neurochemistry | doi: 10.1111/jnc.70166

2024

Barros LF, Schirmeier S, Weber B (2024) The Astrocyte: Metabolic Hub of the Brain. Cold Spring Harb Perspect Biol. | doi: 10.1101/cshperspect.a041355

2023

Glycolytically impaired Drosophila glial cells fuel neural metabolism via β-oxidation. By: McMullen, E., Hertenstein, H., Strassburger, K., Deharde, L., Brankatschk, M., & Schirmeier, S. | Nature Communications | Volume: 14, Issue 1 | doi: 10.1038/s41467-023-38813-x

2022

Single-Fluorophore Indicator to Explore Cellular and Sub-cellular Lactate Dynamics.; By: Aburto C, Galaz A, Bernier A, Sandoval PY, Holtheuer-Gallardo S, Ruminot I, Soto-Ojeda I, Hertenstein H, Schweizer JA, Schirmeier S, Pástor TP, Mardones GA, Barros LF, San Martín A | ACS Sensors | Volume: 7, Issue 11 | doi: 10.1021/acssensors.2c00731

Genetically Encoded Sensors to Study Metabolism in Drosophila.; By: Ellen McMullen, Helen Hertenstein, Stephan Müller, Stefanie Schirmeier. | Drosophila: Methods and Protocols| Part of the Methods in Molecular Biology book series (MIMB,volume 2540:401-414) | doi: 10.1007/978-1-0716-2541-5_21

2021

Starvation-induced regulation of carbohydrate transport at the blood–brain barrier is TGF-β-signaling dependent.; By: Hertenstein H, McMullen E, Weiler A, Volkenhoff A, Becker HM & Schirmeier S | Elife | Volume: 10 | e62503

Plasticity of Carbohydrate Transport at the Blood-Brain Barrier; By: McMullen, Ellen, Weiler A, Becker HM, Schirmeier S; Frontiers in Behavioral Neuroscience | Volume: 14 | 271 |

2020

AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival.  Muraleedharan, Ranjithmenon, Gawali, Mruniya V , Tiwari, Durgesh, Sukumaran, Abitha , Oatman, Nicole, Anderson, Jane, Nardini, Diana, Bhuiyan, Mohammad Alfrad Nobel, Tkáč, Ivan, Ward, Amber Lynne , Kundu, Mondira, Waclaw, Ronald, Chow, Lionel M, Gross, Christina, Rao, Raghavendra, Schirmeier, Stefanie, Dasgupta, Biplab; Cell Reports | Volume: 32 | Issue: 9

ATF4-Induced Warburg Metabolism Drives Over-Proliferation in Drosophila. Sorge, Sebastian, Theelke, Jonas, Yildirim, Kerem, Hertenstein, Helen, McMullen, Ellen, Müller, Stephan, Altbürger, Christian, Schirmeier, Stefanie, Lohmann, Ingrid; Cell Reports | Volume: 31 | Issue: 7 | 107659

A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC. Arce-Molina R, Cortés-Molina F, Sandoval PY, Galaz A, Alegría K, Schirmeier S, Barros LF, San Martín A; eLife | Volume: 9

Neuron–glia interaction in the Drosophila nervous system. Bittern, Jonas, Pogodalla, Nicole, Ohm, Henrike, Brüser, Lena, Kottmeier, Rita, Schirmeier, Stefanie, Klämbt, Christian; Developmental Neurobiology

2018

Live imaging using a FRET glucose sensor reveals glucose delivery to all cell types in the Drosophila brain. Volkenhoff A, Hirrlinger J, Kappel JM, Klämbt C, Schirmeier S; Journal of Insect Physiology |

Quorum‐sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization. Haller S, Franchet A, Hakkim A, Chen J, Drenkard E, Yu S, Schirmeier S, Li Z , Martins N , Ausubel FM, Liegeois S, Ferrandon ;EMBO reports | e44880

2017

Glial Cell Evolution: The Origins of a Lipid Store. Nave KA, Tzvetanova ID, Schirmeier S; Cell Metabolism | Volume: 26 | Issue: 5 | 701-702

Insect models of central nervous system energy metabolism and its links to behavior. Rittschof CC, Schirmeier S; Glia |

Metabolite transport across the mammalian and insect brain diffusion barriers. Weiler A, Volkenhoff A, Hertenstein H, Schirmeier S; Neurobiology of Disease | Volume: 107 | 15-31 |

2016

Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack. Lee KZ, Lestradet M, Socha C, Schirmeier S, Schmitz A, Spenlé C, Lefebvre O, Keime C, Yamba WM, Bou Aoun R, Liegeois S, Schwab Y, Simon-Assmann P, Dalle F, Ferrandon D; Cell Host and Microbe | Volume: 20 | Issue: 6 | 716-730 |

Axon ensheathment and metabolic supply by glial cells in Drosophila. Schirmeier S, Matzat T, Klämbt C; Brain Research | Volume: 1641 | 122–129

2015

The Drosophila blood-brain barrier as interface between neurons and hemolymph. Schirmeier S, Klämbt C; Mechanisms of Development | Volume: 138 | 50–55

Glial glycolysis is essential for neuronal survival in Drosophila. Volkenhoff A, Weiler A, Letzel M, Stehling M, Klämbt C, Schirmeier S; Cell Metabolism | Volume: 22 | Issue: 3 | 437-447 |

2014

The Drosophila blood-brain barrier: Development and function of a glial endothelium. Limmer S, Weiler A, Volkenhoff A, Babatz F, Klämbt C; Frontiers in Neuroscience | Volume: 8 | 365 |

Closing the gap between glia and neuroblast proliferation. Limmer S, Klämbt C; Developmental Cell | Volume: 30 | 249–250

2011

Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model. Limmer S, Haller S, Lee J, Yu S, Kocks C, Ausubel FM, Ferrandon D; Proceedings of the National Academy of… | Volume: 108 | Issue: 42 | 17378–17383

Virulence on the fly: Drosophila melanogaster as a model genetic organism to decipher host-pathogen interactions. Limmer S, Quintin J, Hetru C, Ferrandon D; Current Drug Targets | Volume: 12 | 978–999

2009

Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Cronin SJF, Nehme NT, Limmer S, Liegeois S, Pospisilik JA, Schramek D, Leibbrandt A, de Matos Simoes R, Gruber S, Puc, Urszula, Ebersberger I, Zoranovic T, Neely GG, von Haeseler A, Ferrandon D, Penninger JM; Science | Volume: 325 | Issue: 5938 | 340-343