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What we are doing
We are currently trying to understand which transporters are needed to distribute carbohydrates, lactate and alanine between the different neural cell types. To this end, we analyze transporter expression and specificities in the nervous system. We further aim on understanding how the amounts of carbohydrate taken up from circulation and of lactate/alanine transferred to the neurons are dynamically adapted to the neuronal needs. We use the genetic strength of Drosophila to unravel the underlying regulatory mechanisms that allow neuron-glia communication and modulate nutrient uptake and distribution.