2017 - Natural compounds: From molecular mechanisms to applications
Table of contents
Dresden/Gohrisch, September 7th - 14th 2017
General aim of the advanced training
The aim of the advanced training activity is to consolidate previously acquired knowledge, to highlight important developments within the scientific field and to create a platform to discuss novel findings of the participating scientists. Amongst others, new data are available in the literature regarding molecular mechanisms of function of many products and compounds which have been discussed in previous Alumni meetings at TU Dresden. It is therefore an additional aim of this workshop to discuss these findings not only regarding their potential consequences regarding efficacy and safety in case of human applications, but also to identify new fields of applications both for known and novel products/extracts/compounds.
Content
The 48 nuclear receptors of humans, comprising receptors for female and male sexual hormones as well as lipid sensors, represent relevant target structures for natural compounds and selected synthetic drugs. The interactions of medicinal plant extracts, dietary supplements or single compounds derived thereof with these receptors and the resulting functional consequences are relevant for the treatment or prevention of age related symptoms and diseases (e.g. menopausal complaints, diabetes mellitus, hypertension, obesity or cancers). For attenuation of symptoms or the prevention of disease, medicinal plants play an important role, particularly in developing countries, where they often represent the only affordable medication.
In the past years, some knowledge gaps regarding efficacy and/or safety of individual plant extracts/compound groups could be closed. A knowledge gain towards the molecular mechanism of function could be achieved for products or individual substances, which are available as medicinal plant extracts or dietary supplements. One aim of the symposium is therefore to introduce and to discuss novel findings in the field of efficacy and safety of natural compounds within the group of participants.
Medicinal plant extracts and dietary supplements comprise complex mixtures of compounds. Pharmacological, toxicological and endocrinological “tool boxes” suitable to assess and to characterize single, individual compounds are sometimes inefficient or not suitable at all for the assessment of complex mixtures. The second focus of this meeting will therefore discuss the question of suitable pharmacological, toxicological and endocrinological approaches to assess efficacy and safety of mixtures. If possible, in this area preference should be given to those extracts and products which may have the potential for application.
The availability and use of data generated from basic experimental research to the general public is limited. However there is a consensus amongst scientists that the awareness of research findings by the public, representing the tax payer, in various aspects is fundamentally important. A central question of this meeting will touch the question of how to improve dissemination of the created data. A good example for efficient dissemination comes from the area of consumer protection. In Europe in the meantime two opinions have been released by the European Food Safety Authority (EFSA) on substance classes, which have extensively been discussed in previous Alumni Meetings at TU Dresden, namely Bisphenol A and soy isoflavones. While communication platforms to consumers to some degree may exist in Europe, to date there are no such tools in developing countries. There are no means to convey scientific knowledge back to healers or users of traditional medicinal products in third world countries. Therefore, it is of importance to discuss with participants from developing countries potential tools of dissemination of scientific knowledge. To address this issue, a round table discussion will be arranged.
Format of the meeting
The backbone of the scientific meeting will be the contributions of the participants. Participants are encouraged to actively participate in this workshop. They are asked to provide a seminar talk or a short communication on novel achievements in her/his area of research, as well as a written abstract.
Each scientific sub section will be introduced by a plenary lecture. A special key note lecture will highlight a particularly hot topic in the field. The issue of data dissemination beyond scientific publication with special emphasis on how to address the public will be addressed in a round table discussion. Overall, the meeting will comprise:
1 keynote lecture
6 plenary lectures
25 (approx.) seminar and short lectures
1 round table discussion
Schedule
Dresden: 8 – 9 September, Networking and Cultural Activities
Thursday, 7 September 2017 |
Arrival in Dresden |
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Friday, 8 September 2017 |
9:30 – 12:30 |
Registration and Financial Issues (Cash Payment of travel grants) Venue: Zellescher Weg 12-14, 01069 Dresden, Willersbau Room C 207, Description with pictures: http://www.math.tu-dresden.de/sto/schilling/arrival_from_train_station.pdf 11:00 – 11.15 Opening with presentation of the Department Biology, Prof. Dr. Ansorge-Schumacher, Dean of Studies 11:15 – 11:30 Presentation of the School of Science, Nicole Gierig, Public Relations Advisor of the School of Science 11:30 – 11:45 Presentation of TU Dresden, Prof. Dr. Gerhard Rödel, Vice-Rector for Research, TU Dresden 11:45 – 12:00 Presentation of the Welcome Center TU Dresden, Claudia Reichert, Services for International Researchers |
12:30 – 13:30 |
Lunch |
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13:30 – 14:30 |
Campus Tour |
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15:00 – 17:00 |
Presentation Block on TU Dresden, Alliance Dresden Concept and Funding Opportunities for further cooperation Venue: Zellescher Weg 12-14, 01069 Dresden, Willersbau Room C 207, Description with pictures: http://www.math.tu-dresden.de/sto/schilling/arrival_from_train_station.pdf |
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Saturday, 9 September 2017 |
11:00 – 14:00 |
Networking Brunch with Dresden Scientists Venue: Zellescher Weg 12-14, 01069 Dresden, Willersbau Room C 207, Description with pictures: http://www.math.tu-dresden.de/sto/schilling/arrival_from_train_station.pdf |
14:00 – 18:30 |
Scientific Tour |
Gohrisch: 10 – 13 September 2017, Scientific Retreat
Sunday, 10 |
Transfer to Gohrisch, Sächsische Schweiz |
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10:00 |
Start Trip to Sächsische Schweiz, Meeting Point: International Guest House, Hochschulstraße 50 Excursion, including Lunch at Brandbaude |
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16:00 |
Check in in Retreat Hotel Margaretenhof (Gohrisch) |
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Opening of the scientific symposium |
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17:00 – 17:30 |
Günter Vollmer, Scientific organizer |
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17:30 – 18:30 |
Flash Talks for Introduction |
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19:00 |
Welcome Barbecue |
Monday, 11 September 2017 |
09:00 – 09:45 |
Plenary lecture Michael Heinrich, University College London, School of Pharmacy, London UK Beyond mixture effects -The complexity of herbal medicines and botanicals |
09:45 - 10:15 |
Traditional use Thea Lautenschläger, Institute for Botany, Technische Universität Dresden Recording traditional use of plants in Uíge Province, Northern Angola |
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10:15 – 10:40 |
Coffee break | |
10:40 – 11:00 |
Maya Doukoure, Cell Physiology & Endocrinology, Universtity of Ouagadougou, Burkina Faso Ethnobotanical survey and biological activities of two lactogenic plants in the Cascades region of BURKINA FASO |
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11:00 – 11:40 |
New plants, extracts and compounds Maria Halabalaki, University of Athens, Laboratory of Pharmacognosy and Natural Products, Athens, Greece Pistacia : exploration of a unique genus with exceptional pharmacological properties |
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11:40 – 12:10 |
Milen Georgiev, Bulgarian Academy of Sciences, Plovdiv, Bulgaria Natural products isolation and metabolomics and their use in accelerated lead finding and presentation of a new EU funded project |
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12:10 – 12:40 |
Kinya Akashi, Faculty of Agriculture, Tottori University, Tottori, Japan Wild watermelon and the related plant resources in the Kalahari Desert, Botswana: Citrulline metabolism and its physiological effects |
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12:40 -13:45 | Lunch break | |
13:45-14:15 |
Analytics Andriana Trifan, Department of Pharmacognosy, University of Medicine and Pharmacy "Grigore T. Popa", Iasi, Romania Qualitative analysis of phenolic compounds in the roots of Symphytum officinale L. by UPLC-DAD-QTOF-MS/MS |
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14:15-14:45 |
Alireza Ghassempour, Analytical Chemistry, Shahid Behshti University, Evin, Tehran, Iran Mass Spectrometry for Monitoring of Natural Compounds |
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15:15 – 18:30 |
Excursions alternatively Walk around the village or leisure |
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19:00 | Dinner |
Tuesday, 12 September |
09:00 – 09:430 |
Biotechnology Plenary lecture 2 Andreana Assimopoulou, Aristotle University of Thessaloniki, Department of Chemical Engineering, Greece Technological Exploitation of Natural Products |
09:30 – 09:50 |
Livia Dias, University of Campinas; Laboratory of Bioprocess, São Paulo, Brazil A New Biotechnological Process to Enhance the Soymilk Bioactivity |
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09:50– 10:30 |
Mixtures Julia T. Arnold, Ellicott City, Maryland, USA Indian Ayurvedic Medicinal Plants for Health Promotion and for Prevention and Treatment of Cancer |
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10:30 - 11.00 | Coffe break | |
11:00 - 11-40 |
Daniela Schuster, IPCI Computer Aided Molecular Design Group, University of Innsbruck, Austria The polypharmacology of chemicals targeting the endocrine system |
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11:40 - 12:20 |
Maarten Bosland, Department of Pathology, University of Illinois at Chicago, Chicago, USA Soy and black raspberries and prostate cancer: Experimental studies of whole extracts versus components and interactions with chemotherapy |
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12:20-13:30 | Lunch break | |
13:30-14:10 |
Receptors and signaling pathways Georg Kretzschmar, TU-Dresden Estrogen regulated microRNAs - miR-203 as an example |
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14:10–14:40 |
Dana Macejova, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic Approaches to study retinoid/retinoid-X receptors in physiological and pathophysiological processes |
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14:40-15:00 |
Adolfo Rivero-Müller, Medical University of Lublin, Lublin Poland and Turku Centre for Biotechnology, Turku, Finland What does two exceptionally rare mutations tell us about the structural/molecular mechanisms of the pituitary-gonadal axis? |
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15:00-15:30 | Leisure | |
15:30–16:00 |
Ann Louw, Department of Biochemistry, Stellenbosch University, South Africa Cyclopia extract, SM6Met: the Oestrogen Receptor and beyond |
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16:00–16:30 |
Stefano Lorenzetti, ISS - Istituto Superiore di Sanità, Rome, Italy Plant bioactives and male fertility: the importance of targeting an accessory gland |
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16:30–17:00 | Leisure | |
17:00–17:40 |
Menopause Annekathrin Keiler, Institute of Doping Analysis und Sports Biochemistry, Kreischa and TU Dresden The rat as model for research on prevention and treatment of postmenopausal osteoporosis |
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17:40–18:00 |
Basile Tindano, Cell Physiology & Endocrinology, Universtity of Ouagadougou, Burkina Faso Can antioxidant and phyto-hormonal activities of hydro-alcoholic extract of Pentadesma butyracea leaves contribute to hormone replacement therapy? |
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18:00–18:30 |
Sefirin Djiogue, Faculty of Science, University of Yaounde, Cameroon Pueraria phaseoloides (Fabaceae) extracts, alleviates hot flashes and reduced anxiety on ovariectomized Wistar rats |
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18:30 | Dinner and end of day | |
Wednesday, 13 September 2017 | 09:00 – 09:30 |
Dietary constituents Oliver Zierau, TU Dresden Acceptance of tannin-rich diets in three captive ape species |
09:30 – 10:00 |
Alternative Tools, Targets and Strategies Adolfo Rivero-Müller, Medical University of Lublin, Lublin Poland and Turku Centre for Biotechnology, Turku, Finland How to train your cell: by light |
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10:00 – 10:30 |
Federico Jensen, National University Arturo Jauretche and Center for Pharmacological and Botanical Studies (CEFYBO-CONICET-UBA), Buenos Aires, Argentina Maternal immune adaptations triggered during pregnancy : the role of B lymphocytes |
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10:30 – 11:00 | Coffee break | |
11:00-11.30 |
Marselina I. Tan, School of Life Sciences and Technology, Instittut Teknologi Bandung, Indonesia Topoisomerase Inhibition and Cytotoxic Activities of Cabai Jawa Fruit Extract (Piper retrofractum Vahl.) and Its two Isolates |
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11:30 – 12:00 |
Balé Bayala, Cell Physiology & Endocrinology, Universtity of Ouagadougou, Burkina Faso Anthelmintic activity of Acacia nilotica var adansonii (Guill. et Perr.) O. Ktze and Acacia raddiana (Savi) extracts evaluated in vitro tests |
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12:00 – 12:30 |
Nermin Salah Ahmed, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo City, Egypt An alternative prodrug approach to improve pharmacogenomic susceptibility of tamoxifen and its flexible analogues |
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12:30-13:30 | Lunch break | |
14:00 |
Evaluation |
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15:00 | Transfer back to Dresden | |
Thursday, 14 September 2017 | Departure |
Financial issues
- Travel costs:
We can reimburse your travel costs depending on your country of origin.
Please, have a look at the DAAD-list https://www.daad.de/medien/ausland/dokumente/reisekostenpauschalen-kongress-vortragsreisen.pdf and figure out the maximum amount we may reimburse.
In the case that reimbursement amount according to the DAAD-list is not being sufficient, please feel free to contact our International Office, Maria Richter-Babekoff, e-address .
Please, make your travel arrangements by yourself.
- Per diem:
You will receive a per diem amount to support your housing and living expenses:
95 EUR per day for all the six days of the meeting
Plus
95 EUR (for the day of your arrival and departure)
In case you arrive on September 7th and leave on September 14 th, you will get the full amount of 665 EUR.
Please note that your participation can be funded only if you stay longer than four days.
Contact
International Affairs Advisor
NameMaria Richter-Babekoff M.A.
Send encrypted email via the SecureMail portal (for TUD external users only).
Visitors' Address:
Walther-Hempel-Bau, room A 307 Mommsenstraße 4
01069 Dresden
Office hours:
- Monday:
- 14:00 - 18:00
- Tuesday:
- 13:00 - 16:00
- Wednesday:
- 13:00 - 16:00
Please make an appointment for my consultation hours in advance