Prof. Shu-Chen Li, Ph.D.

Shu-Chen Li promovierte 1994 an der University of Oklahoma (USA) und war danach bis 1995 Postdoktorandin an der McGill University (Canada). Anschließend arbeitete sie am Max-Planck-Institut für Bildungsforschung (MPIB) in Berlin bis August 2012, unter anderem als Projektleiterin des Projekts „Neuromodulation of Lifespan Cognition“. Seit September 2012 leitet sie den Lehrstuhl Entwicklungspsychologie und Neurowissenschaft der Lebensspane an der Technische Universität Dresden. Shu-Chen Li ist Mitglied der „Editorial Board“ von NeuroImage und Neuroscience & Biobehavioral Reviews.

Ihr Forschungsschwerpunkt befasst sich mit der menschlichen Entwicklung über die Lebensspanne. Insbesondere untersucht sie die neurobiologischen und kontextualen Mechanismen kognitiver, motivationaler und emotionaler Entwicklung von der frühen Kindheit bis ins hohe Alter. Ein zentraler Fokus liegt dabei auf dem Zusammenspiel zwischen neuronalen (z. B. neurotransmittersystembezogenen) und kontextuellen (z. B. belohnungs- oder stressbezogenen) Modulatoren.

• Neurokognitive und Verhaltensentwicklung über die Lebensspanne
• Entwicklungsplastizität und Gehirnplastizität über die Lebensspanne
• Neuroökonomie und Altern
• Neuronale Netzwerke und formale Modellierung der Kognition
• Stress und Entwicklung über die Lebensspanne
• Biokulturelle Ko-Konstruktion von Entwicklung

Adelhöfer, N., Gohil, K., Passow, S. Roessner, V., Li, S-C., & Beste, C. (2018). The system-neurophysiological basis for how methylphenidate modulates perceptual-attentional conflicts during auditory processing. Human Brain Mapping, 39, 5050-5061

Rodriguez-Buritica, J. M. , Heekeren, H. R., Li, S.-C., Eppinger, B. (in press). Developmental differences in the neural dynamics of observational learning. Neuropsychologia.

Ilg, L., Klados, M., Alexander, N., Kirschbaum, C., & Li, S. C. (2018). Long-term impacts of prenatal synthetic glucocorticoids exposure on functional brain correlates of cognitive monitoring in adolescence. Scientific reports, 8(1), 7715.

Beste, C., Adelhöfer, N., Gohil, K., Passow, S., Rößner, V., Li, S.-C. (2018). Dopamine modulates the efficiency of sensory evidence accumulation during perception decision making. The International Journal of Neuropsychopharmacology. 21(7), 649–655.

Wittkuhn, L., Eppinger, B., Bartsch, L. M., Thurm, F., Korb, F. M., & Li, S. C. (2018). Repetitive transcranial magnetic stimulation over dorsolateral prefrontal cortex modulates value-based learning during sequential decision-making. NeuroImage, 167, 384-395.

Schuck, N. W., Petok, J. R., Meeter, M., Schjeide, B. M. M., Schröder, J., Bertram, L., ... & Li, S. C. (2018). Aging and a genetic KIBRA polymorphism interactively affect feedback-and observation-based probabilistic classification learning. Neurobiology of aging, 61, 36-43.

Eppinger, B., Heekeren, H. R., & Li, S.-C. (2017). Age differences in the neural mechanisms of intertemporal choice under subjective decision conflict. Cerebral Cortex.

Reiter, A., Eppinger, B., Kanske, P. & Li, S.-C. (2017). The aging of the social mind: differential effects on components of social understanding. Scientific Reports, 7, 11046, 1- 8.

Stankevich, Y., Thurm, F.  Evens, R., Fauser, M., Riedel, O. Storch, A., Li, S.-C. & Lueken, U. (2017).  Dysphoria, dopaminergic medication and spatial memory in Parkinson’s disease. Neuropsychoiatry, 7(3), 281-289.

FitzGerald, T.H.B., Hämmerer, D., Friston, K. J., Li, S.-C. & Dolan, R. J. (2017). Sequential inference as a mode of cognition and its correlations in fronto-parietal and hippocampal brain regions. PLOS Computational Biology.

Eppinger, B., Walter, M. & Li, S.-C. (2017). Electrophysiological correlates reflect the integration of model-based and model-free decision information. Cognitive, Affective & Behavioral Neuroscience. [Epub ahead DOI 10.3758/s13415-016-0487-3]

Passow, S., Thurm, F. & Li, S.-C. (2017). Activating developmental reserve capacity via cognitive training or non-invasive brain stimulation: potentials for promoting fronto-parietal and hippocampal-striatal network functions in old age. Frontiers in Aging Neuroscience, 9, Article 33.

Nassar, M. R., Bruckner, R., Gold, J. I., Heekeren, H. R., Li, S.-C., & Eppinger, B. (2016). Knowing what you don’t know: Age-related deficits in representing uncertainty. Nature Communications, vol. 7, 11609, 1-13.

Thurm, F., Schuck, N. W., Fauser, M., Doeller, C. F., Stankevich, Y., Evens, R., Riedel, O., Storch, A., Lueken, U., & Li, S.-C. (2016). Dopamine modulation of spatial memory in Parkinson’s disease. Neurobiology of Aging, 38, 93-103. doi: 10.1016/j.neurobiolaging.2015.10.019

Schuck, N. W., Doeller, C. F., Polk, T. A., Lindenberger, U. & Li, S.-C. (2015). Human aging alters the neurocomputation and representation of space. NeuroImage, 117(15), 141-150. doi: 10.1016/j.neuroimage.2015.05.031

Garrett, D. D., Nagel, I. E., Preuschhof, C., Burzynska, A. Z., Marchner, J., Wiegert, S., Jungehülsing, G., Nyberg, L., Villringer, A., Li, S.-C., Heekeren, H. R., Bäckman, L. & Lindenberger, U. (2015). Amphetamine modulates brain signal variability and working memory in younger and older adults. Proceedings of the National Academy of Sciences of the USA, 112(24), 7593-7598. doi: 10.1073/pnas.1504090112

Buritica, J. M. R., Eppinger, B., Schuck, N. W., Heekeren, H. R. & Li, S.-C. (2015). Electrophysiological correlates of observational learning in children. Developmental Science, 1-11. doi: 10.1111/desc.12317

Eppinger, B., Heekeren, H. R. & Li, S.-C. (2015). Aging-related prefrontal impairments implicate deficient prediction of future reward in older adults. Neurobiology of Aging, 36(8), 2380–2390. doi:10.1016/j.neurobiolaging.2015.04.010

Liu, T., Li, S.-C., Papenberg, Schröder, J., Roehr, J. T., Nietfeld, W., Lindenberger, U. & Bertram, L. (2014). No association between CTNNBL1 and episodic memory performance. Translational Psychiatry, 4, e454. doi:10.1038/tp.2014.93

Li, S.-C. & Rieckmann, A. (2014). Neuromodulation and aging: implications of aging neuronal gain control on cognition. Current Opinion in Neurobiology, 29, 148-158. doi:10.1016/j.conb.2014.07.009

Papenberg, G., Bäckman, L., Nagel, I. E., Wilfried, N., Schröder, J., Bertram, L., Heekeren, H. R., Lindenberger, U., & Li, S.-C. (2014). COMT polymorphism and memory dedifferentiation in old age. Psychology and Aging, 29(2), 374-383. doi:10.1037/a0033225

Störmer, V., Eppinger, B., Li, S.-C. (2014). Reward speeds up and increases consistency of selective visual attention: a lifespan comparison. Cognitive, Affective, and Behavioral Neuroscience, 14(2), 659-671. doi:10.3758/s13415-014-0273-z

Papenberg, G., Li, S.-C., Nagel, I. E., Nietfeld, W., Schjeide, B.-M., Schröder, J., Bertram, L., Heekeren, H. R., Lindenberger, U., & Bäckman, L. (2014). Dopamine and glutamate receptor genes interactively influence episodic memory in old age. Neurobiology of Aging, 35(5), 1213.e3–1213.e8. doi:10.1016/j.neurobiolaging.2013.11.014

Passow, S., Westerhausen, R., Hugdahl, K., Wartenburger, I., Heekeren, H. R., Lindenberger, U., & Li, S.-C. (2014). Electrophysiological correlates of adult age differences in attentional control of auditory processing. Cerebral Cortex, 24, 249-260. doi:10.1093/cercor/bhs306

Papenberg, G., Haemmerer, D., Müller, V., Lindenberger, U. & Li, S.-C. (2013). Lower theta inter-trial phase coherence during performance monitoring is related to higher reaction time variability: a lifespan study. NeuroImage, 83, 912-920. doi:10.1016/j.neuroimage.2013.07.032

Li, S.-C. (2013). Neuromodulation and developmental contextual influences on neural and cognitive plasticity across the lifespan. Neuroscience & Biobehavioral Reviews, 37(9), 2201-2208. doi:10.1016/j.neubiorev.2013.07.019

Schuck, N. W., Frensch, P. A., Schjeide, R.-M. M., Schröder, J., Bertram, L. & Li, S.-C. (2013). Effects of aging and dopamine genotypes on the emergence of explicit memory during sequence learning. Neuropsychologia, 51(13), 2757-2769. doi:10.1016/j.neuropsychologia.2013.09.009

Schuck, N. W., Doeller, C. F., Schjeide, B.-M., Scjröder, J., Frensch, P. A., Bertram, L., & Li, S.-C. (2013). Aging and KIBRA/WWC1 genotype affect spatial memory processes in a virtual navigation task. Hippocampus, 23(10), 919-930. doi:10.1002/hipo.22148

Li, S.-C., Passow, S., Nietfeld, W., Schröder, J., Bertram, L., Heekeren, H. R. & Lindenberger, U. (2013). Striatal dopamine modulates attentional control of auditory perception: DARPP-32 genotype effects on behavioral and cortical evoked potentials. Neuropsychologia, 51(8), 1649-1661. doi:10.1016/j.neuropsychologia.2013.04.005

Li, S.-C., Papenberg, G., Nagel, I. E., Preuschhof, C., Schröder, J. Nietfeld, W., Bertram, L., Heekeren, H. R. Ulman, L., & Bäckman, L. (2013). Aging magnifies the effects of dopamine transporter and receptor genes on backward serial memory. Neurobiology of Aging, 34(1), 358.e1–358.e10. doi:10.1016/j.neurobiolaging.2012.08.001

Li, S.-C. (2013). Lifespan development of neuromodulation of adaptive control and motivation as an ontogenetic mechanism for developmental niche construction. Developmental Science, 16(2), 317-319. doi:10.1111/desc.12032

Eppinger, B., Hämmerer, D., & Li, S.-C. (2011). Neuromodulation of reward-based learning and decision making in human aging. Annals of the New York Academy of Sciences, 1235(1), 1-17. doi:10.1111/j.1749-6632.2011.06230.x

Li, S.-C., Lindenberger, U., Hommel, B., Aschersleben, G., Prinz, W., & Baltes, P. B. (2004). Transformations in the couplings among intellectual abilities and constituent cognitive processes across the life span. Psychological Science, 15(3), 155-163. doi: 10.1111/j.0956-7976.2004.01503003.x

Li, S.-C. (2003). Biocultural orchestration of developmental plasticity across levels: The interplay of biology and culture in shaping the mind and behavior across the lifespan. Psychological Bulletin, 129(2), 171-194. doi:10.1037/0033-2909.129.2.171

Li, S.-C., Lindenberger, U., & Sikström, S. (2001). Aging cognition: From neuromodulation to representation. Trends in Cognitive Sciences, 5(11), 479-486. doi:10.1016/S1364-6613(00)01769-1