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Characteristics of antibiotics - Application of the TTC test for the detection of antibiotic resistance in a creek biofilm and influence of pH on the desorption characteristics of an- tibiotic compounds from different sediments
Art der Abschlussarbeit
Master
Autoren
- Benisch, Jakob
Betreuer
- Dipl.-Ing. Thomas Käseberg
- Prof. Dr. sc. techn. Peter Krebs
Abstract
Adverse effects of antibiotics on the aquatic environment have been reported recently ranging from toxic effects to the increased devel- opment of multiresistance to antibiotics in bacteria (Martinez 2009; Kümmerer 2009; Czekalski et al. 2012; Caucci & Berendonk 2014). Com- partments of the wastewater system can be seen as one of the main sources of their release into the environment, as these antibacteri- al compounds are not totally degraded in conventional wastewater treatment plants or enter open water bodies directly by discharge of combined sewer overflows (CSO) (Michael et al. 2013; Kümmerer 2009). In order to be able to quantify the contribution of a CSO to the de- velopment of antibiotic resistances in bacterial biofilm, a method, based on a modified TTC test, has been introduced. The method showed good results, however the effect of the CSO could not be estimated due to external influences on the sampling site. Additionally, in- vestigations were carried out to assess the magnitude of antibiotic desorption caused by addition of water with varying pH from creek and sewer sediments. The sewer sediment was furthermore divided into its clay fraction and the rest of the sewer sediment. Dependency of desorption on the pH was only detectable for some compounds from the sewer sediment. However, overall differences between the single sed- iments were cognizable, as well as uncertainties arising most proba- bly from the measuring analytic.
Schlagwörter
antibiotics, TTC test, biofilm, desorption, pH
Berichtsjahr
2014