FINE-TUNING OF KINESINS AND MAPS

Publications

Primary Research Articles

| Kinesins

Kif15 functions as an active mechanical ratchet
McHugh T, Drechsler H, McAinsh AD, Carter NJ, Cross RA
Mol Biol Cell. 2018 Jul 15;29(13):1743-1752. | Open Access |CC BY-NC-SA 3.0 |

The enterohaemorrhagic Escherichia coli effector EspW triggers actin remodeling in a Rac1 dependent manner
Sandu P, Crepin VF, Drechsler H, Frankel G, Berger CN
Infect Immun. 2017 Aug 18;85(9):e00244-17. |Open Access | CC BY 4.0 |

Kinesin-12 motors cooperate to suppress microtubule catastrophes and drive the formation of parallel microtubule bundles
Drechsler H*, McAinsh AD*
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1635-44. |Open Access |

Yeast GSK-3 kinase regulates astral microtubule function via phosphorylation
of the microtubule-stabilising kinesin Kip2
Drechsler H, Tan AN,  Liakopoulos D
J Cell Sci. 2015 Nov 1;128 (21):3910-21. |Open Access | CC BY 4.0 |

The Kinesin-12 Kif15 is a processive track-switching tetramer
Drechsler H, McHugh T, Singleton MR, Carter NJ, McAinsh AD
Elife. 2014 Mar 25;3:e01724. |Open Access | CC BY 3.0 |

| Microtubule Associated Proteins

Multivalent electrostatic microtubule-interactions of synthetic peptides are
sufficient to mimic advanced MAP-like behaviour
Drechsler H*,  Xu Y, Geyer VF, Zhang Y, Diez S*
Mol Biol Cell. 2019 Nov 15;30(24):2953-2968. | Open Access |CC BY-NC-SA 3.0 |
Recommended by Faculty Opinions

Mps1 regulates kinetochore-microtubule attachment stability via the Ska complex to ensure error-free chromosome segregation
Maciejowski J, Drechsler H, Grundner-Culemann K, Ballister ER, Rodriguez-Rodriguez JA, Rodriguez-Bravo V, Jones MJK, Foley E, Lampson MA, Daub H, McAinsh AD, Jallepalli PV Dev Cell. 2017 April 24;41(2):143-56. |Open Access |
Recommended by Faculty Opinions

| Cytoskeleton in Disease

The ALS-Associated FUS (P525L) Variant Does Not Directly Interfere with Microtubule-Dependent Kinesin-1 Motility.
Seifert, A.; Drechsler, H.; Japtok, J.; Korten, T.; Diez, S.; Hermann, A.
Int J Mol Sci. 2021 Feb 28;22(5):2422. |Open Access | CC BY 4.0 |

Reviews

Chapter 11: The Kinesin-15 Family
Drechsler H, Grewal JS, McAinsh AD
The Kinesin Superfamily Handbook: Transporter, Creator, Destroyer (Claire Friel, Ed.), 1st Edition (2020). CRC Press.  | Open Access PDF|

Exotic mitotic mechanisms.
Drechsler H and McAinsh AD
Open Biol. 2012 Dec 5;2(12):120140. |Open Access | CC BY 3.0 |

*) Corresponding Authors