CMCB Extraordinary Seminar: Prof. Wolfram Goessling, Harvard Medical School, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Massachusetts

Host: Nikolay Ninov (CRTD)

Title: "Regulation of Liver Development and Regeneration"

Wolfram Goessling, MD, PhD is the Robert H. Ebert Professor of Medicine at Harvard Medical School. He is an oncologist and gastroenterologist who treats patients with chronic liver disease and liver cancer. In his laboratory, Dr. Goessling seeks to identify the molecular signals that regulate liver development, regeneration and cancer formation using zebrafish and other model systems. He received his MD and doctorate from the University of Witten/Herdecke in Germany. He trained in Internal Medicine at Brigham and Women's Hospital, served as Chief Medical Resident, and completed fellowship training in Hematology/Oncology at the combined Dana-Farber/Partners program and in Gastroenterology at the Massachusetts General Hospital. Dr. Goessling is the HMS Director of the Harvard-MIT Division of Health Sciences and Technology and Chief of the Gastroenterology Division at the Massachusetts General Hospital, where he holds the Jules L. Dienstag, MD and Betty and Newell Hale Endowed Chair in Gastroenterology.

Abstract:

In our laboratory, we use zebrafish in conjunction with murine and organoid models to investigate the regulation of endodermal progenitor cell specification, organ differentiation and regenerative and malignant growth. Our prior work has shown that we can translate our findings from the fish tank to the bedside, as clinical trials were developed based on our findings. Based on the results of chemical genetic screens, we have focused on the impact of nuclear hormone and G protein-coupled receptor signaling. More recently, we have defined the impact of metabolic and inflammatory signaling on development, regeneration and cancer formation. We utilize high-resolution spinning disc confocal imaging, single cell RNA-sequencing and organoid techniques to define the pathway and cellular determinants of organ growth. The work in our laboratory is directly relevant for developing new treatment options for patients with chronic liver disease and liver cancer.

http://goesslinglab.org/index.html

Selected recent publications:

Wrighton, P.J.,Shwartz, A., Heo, J., Quenzer, E.D., LaBella, K.A., Harper, J.W., Goessling, W., 2021. Quantitative intravital imaging in zebrafish reveals in vivo dynamics of physiological-stress-induced mitophagy. Journal of Cell Science 134, jcs256255.

Chaturantabut, S., Shwartz, A., Garnaas, M.K., Labella, K., Chia-Cheng, L., Carroll, K.J., Cutting, C.C., Budrow, N., Palaria, A., Gorelick, D.A., Tremblay, K.D., North, T.E., Goessling, W., 2020. Estrogen Acts Through Estrogen Receptor 2b to Regulate Hepatobiliary Fate During Vertebrate Development. Hepatology 72, 1786-1799

Walesky, C.M., Kolb, K.E., Winston, C.L., Henderson, J., Kruft, B., Fleming, I., Ko, S., Monga, S.P., Mueller, F., Apte, U., Shalek, A.K., Goessling, W., 2020. Functional compensation precedes recovery of tissue mass following acute liver injury. Nature Communications 11, 5785.

Weeks, O., Bosse, G.D., Oderberg, I.M., Akle, S. Houvras., Y., Wrighton, P.J., LaBella, K., Iverson, I., Tavakoli, S., Adatto, I., Shwartz, A., Kloosterman, D.,Tsomides, A., Charness, M.E., Peterson, R.T., Steinhauser, M.L., Fazeli, P.K., Goessling, W., 2020. Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood. Journal of Clinical Investigation 130, 2252-2269.

Cox, A.G., Tsomides, A., Yimlamai, D., Hwang, K.L., Miesfeld, J., Galli, G.G., Fowl, B.H., Fort, M., Ma, K.Y., Sullivan, M.R., Hosios, A.M., Snay, E., Yuan, M., Brown, K.K., Lien, E.C., Chhangawala, S., Steinhauser, M.L., Asara, J.M., Houvras, Y., Link, B., Vander Heiden, M.G., Camargo, F.D., Goessling, W., 2018. Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. The EMBO Journal 37, e100294.

Everybody is very welcome.