Publikationen
bioRxiv
Cudak N, López-Delgado AC, Rost F, Kurth T, Lesche M, Reinhardt S, Dahl A, Rulands S, Knopf F. Compartmentalization and synergy of osteoblasts drive bone formation in the regenerating fin. bioRxiv 2023.06.04.543617. https://doi.org/10.1101/2023.06.04.543617
Reinhardt R, Coen L, Rivandi M, Franken A, Setyono ESA, Lindenberg T, Eberhardt J, Fehm T, Niederacher D, Knopf F, Neubauer H. DanioCTC: Injection of circulating tumor cells from metastatic breast cancer patients in zebrafish xenografts for analysis of metastasis. bioRxiv 2023.06.05.543673. https://doi.org/10.1101/2023.06.05.543673
Murali Shankar N, Ortiz Montero P, Kurzyukova A, Rackwitz W, Künzel SR, Wels WS, Tonn T, Knopf F, Eitler J. Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer. bioRxiv 2023.07.11.548344. https://doi.org/10.1101/2023.07.11.548344
Selected publications
2023
Fleischhauer L, López-Delgado AC, Geurtzen K, Knopf F. Glucocorticoid effects in the regenerating fin reflect tissue homeostasis disturbances in zebrafish by affecting Wnt signaling. Frontiers in Endocrinology. 2023 May 29;14:1122351. https://doi.org/10.3389/fendo.2023.1122351
Cudak N, López-Delgado AC, Keil S, Knopf F. Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene Expr Patterns. 2023 Feb 24;48:119307. https://pubmed.ncbi.nlm.nih.gov/36841347/
2022
Geurtzen K, López-Delgado AC, Duseja A, Kurzyukova A, Knopf F. Laser-mediated osteoblast ablation triggers a pro-osteogenic inflammatory response regulated by reactive oxygen species and glucocorticoid signaling in zebrafish. Development. 2022 Apr 15;149(8):dev199803. https://pubmed.ncbi.nlm.nih.gov/35485304/
2021
Dietrich, K., Fiedler, I.A., Kurzyukova, A., López‐Delgado, A.C., McGowan, L.M., Geurtzen, K., Hammond, C.L., Busse, B. and Knopf, F. Skeletal Biology and Disease Modeling in Zebrafish. Journal of Bone and Mineral Research 36(3): 436-458. https://doi.org/10.1002/jbmr.4256
Keil, S., Gupta, M., Brand, M. and Knopf, F. Heparan sulfate proteoglycan expression in the regenerating zebrafish fin. Developmental Dynamics. 2021; 1– 13. https://doi.org/10.1002/dvdy.321
2019
Schmidt, J.R., Geurtzen, K., von Bergen, M., Schubert, K.# and Knopf, F.# Glucocorticoid treatment leads to aberrant ion and macromolecular transport in regenerating zebrafish fins. Frontiers in Endocrinology 10:674. doi: 10.3389/fendo.2019.00674, # co-corresponding authors https://pubmed.ncbi.nlm.nih.gov/31636606/
2018
Geurtzen, K. and Knopf, F. Adult zebrafish injury models to study the effects of prednisolone in regenerating bone tissue. JoVE 140, e58429, doi:10.3791/58429 https://pubmed.ncbi.nlm.nih.gov/30394396/
2017
Geurtzen, K., Vernet, A., Freidin, A., Rauner, M., Hofbauer, L.C., Schneider, J.E., Brand, M., Knopf, F. (2017). Immune suppressive and bone inhibitory effects of prednisolone in growing and regenerating zebrafish tissues. Journal of Bone and Mineral Research 32(12): 2476-2488 https://pubmed.ncbi.nlm.nih.gov/28771888/
2016
Masselink, W., Cole, N., Berger, S., Fenyes, F., Sonntag, C., Wood, A., Nguyen, P.D., Cohen, N., Knopf, F., Weidinger, G., Hall, T.E., & Currie, P.D. (2016). A somitic contribution to the apical ectodermal ridge is essential for fin formation. Nature 535 (7613): 542-546 https://pubmed.ncbi.nlm.nih.gov/27437584/
Antos, C.L., Knopf, F., and Brand, M. (2016). Regeneration of organs and appendages in zebrafish: A Window into underlying control mechanisms. In: Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester http://onlinelibrary.wiley.com/doi/abs/10.1002/9780470015902.a0022101.pub2
2014
Geurtzen, K.*, Knopf, F*., Wehner, D. Huitema, L.F., Schulte-Merker, S. and Weidinger, G. (2014). Mature osteoblasts dedifferentiate in response to traumatic bone injury in the zebrafish fin and skull. Development 141: 2225-2234. * equal contribution https://dev.biologists.org/content/141/11/2225.abstract
2011
Knopf, F., Hammond, C., Chekuru, A., Kurth, T., Hans, S., Weber, C.W., Mahatma, G., Fisher, S., Brand, M., Schulte-Merker, S., and Weidinger, G. (2011). Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Developmental Cell 20:713-724 https://pubmed.ncbi.nlm.nih.gov/21571227/
2010
Knopf, F.*, Schnabel, K.*, Haase, C., Pfeifer, K., Anastassiadis, K., and Weidinger, G. (2010). Dually inducible TetON systems for tissue-specific conditional gene expression in zebrafish. Proceedings of the National Academy of Sciences 107 (46):19933-8. * equal contribution https://pubmed.ncbi.nlm.nih.gov/21041642/