Publikationen

Selected publications

2024

López-Delgado AC, Knopf F. Two-Photon Laser-Mediated Ablation of Osteoblasts in Developing Zebrafish Larvae. JoVE Vis Exp. 2024 Sep 6;(211). https://doi.org/10.3791/67279

Gupta M, Kurth T, Heinemann F, Schwille P, Keil S, Knopf F, Brand M. Fine-tuning of Fgf8 morphogen gradient by heparan sulfate proteoglycans in the extracellular matrix. Biophysical Journal. 2024 Dec 11:S0006-3495(24)04070-0. In Press. https://doi.org/10.1016/j.bpj.2024.12.009

Gorodetska I, Offermann A, Püschel J, Lukiyanchuk V, Gaete D, Kurzyukova A, Freytag V, Haider MT, Fjeldbo CS, Di Gaetano S, Schwarz FM, Patil S, Borkowetz A, Erb HHH, Baniahmad A, Mircetic J, Lyng H, Löck S, Linge A, Lange T, Knopf F, Wielockx B, Krause M, Perner S, Dubrovska A. ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription. Theranostics. 2024 Jan 1;14(2):714-737. https://doi.org/10.7150/thno.88057

Cudak N, López-Delgado AC, Rost F, Kurth T, Lesche M, Reinhardt S, Dahl A, Rulands S, Knopf F. Compartmentalization and synergy of osteoblasts drive bone formation in the regenerating fin. iScience. 2024 Jan 8;27(2):108841. https://doi.org/10.1016/j.isci.2024.108841

2023

Reinhardt F, Coen L, Rivandi M, Franken A, Setyono ESA, Lindenberg T, Eberhardt J, Fehm T, Niederacher D, Knopf F, Neubauer H. DanioCTC: Analysis of Circulating Tumor Cells from Metastatic Breast Cancer Patients in Zebrafish Xenografts. Cancers (Basel). 2023 Nov 14;15(22):5411. https://doi.org/10.3390/cancers15225411

Murali Shankar N, Ortiz-Montero P, Kurzyukova A, Rackwitz W, Künzel SR, Wels WS, Tonn T, Knopf F, Eitler J. Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer. Frontiers in Immunology. 2023 Oct 11;14:1254821. https://doi.org/10.3389/fimmu.2023.1254821

Fleischhauer L, López-Delgado AC, Geurtzen K, Knopf F. Glucocorticoid effects in the regenerating fin reflect tissue homeostasis disturbances in zebrafish by affecting Wnt signaling. Frontiers in Endocrinology. 2023 May 29;14:1122351. https://doi.org/10.3389/fendo.2023.1122351

Cudak N, López-Delgado AC, Keil S, Knopf F. Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene Expr Patterns. 2023 Feb 24;48:119307. https://doi.org/10.1016/j.gep.2023.119307

2022

Geurtzen K, López-Delgado AC, Duseja A, Kurzyukova A, Knopf F. Laser-mediated osteoblast ablation triggers a pro-osteogenic inflammatory response regulated by reactive oxygen species and glucocorticoid signaling in zebrafish. Development. 2022 Apr 15;149(8):dev199803. https://doi.org/10.1242/dev.199803

2021

Dietrich, K., Fiedler, I.A., Kurzyukova, A., López‐Delgado, A.C., McGowan, L.M., Geurtzen, K., Hammond, C.L., Busse, B. and Knopf, F. Skeletal Biology and Disease Modeling in Zebrafish. Journal of Bone and Mineral Research 36(3): 436-458. https://doi.org/10.1002/jbmr.4256

Keil, S., Gupta, M., Brand, M. and Knopf, F. Heparan sulfate proteoglycan expression in the regenerating zebrafish fin. Developmental Dynamics. 2021; 1– 13. https://doi.org/10.1002/dvdy.321

2019

Schmidt JR, Geurtzen K, von Bergen M, Schubert K, Knopf F. Glucocorticoid treatment leads to aberrant ion and macromolecular transport in regenerating zebrafish fins. Frontiers in Endocrinology 2019 Oct 4;10:674. https://doi.org/10.3389/fendo.2019.00674

2018

Geurtzen, K. and Knopf, F. Adult zebrafish injury models to study the effects of prednisolone in regenerating bone tissue. JoVE 140, e58429, doi:10.3791/58429. https://doi.org/10.3791/58429

2017

Geurtzen, K., Vernet, A., Freidin, A., Rauner, M., Hofbauer, L.C., Schneider, J.E., Brand, M., Knopf, F. (2017). Immune suppressive and bone inhibitory effects of prednisolone in growing and regenerating zebrafish tissues. Journal of Bone and Mineral Research 32(12): 2476-2488 https://pubmed.ncbi.nlm.nih.gov/28771888/

2016

Masselink, W., Cole, N., Berger, S., Fenyes, F., Sonntag, C., Wood, A., Nguyen, P.D., Cohen, N., Knopf, F., Weidinger, G., Hall, T.E., & Currie, P.D. (2016). A somitic contribution to the apical ectodermal ridge is essential for fin formation. Nature 535 (7613): 542-546 https://pubmed.ncbi.nlm.nih.gov/27437584/

Antos, C.L., Knopf, F., and Brand, M. (2016). Regeneration of organs and appendages in zebrafish: A Window into underlying control mechanisms. In: Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester http://onlinelibrary.wiley.com/doi/abs/10.1002/9780470015902.a0022101.pub2

2014

Geurtzen, K.*, Knopf, F*., Wehner, D. Huitema, L.F., Schulte-Merker, S. and Weidinger, G. (2014). Mature osteoblasts dedifferentiate in response to traumatic bone injury in the zebrafish fin and skull. Development 141: 2225-2234. * equal contribution https://dev.biologists.org/content/141/11/2225.abstract

2011

Knopf, F., Hammond, C., Chekuru, A., Kurth, T., Hans, S., Weber, C.W., Mahatma, G., Fisher, S., Brand, M., Schulte-Merker, S., and Weidinger, G. (2011). Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Developmental Cell 20:713-724 https://pubmed.ncbi.nlm.nih.gov/21571227/

2010

Knopf, F.*, Schnabel, K.*, Haase, C., Pfeifer, K., Anastassiadis, K., and Weidinger, G. (2010). Dually inducible TetON systems for tissue-specific conditional gene expression in zebrafish. Proceedings of the National Academy of Sciences 107 (46):19933-8. * equal contribution https://pubmed.ncbi.nlm.nih.gov/21041642/