Publikationen
2021
Singh, S.P*., Chawla, P*., Hnatiuk, A., Kamel, M., Silva, L.D., Spanjard, B., Eski, S.E., Janjuha, S., Olivares, P., Kayisoglu, O.,… Junker J.P. Ninov N. (2021). A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ cells to diabetes recovery in zebrafish. In press (2021) https://doi.org/10.1101/2021.06.24.449704.
2020
Singh SP, Ninov N. Multicolor Labeling and Tracing of Pancreatic Beta-Cell Proliferation in Zebrafish. Methods Mol Biol., (2020); 2128:159-179. doi: 10.1007/978-1-0716-0385-7_12.
Chawla, P. ; Delgadillo Silva, L.F. ; Ninov, N. Insights on β-cell regeneration from the zebrafish shoal: From generation of cells to functional integration. Curr. Opin. Physiol. 14, 27-34 (2020)
2019
Salem V*., Delgadillo L*, Suba K., Georgiadou1 E., Mousavy NG., Akhtar N., Martin-Alonso A., Gaboriau D., Rothery S., Stylianides T., Carrat G., Pullen T., Pal Singh T., Hodson D., Leclerc I., Shapiro J., Marchetti P., Linford B.,, Distaso W., Ninov N** and Rutter GA**. Leader β cells coordinate Ca2+ dynamics across pancreatic islets in vivo. Nature Metabolism (2019) 1, 615–629 *joint first authors; ** co-corresponding authors
Delgadillo L., Tsakmaki A., Akhtar N., Franklin Z., Konantz J., Bewick GA., and Ninov N. Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection. Disease Models & Mechanisms (2019) 12, doi:10.1242/dmm.036004
2018
Janjuha S*., Singh SP*., Tsakmaki A., Gharavy NM., Murawala P., Konantz J., Birke S., Hodson D., Rutter G., Bewick G., and Ninov N. Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish. eLIFE (2018), doi: 10.7554/eLife.32965
Spanjaard B.; Hu B.; Mitic N.; Olivares-Chauvet P.; Janjuha S.; Ninov N.; Junker J.P.; Simultaneous lineage tracing and cell type identification using CRISPR/Cas9 induced genetic scars. Nature Biotechnology (2018), doi: 10.1038/nbt.4124
Janjuha, S., Pal Singh, S., Ninov, N. Analysis of beta-cell function using single-cell resolution calcium imaging in zebrafish islets. J. Vis. Exp. (2018): e57851
2017
Singh SP, Janjuha S, Hartmann T, Kayısoglu O, Konantz J, Birke S, Murawala P, Alfar EA, Murata K, Eugster A, Tsuji N, Morrissey E, Brand M, and Ninov N. Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nature Communications (2017). DOI : 10.1038/s41467-017-00461-3.
Kamel, M. and Ninov, N. Catching new targets in metabolic disease with a zebrafish. Curr. Opin. Pharmacol (2017) 37, 41-50
Alfar EA, Kirova D, Konantz J, Birke S, Mansfeld J, and Ninov N. Distinct Levels of Reactive Oxygen Species Coordinate Metabolic Activity with Beta-cell Mass Plasticity. Scientific Reports, (2017) 7(1):3994. doi: 10.1038/s41598-017-03873-9.