Prof. Dr. Nikolay Ninov © Prof. Dr. Nikolay Ninov

Ninov Group

The pancreatic β-cells are the key metabolic sensors and effectors for insulin release, which is the only hormone known to lower blood glucose concentrations. Type 1 diabetes mellitus is an autoimmune disease characterized by the destruction of beta-cells in the pancreatic islets, leading to insulin deficiency and hyperglycemia. In contrast, type 2 diabetes commences with insulin resistance followed by beta cell loss and hyperglycemia. Restoring functional β-cell mass is recognized as a promising therapeutic avenue towards normalizing glycemic control in both type 1 and 2 diabetics. Thus, our research goal is to understand the molecular and cellular events required for pancreatic β-cell regeneration, and apply this knowledge towards the development of cell replacement therapies for diabetes.

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Prof. Dr. Nikolay Ninov © Prof. Dr. Nikolay Ninov

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Prof. Dr. Nikolay Ninov