260604_CMCB LSS - Prof. Stephan Sigrist, Institute of Biology, Free University of Berlin

Host: Prof. Henrik Bringmann (BIOTEC)

Title: “Sleep-dependent active zone remodeling couples synaptic architecture to neuronal excitability and resilience”

Abstract: Sleep loss and aging challenge the stability of neuronal circuits and require adaptive mechanisms that preserve brain function. Our work investigates how sleep-dependent remodeling of presynaptic active zones contributes to neuronal resilience. Using Drosophila genetics, electrophysiology, proteomics, and behavioral analysis, we identify a functional interaction between the active zone scaffold Bruchpilot and Kv1/Shaker potassium channels. Moderate active zone upscaling reshapes synaptic transmission and stabilizes neuronal excitability, while restoring resilience and memory in hyperexcitable sleepless mutants. These findings suggest that sleep-regulated remodeling of presynaptic architecture acts as a homeostatic mechanism linking synaptic organization to brain stability and healthy aging.