CMCB Extraordinary Seminar: Prof. Cristina Cebrián, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Developmental Biology, Department of Pediatrics

Host: Federico Calegari (CRTD)

Title: "The twists and turns of nephrogenesis, segment differentiation and cystic disease"

Abstract:

The mammalian kidney is wonderfully complex, both functionally and anatomically. We employ mouse models, iPSC-derived kidney organoids, molecular and cellular biology to study how this anatomical complexity arises during embryonic development, and how certain genetic diseases compromise kidney structure and function. 

5 most important publications:

1. Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney. Menon R, Otto EA, Kokoruda A, Zhou J, Zhang Z, Yoon E, Chen YC, Troyanskaya O, Spence JR, Kretzler M, Cebrián C. Development. 2018 Aug 30;145(16):dev164038. doi: 10.1242/dev.164038. PMID: 30166318 Free PMC article.

2. Ret and Etv4 Promote Directed Movements of Progenitor Cells during Renal Branching Morphogenesis. Riccio P, Cebrian C, Zong H, Hippenmeyer S, Costantini F. PLoS Biol. 2016 Feb 19;14(2):e1002382. doi: 10.1371/journal.pbio.1002382. eCollection 2016 Feb. PMID: 26894589 Free PMC article.

3. The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment. Cebrian C, Asai N, D'Agati V, Costantini F. Cell Rep. 2014 Apr 10;7(1):127-37. doi: 10.1016/j.celrep.2014.02.033. Epub 2014 Mar 20. PMID: 24656820 Free PMC article.

4. Kidney development in the absence of Gdnf and Spry1 requires Fgf10. Michos O, Cebrian C, Hyink D, Grieshammer U, Williams L, D'Agati V, Licht JD, Martin GR, Costantini F. PLoS Genet. 2010 Jan 15;6(1):e1000809. doi: 10.1371/journal.pgen.1000809. PMID: 20084103 Free PMC article.

5. Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Lu BC, Cebrian C, Chi X, Kuure S, Kuo R, Bates CM, Arber S, Hassell J, MacNeil L, Hoshi M, Jain S, Asai N, Takahashi M, Schmidt-Ott KM, Barasch J, D'Agati V, Costantini F. Nat Genet. 2009 Dec;41(12):1295-302. doi: 10.1038/ng.476. Epub 2009 Nov 8. PMID: 19898483 Free PMC article.

Everybody is very welcome.