Publications
2023
Carido M, Völkner M, Steinheuer LM, Wagner F, Kurth T, Dumler N, Ulusoy S, Wieneke S, Norniella AV, Golfieri C, Khattak S, Schönfelder B, Scamozzi M, Zoschke K, Canzler S, Hackermüller J, Ader M, Karl MO (2023) Reliability of human retina organoid generation from hiPSC-derived neuroepithelial cysts. Front. Cell. Neurosci. 17, 1166641. https://doi.org/10.3389/fncel.2023.1166641
Bilekova S, Garcia-Colomer B, Cebrian-Serrano A, Schirge S, Krey K, Sterr M, Kurth T, Hauck SM, Lickert H (2023) Inceptor facilitates acrosomal vesicle formation in spermatids and is required for male fertility. Front. Cell Dev. Biol. 11, 1240039 https://doi.org/10.3389/fcell.2023.1240039
Stepien BK, Pawolski V, Wagner MC, Kurth T, Schmidt MHH, Epperlein HH (2023) The role of posterior neural plate-derived presomitic mesoderm (PSM) in trunk and tail muscle formation and axis elongation. Cells 12(9), 1313, https://doi.org/10.3390/cells12091313
Völkner M, Wagner F, Kurth T, Sykes AM, Del Toro Runzer C, Ebner LJA, Kavak C, Alexaki VI, Cimalla P, Mehner M, Koch E, Karl MO (2023) Modeling inducible neuropathologies of the retina with differential phenotypes in organoids. Front. Cell. Neurosci. 17, 1106287, https://doi.org/10.3389/fncel.2023.1106287
Schuez M, Kurth T, Currie JD, Sandoval-Guzmán T (2023) Embryonic tissue and blastema transplantations. Methods Mol. Biol. 2562, 235-247, https://10.1007/978-1-0716-2659-7
Weise K, Kurth T, Schmidt A, Winkelmann C, Becker J, Kretschmar S, Berendonk TU, Jungmann D (2023) Impact of weathered multi-walled carbon nanotubes on the epithelial cells of the intestinal tract in the freshwater grazers Lymnaea stagnalis and Rhithrogena semicolorata. Environmental Science and Pollution Research 30, 407-419 https://doi.org/10.1007/s11356-022-22225-3
2022
Völkner M, Wagner F, Steinheuer LM, Carido M, Kurth T, Yazbeck A, Schor J, Wieneke S, Ebner L, Del Toro Runzer C, Taborsky D, Zoschke K, Vogt M, Canzler S, Hermann A, Khattak S, Hackermüller J, Karl MO (2022) HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids. Nat. Commun. 13, 6183 https://doi.org/10.1038/s41467-022-33848-y
Gasparini SJ, Tessmer K, Reh M, Wieneke S, Carido M, Völkner M, Borsch O, Swiersy A, Zuzic M, Goureau O, Kurth T, Busskamp V, Zeck G, Karl MO, Ader M (2022) Transplanted human cones incorporate and function in a murine cone degeneration model. J. Clin. Invest. 132, e154619 https://doi.org/10.1172/JCI154619
Donau J, Luo H, Virta I, Skupin A, Pushina M, Loeffler J, Haertel FV, Das A, Kurth T, Gerlach M, Lindemann D, Reinach PS, Mergler S, Valtink M (2022) TRPV4 stimulation level regulates Ca2+-dependent control of human corneal endothelial cell vitality and survival. Membranes 12, 281 https://doi.org/10.3390/membranes12030281
Dohnke S, Moehser S, Surnov A, Kurth T, Jessberger R, Kretschmer K, Garbe AI (2022) Role of dynamic actin cytoskeleton remodeling in Foxp3+ regulatory T cell development and function: Implications for osteoclastogenesis, Front. Immunol. 13, 836646 https://doi.org/10.3389/fimmu.2022.836646
Xu Y, Gaillez MP, Zheng K, Voigt D, Cui M, Kurth T, Xiao L, Rothe R, Hauser S, Wieduwild R, Lin W, Bornhäuser M, Pietzsch J, Boccaccini AR, Zhang Y (2022) A self-assembled matrix system for bioengineering in different dimensions, scales, and geometries. Small, 2104758 https://doi.org/10.1002/smll.202104758
Weise K, Kurth T, Politowski I, Winkelmann C, Schäffer A, Kretschmar S, Berendonk TU, Jungmann D (2021) A workflow to investigate the impacts of weathered multi-walled carbon nanotubes to the mudsnail Lymnaea stagnalis. Environmental Science and Pollution Research 29, 26706-26725 doi.org/10.1007/s11356-021-17691-0
Furesi G, de Jesus Domingues AM, Alexopoulou D, Dahl A, Hackl M, Schmidt JR, Kalkhof S, Kurth T, Taipaleenmäki H, Conrad S, Hofbauer C, Rauner M, Hofbauer LC (2022) Exosomal miRNAs from prostate cancer impair osteoblast function in mice. Int. J. Mol. Sci. 23, 1285 https://doi.org/10.3390/ijms23031285
Singh SP, Chawla P, Hnatiuk A, Kamel M, Delgadillo Silva L, Spanjard B, Eski SE, Janjuha S, Olivares P, Kayisoglu O, Rost F, Bläsche J, Kränkel A, Petzold A, Kurth T, Reinhardt S, Junker JP, Ninov N (2022) A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish. Development 149, dev199853 https://doi.org/10.1242/dev.199853
Kanczkowski W, Evert K, Stadtmüller M, Haberecker M, Laks L, Chen LS, Frontzek K, Pablik J, Hantel C, Beuschlein F, Kurth T, Gruber S, Aguzzi A, Varga Z, Bornstein SR (2021) COVID-19 targets human adrenal glands. Lancet Diabetol. Endocrinol. 10, 13-16 doi.org/10.1016/S2213-8587(21)00291-6
2021
Rhode P, Mehdorn M, Lyros O, Kahlert C, Kurth T, Venus T, Schierle K, Estrela-Lopis I, Jansen-Winkeln B, Lordick F, Gockel I, Thieme R (2021) Characterization of total RNA, CD44, FASN, and PTEN mRNAs from extracellular vesicles as biomarkers in gastric cancer patients. Cancers 13, 5975 doi.org/10.3390/cancers13235975
Strigli A, Gopalakrishnan S, Zeissig Y, Basic M, Wang J, Schwerd T, Doms S, Peuker K, Hartwig J, Harder J, Hönscheid P, Arnold P, Kurth T, Rost F, Petersen BS, Forster M, Franke A, Kelsen JR, Rohlfs M, Klein C, Muise AM, Warner N, Nambu R, Mayerle J, Török HP, Linkermann A, Muders MH, Baretton GB, Hampe J, Aust DE, Baines JF, Bleich A, Zeissig S (2021) Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation. Science Immunol. 6, eabf7473 doi.org/10.1126/sciimmunol.abf7473
Kemter E, Müller A, Neukam M, Ivanova A, Klymiuk N, Renner S, Yang K, Broichhagen J, Kurome M, Zakhartchenko V, Kessler B, Knoch KP, Bickle M, Ludwig B, Johnsson K, Lickert H, Kurth T, Wolf E, Solimena M (2021) Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs. PNAS 118 (37), e2107665118, doi.org10.1073/pnas.2107665118
Xu Y, Rothe R, Voigt D, Hauser S, Cui M, Miyagawa T, Patino Gaillez M, Kurth T, Bornhäuser M, Pietzsch J, Zhang Y (2021) Convergent synthesis of diversified reversible network leads to liquid metal-containing conductive hydrogel adhesives. Nat. Commun. 12, 2407 doi.org/10.1038/s41467-021-22675-2
Völkner M, Kurth T, Schor J, Ebner LJA, Bardtke L, Kavak C, Hackermüller J, Karl MO (2021) Mouse retinal organoid growth and maintenance in longer-term culture. Front. Cell Dev. Biol. 9, 645704 doi.org/10.3389/fcell.2021.645704
Müller A, Schmidt D, Xu CS, Pang S, D'Costa J, Kretschmar S, Münster C, Kurth T, Jug F, Weigert M, Hess H, Solimena M (2021) 3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse beta cells. J Cell Biol (2021) 220 (2): e202010039, https://doi.org/10.1083/jcb.202010039
Roscito JG, Subramanian K, Naumann R, Sarov M, Shevchenko A, Bogdanova A, Kurth T, Foerster L, Kreysing M, Hiller M (2021) Recapitulating evolutionary divergence in a single cis-regulatory element is sufficient to cause expression changes of the lens gene Tdrd7. Mol. Biol. Evol. 38(2), 380-392. 10.1093/molbev/msaa212
Južnic L, Peuker K, Strigli A, Brosch M, Herrmann A, Häsler R, Koch M, Matthiesen L, Zeissig Y, Löscher BS, Nuber A, Schotta G, Neumeister V, Chavakis T, Kurth T, Lesche M, Dahl A, von Mässenhausen A, Linkermann A, Schreiber S, Aden K, Rosenstiel P, Franke A, Hampe J, Zeissig S (2021) SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation. Gut, 70, 485-498. doi: 10.1136/gutjnl-2020-321339
2020
Tsata V, Kroehne V, Wehner D, Fabian Rost F, Lange C, Hoppe C, Kurth T, Reinhardt S, Petzold A, Dahl A, Löffler M, Reimer MM, Brand M (2020) Reactive oligodendrocyte progenitor cells (re-) myelinate the regenerating zebrafish spinal cord. Development 147, dev193946, doi.org/10.1242/dev.193946
Eberle D, Fodelianaki G, Kurth T, Jagielska A, Möllmert S, Ulbricht E, Wagner K, Taubenberger AV, Träber N, Escolano JC, Van Vliet KJ, Guck J (2020) Acquired demyelination but not genetic developmental defects in myelination leads to brain tissue stiffness changes. Brain Multiphysics 1, 100019 doi.org/10.1016/j.brain.2020.100019
Corbeil D, Santos MF, Karbanová J, Kurth T, Rappa G, Lorico A (2020) Uptake and fate of extracellular membrane vesicles: nucleoplasmic reticulum-associated late endosomes as a new gate of intercellular communication. Cells 9(9), E1931 10.3390/cells9091931
Roscito JG, Subramanian K, Naumann R, Sarov M, Shevchenko A, Bogdanova A, Kurth T, Foerster L, Kreysing M, Hiller M (2020) Recapitulating evolutionary divergence in a single cis-regulatory element is sufficient to cause expression changes of the lens gene Tdrd7. Mol. Biol. Evol., in press 10.1093/molbev/msaa212
Wiedmer S, Kurth T, Buder U, Bleischwitz S, Entzeroth R, Kurth M (2020) Correlative light and electron microscopy of wall formation in Eimeria nieschulzi. Parasitol. Res. 119, 2667-2678 https://doi.org/10.1007/s00436-020-06765-6
Južnic L, Peuker K, Strigli A, Brosch M, Herrmann A, Häsler R, Koch M, Matthiesen L, Zeissig Y, Löscher BS, Nuber A, Schotta G, Neumeister V, Chavakis T, Kurth T, Lesche M, Dahl A, von Mässenhausen A, Linkermann A, Schreiber S, Aden K, Rosenstiel P, Franke A, Hampe J, Zeissig S (2020) SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation. Gut, in press doi.org/10.1136/gutjnl-2020-321339
Almedawar S, Vafia K, Schreiter S, Kurth T, Ader M, Karl MO, Tsang SH, Tanaka EM (2020) MERTK-dependent ensheathment of photoreceptor outer segments by human pluripotent stem cells-derived retinal pigment epithelium. Stem Cell Rep. 14, 374-389 https://doi.org/10.1016/j.stemcr.2020.02.004
Möllmert S, Kharlamova MA, Hoche T, Taubenberger AV, Abuhattum S, Kuscha V, Kurth T, Brand M, Guck J (2020) Zebrafish spinal cord repair is accompanied by transient tissue stiffening. Biophys. J. 118 (2): 448-463 https://doi.org/10.1016/j.bpj.2019.10.044
2019
Binger KJ, Neukam M, Tattikota S, Qadri F, Puchkov D, Willmes D, Wurmsee S, Geisberger SY, Dechend R, Raile K, Kurth T, Nguyen G, Poy M, Solimena M, Müller D, Birkenfeld A (2019) Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic ß-cells. PNAS, 160 (40), 19983-19988 https://doi.org/10.1073/pnas.1903678116
Taubenberger AV, Girardo S, Träber N, Fischer-Friedrich E, Kräter M, Wagner K, Kurth T, Richter I, Haller B, Binner M, Hahn D, Freudenberg U, Werner C, Guck J (2019) 3D microenvironment stiffness regulates tumor spheroid growth and mechanics via p21 and ROCK. Adv. Biosys. 1900128 doi: 10.1002/adbi.201900128
Völkner M, Kurth T, Karl MO (2019) The Mouse Retinal Organoid Trisection Recipe: Efficient Generation of 3D Retinal Tissue from Mouse Embryonic Stem Cells. Methods Mol Biol. 1834, 119-141 https://doi.org/10.1007/978-1-4939-8669-9_9
Kurth T, Kretschmar S, Buttstedt A (2019) Royal jelly in focus. Insectes Sociaux, 66, 81-89 doi.org/10.1007/s00040-018-0662-3
2018
Santos MF, Rappa G, Karbanova J, Kurth T, Corbeil D, Lorico A (2018) VAMP-associated protein-A and oxysterol-binding protein-related protein 3 promote the entry of late endosomes into the nucleoplasmic reticulum. J. Biol. Chem. 293(36), 13834-13848 doi:10.1074/jbc.RA118.003725
Papadimitriou C, Celikkaya H, Cosacak MI, Mashkaryan V, Bray L, Bhattarai P, Brandt K, Hollak H, Chen X, He S, Antos CL, Lin W, Thomas AK, Dahl A, Kurth T, Friedrichs J, Zhang Y, Freudenberg U, Werner C, Kizil C (2018). 3D culture method for Alzheimer’s disease modeling reveals interleukin-4 rescues Aß42-induced loss of human neural stem cell plasticity. Dev. Cell 46, 85-110 doi.org/10.1016/j.devcel.2018.06.005
Xu Y, Yang X, Thomas AK, Patsis PA, Kurth T, Kraeter M, Eckert K, Bornhaeuser M, Zhang Y (2018). Non-covalently assembled electroconductive hydrogel. ACS Appl. Mater. Interfaces 10, 14418-14425 doi.org/10.1021/acsami.8b01029
Kretschmar S, Kurth T (2018) Need for Speed. Tips & Tricks for rapid preparation of tissue samples for TEM. Imaging & Microscopy 20, 35-37
2017
Goncalves DPN, Rodriguez RD, Kurth T, Bray LJ, Binner M, Jungnickel C, Gür FN, Poser SW, Schmidt TL, Zahn DRT, Androutsellis-Theotokis A, Schlierf M, Werner C (2017) Enhanced targeting of invasive glioblastoma cells by peptide-functionalized gold nanorods in hydrogel-based 3D cultures. Acta Biomater. 58, 12-25 doi.org/10.1016/j.actbio.2017.05.054
Papanikos F, Daniel K, Goercharn-Ramlal A, Fei JF, Kurth T, Wojtasz L, Dereli I, Fu J, Penninger J, Habermann B, Surani A, Stewart AF, Toth A (2017) The enigmatic meiotic dense body and its newly discovered component, SCML1, are dispensible for fertility and gametogenesis in mice. Chromosoma 126, 399-415 https://doi.org/10.1007/s00412-016-0598-1
Müller A, Neukam M, Ivanova A, Sönmez A, Münster C, Kretschmar S, Kalaizidis Y, Kurth T, Verbavatz JM, Solimena M (2017) A global approach for quantitative super resolution and electron microscopy on cryo and epoxy sections using self-labeling protein tags. Sci. Rep. 7, 23 doi.org/10.1038/s41598-017-00033-x
Taniguchi1, Kurth T1,*, Weiche S, Reichelt S, Tazaki A, Perike S, Kappert V, Epperlein HHE (2017) The posterior neural plate in axolotl gives rise to neural tube or turns anteriorly to form somites of the tail and posterior trunk. Dev. Biol. 422, 155-170 (1equal contribution, *corresponding author) doi.org/10.1016/j.ydbio.2016.12.023
2016
Bhattarai P, Thomas AK, Cosacak MI, Papadimitriou C, Mashkaryan V, Froc C, Reinhardt S, Kurth T, Dahl A, Zhang Y, Kizil C (2016) IL4/STAT6 signaling activates neural stem cell proliferation and neurogenesis upon amyloid-ß42 aggregation in adult zebrafish brain. Cell Reports 17, 941-948 doi.org/10.1016/j.celrep.2016.09.075
Borg DJ, Welzel PB, Grimmer M, Friedrichs J, Weigelt M, Wilhelm C, Prewitz M, Stißel A, Hommel A, Kurth T, Freudenberg U, Bonifacio E, Werner C (2016) Macroporous biohybrid cryogels for co-housing pancreatic islets with mesenchymal stromal cells. Acta Biomaterialia 44, 178-187 doi.org/10.1016/j.actbio.2016.08.007
Wolf C, Rapp A, Berndt N, Staroske W, Schuster M, Dobrick-Mattheuer M, Kretschmer S, König N, Kurth T, Wieczorek D, Kast K, Cardoso MC, Günther C, Lee-Kirsch MA (2016) RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA. Nat. Commun. 7, 11752 doi.org/10.1038/ncomms11752
2015
Kurgonaite K, Gandhi H, Kurth T, Pautot S, Schwille P, Weidemann T, Bökel C (2015) Essential role of endocytosis for interleukin-4-receptor-mediated JAK/STAT signalling. J. Cell Sci. 128, 3781-3795 doi.org/10.1242/jcs.170969
Kurth T, Kretschmar S (2015) CLEM in the classroom: protocols for undergraduate courses. Imaging & Microscopy 17 (3), 25-27
Taniguchi Y, Kurth T, Meulemans-Medeiros D, Tazaki A, Ramm R, Epperlein HH (2015) Mesodermal origin of median fin mesenchyme and tail muscle in amphibian larvae. Sci. Rep. 5, 11428 doi.org/10.1038/srep11428
Sinningen K, Albus E, Thiele S, Grossklaus S, Kurth T, Udey MC Chaakis T, Hofbauer LC, Rauner M (2015) Loss of milk fat globule-epidermal growth factor 8 in mice leads to low bone mass and accelerates ovariectomy-associated bone loss by increasing osteoclastogenesis. Bone 76, 107-114 doi.org/10.1016/j.bone.2015.04.003
Santos-Ferreira T, Postel K, Stutzki H, Kurth T, Zeck G, Ader M (2015) Daylight vision repair by cell transplantation. Stem Cells 33, 79-90 doi.org/10.1002/stem.1824
2014
Bailly X, Laguerre L, Correc G, Dupont S, Kurth T, Pfannkuchen A, Entzeroth R, Probert I, Vinogradov S, Lechauve C, Garet-Delmas ML, Reichert H, Hartenstein V (2014) The chimerical and multifaceted marine acoel Symsagittifera roscoffensis: from photosymbiosis to brain regeneration. Front. Microbiol. 5, 498 doi.org/10.3389/fmicb.2014.00498
Zarzosa A, Grassme K, Tanaka E, Taniguchi Y, Bramke S, Kurth T, Epperlein HH (2014) Axolotls with an under- or oversupply of neural crest can regulate the sizes of their dorsal root ganglia to normal levels. Dev. Biol. 394, 65-82 doi.org/10.1016/j.ydbio.2014.08.001
Carido M, Zhu Y, Postel K, Benkner B, Cimalla P, Karl MO, Kurth T, Paquet-Durand, Koch E, Münch TA, Tanaka EM, Ader M (2014) Characterization of a mouse model with complete RPE loss and its use for RPE cell transplantation. Invest. Ophthalmol.Vis. Sci. 55, 5431-5444 doi.org/10.1167/iovs.14-14325
2013
Kurth T, Kretschmar S, Eberle D, Ader M (2013) CLEM on ultrathin sections. Imaging & Microscopy 15 (3), 16-18
Ivanova A, Kalaidzidis Y, Dirkx R, Sarov M, Gerlach M, Schroth-Diez B, Müller A, Liu Y Andree C, Mulligan B, Münster C, Kurth T, Bickle M, Speier S, Anastassiadis K, Solimena M (2013) Age-dependent labeling and imaging of insulin secretory granules. Diabetes 62, 3687-3696 doi.org/10.2337/db12-1819
Zhu Y, Carido M, Meinhardt A, Kurth T, Karl MO, Ader M, Tanaka E (2013) Three-dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium. PLoS ONE 8, e54552 doi.org/10.1371/journal.pone.0054552
2012
Eberle D, Kurth T, Santos-Ferreira T, Wilson J, Corbeil D, Ader M (2012) Outer segment formation of transplanted photoreceptor cells. PLoS ONE 7, e46305 doi.org/10.1371/journal.pone.0046305
Seemann E, Kurth T, Entzeroth R (2012) Insight into the ultrastructural organisation of sporulated oocysts of Eimeria nieschulzi (Coccidia, Apicomplexa). Parasitol. Res. 111, 2143-2147 doi.org/10.1007/s00436-012-3066-8
Schiller M, Massalski C, Kurth T, Steinebrunner I (2012) The Arabidopsis apyrase AtAPY1 is localized in the Golgi instead of the extracellular space. BMC Plant Biol. 12, 123 doi.org/10.1186/1471-2229-12-123
Fabig G, Kretschmar S, Weiche S, Eberle D, Ader M, Kurth T (2012) Labeling of ultrathin resin sections for correlative light and electron microscopy. Methods Cell Biol. 111, 75-93 doi.org/10.1016/B978-0-12-416026-2.00005-4
Kurth T, Weiche S, Vorkel D, Kretschmar S, Menge A (2012) Histology of plastic embedded amphibian embryos and larvae. Genesis 50, 235-250 doi.org/10.1002/dvg.20821
Kurth T, Wiedmer S, Entzeroth R (2012) Improvement of ultrastructural preservation of Eimeria oocysts by microwave-assisted chemical fixation or by high pressure freezing and freeze substitution. Protist 163, 296-305 doi.org/10.1016/j.protis.2011.06.001
Pfennig F, Kurth T, Meißner S, Standke A, Hoppe M, Zieschang F, Reitmayer C, Göbel A, Kretschmar G, Gutzeit HO. (2012) The social status of the male Nile tilapia (Oreochromis niloticus) influences testis structure and gene expression. Reproduction 143, 71-84 doi.org/10.1530/REP-11-0292
2011
Kauert DJ, Kurth T, Liedl T, Seidel R. (2011) Direct mechanical measurements reveal the material properties of 3D DNA-origami. Nano Lett. 11, 5558-5563 doi.org/10.1021/nl203503s
Wiedmer S, Stange J, Kurth T, Bleiss W, Entzeroth R, Kurth M (2011) New insights into the excystation process and oocyst morphology of rodent Eimeria species. Protist 162, 668-678 doi.org/10.1016/j.protis.2011.03.001
Knopf F, Hammond C, Chekuru A, Kurth T, Hans S, Weber CW, Mahatma G, Fisher S, Brand M, Schulte-Merker S, and Weidinger G. (2011) Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Dev. Cell 20, 713-724 doi.org/10.1016/j.devcel.2011.04.014
Schnabel K, Wu CC, Kurth T, and Weidinger G (2011) Regeneration of cryoinjury induced necrotic heart lesions in zebrafish is associated with epicardial activation and cardiomyocyte proliferation. PLoS ONE 6, e18503 doi.org/10.1371/journal.pone.0018503