Biofunctionalized Surfaces
(Status: 10/2024)
| Lecturer | PD Dr. habil. Vera Hintze & Dr. Susanne Bierbaum |
| Guest lecturers | Dr. Ute Bergmann, Dr. Poh Soo Lee, Doc.RNDr. Marie Hubálek Kalbáčová |
| Contact person | Mrs. Marita Keil |
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Scope . . |
2 SWS lecture, self-study Start: October 18, 2024, 13:00 h Location: Seminar room MBZ, ground floor |
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Examination . . . . . |
for WW students and other students MW written exam, 90 minutes; for all other students oral exam, 20 minutes Date: by arrangement no examination materials permitted Individual examination |
| Dates/timetable |
each winter semester |
| Teaching material | Biofunctionalized surfaces |
| Content of the course |
The central topic of the lecture is the processes that take place when biomaterials come into contact with biological systems. The causes, the potential biological consequences and in particular the possibilities of influencing such interface processes through surface design are discussed. The relevant principles of cell communication and cell reaction to the biochemical and physical properties of their environment are also considered. Various methods for the defined design of biomaterial surfaces are explained with special consideration of (i) the biological background, (ii) the methods for generating the surface states, (iii) the desired surface properties and (iv) the cell biological, animal experimental and clinical results. This includes
- the generation of defined morphologies by physical and chemical processes,
- physical/chemical modification of surface properties,
- inorganic coating systems and
- the field of BioSurface Engineering, i.e. the biomimetic reproduction of the native cell environment provided by the extracellular matrix (ECM).
In the latter, the possible uses of various components of the native ECM (peptides, (structural) proteins, growth factors, glycosaminoglycans, nucleic acids, aptamers) for biosurface engineering are presented and, depending on substrates and components, the advantages and disadvantages of immobilization strategies are presented in detail. This will be discussed using examples from the working group's current research.
Finally, physical influences (mechanical stimulation, electric and magnetic fields) on cellular processes up to tissue healing are discussed. Key aspects are the importance of signals for cells, their transmission and recognition by cells and the role of the type of signal.
The lecture will be held in English and is aimed in particular at students of Material Science, Biotechnology and natural sciences in specialist or Master's degree programs.
The lecture will take place in the seminar room of the Max Bergmann Center for Biomaterials, Budapester Str. 27.
Please register for the opal course Biofunctionalized surfaces!