L.Trahms: Metrology of magnetic hybrid materials for biomedical applications
Description
Biomedical applications of magnetic nanoparticles (MNP) are based on the interaction of MNP with surrounding tissue, cells or blood stream. The aim is to act on the tissue by static or alternating magnetic fields, using MNPs as local mediators or actuators. Examples for these applications are targeted heating of tumor tissue (Hyperthermia, Magnetic Thermoablation), contrast enhancement in imaging modalities (MRI, Magnetic Particle Imaging), and targeted accumulation of therapeutic agents or gene vectors (Magnetic Drug Targeting, Magnetofection).
Magnetic measurement techniques are sensitive and powerful tools that may support the development of these applications, since they are non-invasive and can be applied in-vivo without being compromised by the turbidity of the investigated media.
The project focuses on physically well-defined hybrid systems of MNP embedded in a matrix that may serve as model systems for biomedical applications. In particular, we address the physics of particle-matrix interactions in an external magnetic field during transportation and heating processes in resting and flowing media. All studies will be performed in close cooperation with medical partners.
Rabbit phantom for quantitative imaging of magnetic MNP-matrix hybrid materials.
Project Manager
Dir. u. Prof. Dr. Lutz Trahms, Physikalisch-Technische Bundesanstalt Berlin
Staff
Dietmar Eberbeck, Physikalisch-Technische Bundesanstalt Berlin
Maik Liebl, Physikalisch-Technische Bundesanstalt Berlin
Grant period
2013 -
Publications
[1] Wiekhorst, F., Steinhoff, U., Eberbeck, D., & Trahms, L. (2012). Magnetorelaxometry assisting biomedical applications of magnetic nanoparticles. Pharmaceutical Research, 29(5), 1189-1202.
[2] Wiekhorst, F., Liebl, M., Steinhoff, U., Trahms, L., Lyer, S., Dürr, S., & Alexiou, C. (2012). Magnetorelaxometry for In-Vivo Quantification of Magnetic Nanoparticle Distributions after Magnetic Drug Targeting in a Rabbit Carcinoma Model. In Magnetic Particle Imaging (pp. 301-305). Springer Berlin Heidelberg.
[3] Harms, C., Datwyler, A. L., Wiekhorst, F., Trahms, L., Lindquist, R., Schellenberger, E., ... & Farr, T. D. (2013). Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke. Journal of Cerebral Blood Flow & Metabolism, 33(5), e1-e9.
[4] Wenzel, D., Rieck, S., Vosen, S., Mykhaylyk, O., Trueck, C., Eberbeck, D., ... & Fleischmann, B. K. (2012). Identification of magnetic nanoparticles for combined positioning and lentiviral transduction of endothelial cells. Pharmaceutical research, 29(5), 1242-1254.
Contact
Physikalisch-Technische Bundesanstalt
Fachbereich 8.2
Abbestr. 2-12
10587 Berlin