Systembiotech­nology

lecture script

The lecture contains basically the following topics:

•  Stoichiometric analysis of metabolic networks (flux balance analysis, elementary flux mode analysis)
• ¹³C-based metabolic flux analysis
• Concepts for mathematical modelling of the regulation of metabolic pathways (metabolic control analysis)
• DNA engineering for the optimisation of protein expression
• Implementation and evaluation of transcriptome analyses (next generation sequencing, hierarchical clustering, functional genomics)

The lectures are accompanied by computer exercises in which the students are introduced to various programmes: 

• CellNetAnalyzer for stoichiometric analysis of metabolic networks
• 13C-Flux and OMIX for the evaluation of metabolic flux experiments
• COPASI for metabolic control analysis
• R for statistical analysis of transcriptome studies

Workload and audience

• 4 weekly lecture hours in the winter semester ( 2 h lecture and  2 h exersice)
• for interested students of bioprocess engineering and students of biological disciplines.

Lecturer

© Ritz

Name

Prof. Dr.-Ing. Thomas Walther

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