Philipp Abe
RESEARCH FIELD
Developmental neuroscience and plasticity
Dr. Philipp Abe is specialized in understanding how molecules shape neuronal circuits in the developing brain. He employs diverse mouse models and cutting-edge tools like single-cell RNA-seq and light-sheet microscopy to dissect gene expression and neuronal architecture. Beyond research, he is teaching medical students and guiding graduate research, demonstrating his passion for sharing knowledge and fostering scientific excellence.
SCIENTIFIC EXPERIENCE
| Since 2022 | Research associate at Institute of Anatomy, Medical Faculty, TU Dresden |
| 2021-2022 | Maître Assistant in the laboratory of Prof. Denis Jabaudon |
| 2020-2021 | IRP Post-doctoral fellow in the laboratory of Prof. Denis Jabaudon |
| 2017-2019 | EMBO Long-term Fellow and research assistant in the laboratory of Prof. Denis Jabaudon, Department of Basic Neurosciences, University of Geneva |
| 2011-2017 |
Scientific associate in the group of Prof. Ralf Stumm at the Institute of Pharmacology and Toxicology Jena University Hospital, Friedrich-Schiller-University Jena Scientific visit of Prof. Zoltán Molnár’s laboratory at University of Oxford, Department of Physiology, Anatomy and Genetics (06/2012) |
| 2011 | Diploma student at the Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich-Schiller-University Jena |
EDUCATION
| 2016 | Doctor rerum naturalium (PhD), Summa cum laude, Pharmacology and Toxicology, University hospital Jena, Germany |
| 2006-2011 |
Diploma in Biology, University of Jena, Germany Major subject: Genetics, Minor subjects: Neurobiology, Medical microbiology |
PUBLICATION
https://pubmed.ncbi.nlm.nih.gov/?term=Abe+Philipp%5BAuthor%5D
Preprints
PUBLICATIONS
Lo Giudice Q, Wagener RJ, Abe P, Frangeul L, Jabaudon D. Developmental emergence of first- and higher-order thalamic neuron molecular identities. bioRxiv 2024.01.22.576610; doi: https://doi.org/10.1101/2024.01.22.576610
Baumann N, Wagener RJ, Javed A, Abe P, Lopes A, Lavalley A, Fuciec D, Magrinelli E, Fièvre S, Jabaudon D. Regional Differences in Progenitor Consumption Dynamics Shape Brain Growth during Development. bioRxiv 2023.08.21.553891; doi: https://doi.org/10.1101/2023.08.21.553891
Abe P, Lavalley A, Morassut I, Klingler E, Santinha AJ, Platt RJ, Jabaudon D. Developmental molecular controls over arealization of descending cortical motor pathways. bioRxiv 2023.06.29.546438; doi: https://doi.org/10.1101/2023.06.29.546438
Venkataramanappa S, Saaber F, Abe P, Schütz D, Kumar PA, Stumm R. Cxcr4 and Ackr3 regulate allocation of caudal ganglionic eminence-derived interneurons to superficial cortical layers. Cell Reports, 2022 Aug 2;40(5):111157. doi: 10.1016/j.celrep.2022.111157. PMID: 35926459.
Venkataramanappa, S., Schütz, D., Saaber, F., Ashok Kumar, P., Abe, P., Stefan Schulz, S., Stumm, R.(2021) The microcephaly gene Donson is essential for progenitors of cortical glutamatergic and GABAergic neurons. PLOS Genetics 17(3):e1009441.doi:10.1371/journal.pgen.1009441
Saaber, F., Schütz, D., Miess, E., Abe, P., Desikan, S., Ashok Kumar, P., . . . Stumm, R. (2019). ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin. Cell Reports, 26(6), 1473-1488.e1479. doi:https://doi.org/10.1016/j.celrep.2019.01.049
Klingler, E., De la Rossa, A., Fièvre, S., Devaraju, K., Abe, P., & Jabaudon, D. (2019). A Translaminar Genetic Logic for the Circuit Identity of Intracortically Projecting Neurons. Current Biology, 29(2), 332-339.e335. doi:https://doi.org/10.1016/j.cub.2018.11.071
Abe P*, Wüst HM*, Arnold SJ, van de Pavert SA, Stumm R. (2018). CXCL12‐mediated feedback from granule neurons regulates generation and positioning of new neurons in the dentate gyrus. Glia. 66:1566–1576.
Abe, P., Molnar, Z., Tzeng, Y. S., Lai, D. M., Arnold, S. J. and Stumm, R. (2015). Intermediate Progenitors Facilitate Intracortical Progression of Thalamocortical Axons and Interneurons through CXCL12 Chemokine Signaling. J Neurosci 35, 13053-13063.
Abe, P.*, Mueller, W.*, Schutz, D., MacKay, F., Thelen, M., Zhang, P. and Stumm, R. (2014). CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons. Development 141, 1857-1863.
Bodea, G. O., Spille, J. H., Abe, P., Andersson, A. S., Acker-Palmer, A., Stumm, R., Kubitscheck, U. and Blaess, S. (2014). Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system. Development 141, 661-673.
Abe, P.*, Schultheiss, C.*, Hoffmann, F., Mueller, W., Kreuder, A. E., Schutz, D., Haege, S., Redecker, C., Keiner, S., Kannan, S. et al. (2013). CXCR4 prevents dispersion of granule neuron precursors in the adult dentate gyrus. Hippocampus 23, 1345-1358.
Memi, F., Abe, P., Cariboni, A., MacKay, F., Parnavelas, J. G. and Stumm, R. (2013). CXC chemokine receptor 7 (CXCR7) affects the migration of GnRH neurons by regulating CXCL12 availability. J Neurosci 33, 17527-17537.
* authors contributed equally