PhD Thesis Defense Dr. Sukrit Mahajan "EGFL7-driven immune evasion in malignant glioma: mechanistic insights and therapeutic implications"

The study focused on investigating tumor-intrinsic mechanisms driving immune evasion in glioblastoma, the most aggressive form of brain cancer. Dr. Sukrit Mahajan identified the angiogenic factor EGFL7 as an important regulator of the glioma immune landscape, through its interaction with immune cell receptor integrin β2 (ITGB2). This interaction promotes T cell exhaustion and skews macrophage polarization towards a pro-tumorigenic phenotype. Targeting the EGFL7–ITGB2 axis opens promising therapeutic avenues to enhance the efficacy of immune checkpoint blockade in glioblastoma.

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