Mar 04, 2026
NEW PUBLICATION: Precancerous niche remodelling dictates nascent tumour persistence
Early tumour cells remodel the surrounding stromal tissue, creating an environment that supports their survival and continued growth. Connective tissue, fibroblasts, and immune cells actively contribute to this process. © Adapted from: Skrupskelyte, G. et al., Nature (2026).
We are pleased to announce our contribution to an international study published in Nature. Together with our collaborators, we demonstrated that alterations in the tissue microenvironment can establish a “precancerous niche” that supports the survival and persistence of newly emerging tumour cells before overt cancer develops. By combining analyses of human tissue samples with advanced molecular and imaging approaches, we helped uncover the mechanisms underlying this process. Our findings provide new insights into the earliest stages of cancer development and may open new avenues for future cancer prevention and early intervention strategies.
Publication: Skrupskelyte G. et al. Precancerous niche remodelling dictates nascent tumour persistence. Nature (2026).