When the Inflammation Inhibitor Fails: New Findings on RELA Mutations

A research team led by Min Ae Lee-Kirsch and Johanna Klughammer demonstrates how certain mutations in the RELA gene lead to autoinflammation and autoimmunity: They impair the body’s own regulatory mechanisms of the NF-κB signaling pathway, thereby promoting excessive inflammatory responses. The study, published in JCI Insight, provides new insights into the molecular causes of these rare immune disorders. https://insight.jci.org/articles/view/200002