Subprojects
A01Felix Meissner/Florian Ingo Schmidt
Systematic dissection of cytosolic DNA sensing and signalling with nanobodies and proteomics
A02 Stefan Bauer/Thomas Zillinger
Role of self RNA in immune sensing and tolerance
A04 Eva Bartok/Gunther Hartmann
Improving CAR NK cell therapies for breast cancer by spatiotemporally controlled RIG-I activation
A05 Karl-Peter Hopfner
Structural mechanisms of selectivity and regulation of nucleic acid sensors
A07 Andreas Pichlmair
Immune-regulatory functions of CAPN15
A10 Jürgen Ruland
Regulation and function of tumour-cell intrinsic MDA5 signalling
A11 Eicke Latz/Min Ae Lee-Kirsch
Defective RNA quality control and surveillance linked to inflammasome activation
B14 Simon Rothenfusser/Anne Krug
Defining predictors of anti-viral immunity in the yellow fever vaccination model using gene polymorphisms and early innate response patterns
B15 Christian Kurts
Sensing of nucleic acids in immune-mediated glomerulonephritis
B16 Natalio Garbi
Regulation of STING-dependent IFN-β expression by erythrophagocytosis in macrophages during ANCA-associated vasculitis
B17 Axel Roers/Zeinab Abdullah
Regulation of T cell-mediated virus and tumour control by T cell-intrinsic STING signalling
B19 Rayk Behrendt
Nucleic acid sensing of mobile genetic elements
B20 Claudia Günther
Intracellular nucleic acid sensing as a trigger of type I interferon-driven autoimmunity affecting the skin
B21 Min Ae Lee-Kirsch/Johanna Klughammer
Phenotypic, genetic, and transcriptional dissection of type I interferonopathies – a systems approach
B22 Hiroki Kato
Potential treatments for lupus-like nephritis in RIG-I mutant mouse models
A23 Katrin Paeschke/Beate Kümmerer
Recognition and consequences of RNA G4 structures and RNA modifications during stress and viral infection
A25 Carina de Oliveira Mann
Mechanisms of OAS–RNase L pathway regulation
A26 Simon Alberti
Biomolecular condensates as sensors of nucleic acids
A27 Veit Hornung/Thomas Carell
Chemical biology of lysosomal RNA recognition
B29 Sarah Kim-Hellmuth
Deciphering genetic regulatory effects of nucleic acid immunity in human dendritic cell populations
A30 Martin Schlee
Recognition mechanisms of cytosolic DNA receptors
B31 Christine Wolf
TLR7-driven autoimmunity in early-onset systemic lupus erythematosus
A32 Jonathan Bohlen
Autoinflammation triggered by aberrantly matured tRNAs
A33 Daniel Böhmer
Endogenous mapping of ZBP1 signalosomes to dissect cell-fate decisions
A34 Lara Rheinemann
Functional characterisation of new RNA-binding host factors during bunyavirus infection
Z Min Ae Lee-Kirsch
Central Tasks of the Collaborative Research Centre