Publications
2024
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Oxygenator assisted dynamic microphysiological culture elucidates the impact of hypoxia on valvular interstitial cell calcification |
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Dittfeld C, Schmieder F, Behrens S, Jannasch A, Matschke K, Sonntag F, Tugtekin SM. J Biol Eng. 2024 Aug 23;18(1):45., https://jbioleng.biomedcentral.com/articles/10.1186/s13036-024-00441-4 |
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Bioresorbierbare temporäre Herzschrittmacherdrähte – Polymer-ummanteltes Molybdän |
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Dittfeld C BIOspektrum, 30(5):540-540, Wissenschaft · Journal Club , Sept 2024, https://link.springer.com/article/10.1007/s12268-024-2265-z |
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Tissue requirements for the application of aortic valve neocuspidization - appropriate pericardium properties and homogeneity? |
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Dittfeld C, Bähring S, Welzel C, Jannasch A, Matschke K, Tugtekin SM, Alexiou K. J Mater Sci Mater Med. 2024 Apr 29;35(1):26. https://link.springer.com/article/10.1007/s10856-024-06790-2 |
| Erforschen der Aortenklappenstenose im mikrophysiologischen System |
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Dittfeld C, Sonntag F, Tugtekin SM BIOspektrum | 02.24 | 30. Jahrgang, https://doi.org/10.1007/s12268-024-2145-6 https://www.biospektrum.de/artikel/nachgefragt-pd-dr-claudia-dittfeld-im-interview |
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In vivo application of a glutaraldehyde-free, UVA/riboflavin cross-linked bovine pericardium confirms suitability for cardiovascular substitutes |
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Jannasch A, Welzel C, Pablik J, von Hauff E, Galli R, Rix J, Schauer A, Dittfeld C, Tugtekin SM. APL Mater. 12, 011104 (2024) https://doi.org/10.1063/5.0182672 |
2023
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Challenges of aortic valve tissue culture - maintenance of viability and extracellular matrix in the pulsatile dynamic microphysiological system |
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Dittfeld C, Winkelkotte M, Scheer A, Voigt E, Schmieder F, Behrens S, Jannasch A, Matschke K, Sonntag F, Tugtekin SM. Biomater Adv. 2023 Feb 4;147:213328. https://doi.org/10.1186/s13036-023-00377-1 |
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Hemocompatibility tuning of an innovative glutaraldehyde-free preparation strategy using riboflavin/UV crosslinking and electron irradiation of bovine pericardium for cardiac substitutes |
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Dittfeld C, Welzel C, König U, Jannasch A, Alexiou K, Blum E, Bronder S, Sperling C, Maitz MF, Tugtekin SM. Biomater Adv. 2023 Feb 4;147:213328. doi: 10.1016/j.bioadv.2023.213328 |
2022
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Infrared Spectroscopic Verification of a α-Helical Collagen Structure in Glutaraldehyde-Free Crosslinked Bovine Pericardium for Cardiac Implants |
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Welzel C, König U, Jannasch A, Matschke K, Tugtekin SM, Dittfeld C., Steiner G. Life 2022, 12(12), 2035; https://doi.org/10.3390/life12122035 |
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Empagliflozin Preserves Skeletal Muscle Function in a HFpEF Rat Model |
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Winzer EB, Schauer A, Langner E, Augstein A, Goto K, Männel A, Barthel P, Jannasch A, Labeit S, Mangner N, Linke A, Adams V Int. J. Mol. Sci. 2022 23(19), 10989 ; https://doi.org/10.3390/ijms231910989 |
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Targeting MuRF1 by small molecules in a HFpEF rat model improves myocardial diastolic function and skeletal muscle contractility |
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Adams V, Schauer A, Augstein A, Kirchhoff V, Draskowski R, Jannasch A, Goto K, Lyall G, Männel A, Barthel P, Mangner N, Winzer EB, Linke A, Labeit S J Cachexia Sarcopenia Muscle 2022 Mar 17. doi: 10.1002/jcsm.12968. Online ahead of print. |
2021
| Micro-Physiological-Systems enable investigation of hypoxia induced pathological processes in human aortic valve cells and tissues |
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Winkelkotte M, Schmieder F, Behrens S, Salminger D, Jannasch A, Matschke K, Tugtekin SM, Sonntag F, Dittfeld C Current Directions in Biomedical Engineering 2021;7(2): 45-48 DGBMT - STUDIERENDENPREIS 2021 für Maximilian Winkelkotte, 1. Platz https://www.vde.com/de/dgbmt/preise-ehrungen/studentenwettbewerb |
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Establishment of a resazurin-based aortic valve tissue viability assay for dynamic culture in a microphysiological system |
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Dittfeld C, Winkelkotte M, Behrens S, Schmieder F, Jannasch A, Matschke K, Sonntag F, Tugtekin SM Clin Hemorheol Microcirc. 2021 Aug 28. doi: 10.3233/CH-219112. |
| Brillouin confocal microscopy to determine biomechanical properties of SULEEI-treated bovine pericardium for application in cardiac surgery |
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Jannasch A , Rix J , Welzel C, Schackert G, Kirsch M, König U, Koch E, Matschke K, Tugtekin SM, Dittfeld C, Galli R Clin Hemorheol Microcirc. 2021 Aug 27. doi: 10.3233/CH-219119. |
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Use of MALDI Mass Spectrometry Imaging to Identify Proteomic Signatures in Aortic Aneurysms after Endovascular Repair |
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Buerger M, Klein O, Kapahnke S, Mueller V, Frese JP, Omran S, Greiner A, Sommerfeld M, Kaschina E, Jannasch A, Dittfeld C, Mahlmann A, Hinterseher I Biomedicines. 2021 Aug 26;9(9):1088. doi: 10.3390/biomedicines9091088 |
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Sacubitril/Valsartan Improves Diastolic Function But Not Skeletal Muscle Function in a Rat Model of HFpEF |
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Schauer A, Adams V, Augstein A, Jannasch A, Draskowski R, Kirchhoff V, Goto K, Mittag J, Galli R , Männel A, Barthel P, Linke A, Winzer EB Int J Mol Sci 2021 Mar 30;22(7):3570. https://doi: 10.3390/ijms22073570 |
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Optical coherence tomography and multiphoton microscopy offer new options for the quantification of fibrotic aortic valve disease in ApoE -/- mice |
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Jannasch A, Schnabel C, Galli R, Faak S, Büttner P, Dittfeld C, Tugtekin SM, Koch E, Matschke K Sci Rep 2021 Mar 12;11(1):5834. https://doi: 10.1038/s41598-021-85142-4 |
2020
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ZSF1 rat as animal model for HFpEF: Development of reduced diastolic function and skeletal muscle dysfunction |
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Schauer A, Draskowski R, Jannasch A, Kirchhof V, Goto K, Männel A, Barthel P, Augstein A, Winzer E, Tugtekin M, Labeit S, Linke A, Adams V ESC Heart Fail 2020 Oct;7(5):2123-2134. https://doi: 10.1002/ehf2.12915 |
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Molecular Spectroscopic Imaging Offers a Systematic Assessment of Pathological Aortic Valve and Prosthesis Tissue in Biomineralization |
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Dittfeld C, Mieting A, Welzel C, Jannasch A, Matschke K, Tugtekin SM, Steiner G Crystals 2020, 10(9), 763; https://doi.org/10.3390/cryst10090763 |
| Sterilization and Cross-Linking Combined with Ultraviolet Irradiation and Low-Energy Electron Irradiation Procedure: New Perspectives for Bovine Pericardial Implants in Cardiac Surgery. |
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Walker S, Dittfeld C, Jakob A, Schönfelder J, König U, Tugtekin SM. Thorac Cardiovasc Surg. 2020 Mar 1. doi: 10.1055/s-0040-1705100. Online ahead of print. PMID: 32114687 |
2019
2018
| Characterization of thoracal fat depots - expression of adipokines and remodeling factors and impact of adipocyte conditioned media in fibroblast scratch assays |
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Dittfeld C, Bienger K, Andres J, Plötze K, Jannasch A, Waldow T, Tugtekin SM, Matschke K. Clin Hemorheol Microcirc. 2018;70(3):267-280. doi: 10.3233/CH-170341. PMID: 30507567 |
| Treatment with XAV-939 prevents in vitro calcification of human valvular interstitial cells |
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Dittfeld C, Reimann G, Mieting A, Büttner P, Jannasch A, Plötze K, Steiner G, Tugtekin SM, Matschke K. PLoS One. 2018 Dec 7;13(12):e0208774. doi: 10.1371/journal.pone.0208774. eCollection 2018. PMID: 30532256 |
| Subclinical Endocarditis Might be a Hidden Trigger of Early Prosthetic Valve Calcification: A Histological Study |
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Ghazy T, Dittfeld C, Jannasch A, Haase M, Galli R, Plötze K, Waldow T, Matschke K. Heart Surg Forum. 2018 Jul 2;21(4):E300-E304. doi: 10.1532/hsf.1740. PMID: 30084783 |
2017
| Movat Pentachrom stain reveals unexpected high osteogenesis rate in aortic valves |
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Dittfeld C, Haase M, Feilmeier M, Jannasch A, Büttner P, Plötze K, Waldow T, Tugtekin SM. Acta Histochem. 2017 Jun;119(5):533-537. doi: 10.1016/j.acthis.2017.05.006. Epub 2017 Jun 2. PMID: 28579288 |
| The Aldosterone Synthase Inhibitor FAD286 is Suitable for Lowering Aldosterone Levels in ZDF Rats but not in db/db Mice |
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Hofmann A, Brunssen C, Peitzsch M, Balyura M, Mittag J, Frenzel A, Jannasch A, Brown NF, Weldon SM, Gueneva-Boucheva KK, Eisenhofer G, Bornstein SR, Morawietz H. Horm Metab Res. 2017 Jun;49(6):466-471. doi: 10.1055/s-0043-101821. Epub 2017 Apr 20. PMID: 28427090 |
| Elevated Steroid Hormone Production in the db/db Mouse Model of Obesity and Type 2 Diabetes |
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Hofmann A, Peitzsch M, Brunssen C, Mittag J, Jannasch A, Frenzel A, Brown N, Weldon SM, Eisenhofer G, Bornstein SR, Morawietz H Horm Metab Res. 2017 Jan;49(1):43-49. doi: 10.1055/s-0042-116157. Epub 2016 Nov 3. PMID: 27813053 |
2016
| Aldosterone Synthase Inhibition Improves Glucose Tolerance in Zucker Diabetic Fatty (ZDF) Rats |
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Hofmann A, Brunssen C, Peitzsch M, Martin M, Mittag J, Jannasch A, Engelmann F, Brown NF, Weldon SM, Huber J, Streicher R, Deussen A, Eisenhofer G, Bornstein SR, Morawietz H Endocrinology. 2016 Oct;157(10):3844-3855. doi: 10.1210/en.2016-1358. Epub 2016 Aug 15. PMID: 27526033 |
2015
| Antihypertensive and cardioprotective effects of the dipeptide isoleucine-tryptophan and whey protein hydrolysate |
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Martin M, Kopaliani I, Jannasch A, Mund C, Todorov V, Henle T, Deussen A Acta Physiol (Oxf). 2015 Dec;215(4):167-76. doi: 10.1111/apha.12578. Epub 2015 Sep 22. PMID: 26297928 |
2014
| Reversal of myofibroblastic activation by polyunsaturated fatty acids in valvular interstitial cells from aortic valves. Role of RhoA/G-actin/MRTF signalling. |
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Witt W, Büttner P, Jannasch A, Matschke K, Waldow T J Mol Cell Cardiol. 2014 Sep;74:127-38. doi: 10.1016/j.yjmcc.2014.05.008. Epub 2014 May 17. PMID: 24839911 |
| Heart valve stenosis in laser spotlights: Insights into a complex disease |
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Büttner P*, Galli R*, Jannasch A, Schnabel C, Waldow T, Koch E (*first autor) Clin Hemorheol Microcirc. 2014 Jan 1;58(1):65-75. doi: 10.3233/CH-141882. PMID: 25339099 |
| Ex vivo 4D visualization of aortic valve dynamics in a murine model with optical coherence tomography |
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Schnabel C*, Jannasch A*, Faak S*, Waldow T, Koch E (*first autor) Biomedical Optics Express Vol. 5, Iss. 12, pp. 4201–4212 (2014). PMID: 25574432 |
2012
| Sphingosine-1-phosphate induces contraction of valvular interstitial cells from porcine aortic valves |
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Witt W, Jannasch A, Burkhard D, Christ T, Ravens U, Brunssen C, Leuner A, Morawietz H, Matschke K, Waldow T Cardiovasc Res. 2012 Mar 1;93(3):490-7. doi: 10.1093/cvr/cvs002. Epub 2012 Jan 8. PMID: 22232739 |