Article in Computers in Biology and Medicine

Together with our Brazilian collaborators Yuri Garcia Vilela and Artur Fassoni, Lars Thielecke and Ingmar Glauche published an article in Computers in Biology and Medicine on the long-term clonal dynamics of hematopoietic stem cells (HSCs). Using stochastic mathematical modeling applied to longitudinal clonal tracking data from non-human primates, the study demonstrated that a single, homogeneous HSC population cannot explain observed long-term clonal patterns. Instead, a two-compartment model incorporating reversible transitions between active cycling and niche-mediated quiescence provided a substantially improved fit, capturing clone size distributions and the sustained coexistence of small and large clones. These results provide quantitative evidence that heterogeneity and quiescence within the HSC pool are critical for maintaining stable and diverse blood production over time, highlighting how clonal data can uncover fundamental regulatory mechanisms of hematopoiesis.

Link: https://www.sciencedirect.com/science/article/pii/S0010482526002131