New publication in Frontiers in Immunology

Together with colleagues around Prof. Malte von Bonin from the Medical Clinic 1, UKD, Artur Fassoni and Ingmar Glauche analyzed time course data from CAR T-cell therapy in 92 patients with B-cell malignancies and developed a mechanistic model that captures the characteristic phases of CAR T-cell dynamics. The model reveals that identical T-cell kinetics can arise from different tumor characteristics, such as growth rate, initial burden, or antigen density, highlighting the need for individualized tumor burden estimation to improve relapse prediction. Their findings show that early CAR T-cell kinetics within the first month can serve as prognostic markers, paving the way for more accurate risk stratification in patients undergoing CAR T-cell therapy.

The work is now published in Frontiers in Immunology: https://doi.org/10.3389/fimmu.2026.1927857