We study how the hematopoietic system generates and maintains mature blood and immune cells. We use state-of-the-art methods to track and analyze the fate of hematopoietic stem and progenitor cells in their natural environment.

We mainly investigate the frequency, phenotype, and functional properties of tumor infiltrating cells, which play a major role for the clinical outcome of patients and can essentially contribute to the antitumor effects mediated by immuno,- radio- and chemotherapy.

We are investigating the molecular mechanisms that govern T-cell activation and function. Our aim is to provide detailed mechanistic insights into how T-cells work, which can be translated into clinical practice and used to improve cancer immunotherapies.