Publikationen

Selected publications

Mamlouk, S., J. Kalucka, R. P. Singh, K. Franke, A. Muschter, A. Langer, C. Jakob, M. Gassmann, G. B. Baretton and Wielockx, B. Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development. Int. J. Cancer, 15;134(4):849-58, 2014.

Kalucka, K., Ettinger, A. Franke, K., Mamlouk, S., Singh, R.P., Muschter, A., Breier, G., Katschinski, D.M., Huttner, W., Weidemann, A. and Wielockx, B. Epithelial HIF Prolyl Hydroxylase-2 (PHD2) negatively regulates skin wound healing in mice. Mol. Cell. Biol., 33(17): 3426-3438; 2013.

Singh, R. P., Franke K., Kalucka J., Mamlouk S., Muschter A., Gembarska A., Grinenko T., Willam C., Naumann R., Anastassiadis K., Stewart A. F., Bornstein S., Chavakis T., Breier G., Waskow C., and Wielockx B. HIF-prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. Blood. 121(26):5158-5166, 2013.

Franke, K., Kalucka, J., Mamlouk, S., Singh, R.P., Muschter, A., Weidemann, A., Iyengar, V., Jahn, S., Wieczorek, K., Geiger, K., Muders, M., Sykes, A.M., Poitz, D., Ripich, T., Otto, T., Bergmann, S., Breier, G., Baretton, G., Fong, G., Greaves, D.R., Bornstein, S., Chavakis, T., Fandrey, J., Gassmann, M., and Wielockx, B. HIF-1α is a Protective Factor in Conditional PHD2 Deficient Mice Suffering from Severe HIF-2α-Induced Excessive Erythropoiesis. Blood, 121(8):1436-1445, 2013.

Klotzsche- von Ameln, A., Muschter, A., Heimesaat, M. M. Breier, G. and Wielockx, B.. "HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFbeta activation." Cancer Biol Ther 13(4): 216-223, 2012.

Klotzsche-von Ameln, A., Muschter, A., Mamlouk, S., Kalucka, J., Prade, I., Franke, K., Rezaei, M., Poitz, D.M., Breier, G., and Wielockx, B. Inhibition of HIF Prolyl Hydroxylase-2 Blocks Tumor Growth in Mice through the Anti-Proliferative Activity of TGFβ. Cancer Res., 1;71(9):3306-16, 2011.

Wielockx, B., Staelens, J., Puimège, L., Van Roy, F. and Libert, C.  Description and chromosomal mapping of the resistance against tumor necrosis factor–induced lethal shock of DBA/2 mice. J. Immunol. 178(8):5069-75, 2007.

Wullaert, A*., Wielockx, B.*, Van Huffel, S., Bogaert, V., De Geest, B., Papeleu, P., El Bakkouri, K., Heyninck, K., Libert, C., and Beyaert R., Adenoviral gene transfer of ABIN-1 protects mice from TNF/Galactosamine-induced acute liver failure and lethality, Hepatology; 42(2), 381-9, 2005. (* equally contributed).

Wielockx, B., Lannoy, K., Shapiro, S. D., Itoh, T., Itohara, S., Vandekerckhove, J., and Libert, C., Inhibition of Matrix Metalloproteinases blocks TNF-induced Lethal Hepatitis and apoptosis, Nat. Med. 7, 1202-1208, 2001.