Publikationen

Selected publications

 

  • Chavakis T et al: Staphylococcus aureus extracellular adherence protein (Eap) serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes. Nature Medicine. 8:687-693, 2002.
  • Santoso, S., Sachs, U.J., Kroll, H., Linder, M, Preissner, K.T., and Chavakis, T.: The Junctional Adhesion Molecule-3 on human platelets is a counter-receptor for the leukocyte integrin Mac-1. J Exp Med. 196:679-691, 2002.
  • Chavakis, T., Bierhaus, A., Al-Fakhri, N., Schneider, D., Witte, S., Linn, T., Nagashima, M., Morser, J., Arnold, B., Preissner, K.T., and Nawroth, P.P.: The Pattern Recognition Receptor (RAGE) is a Counter-receptor for Leukocyte Integrins: A novel pathway for inflammatory cell recruitment. J. Exp. Med. 198:1507-15, 2003.
  • Chavakis, E., Aicher, A., Heeschen, C., Sasaki, K., Kaiser, R., El Makhfi, N., Urbich, C., Peters, T., Scharffetter-Kochanek, K., Zeiher, A.M., Chavakis, T., and Dimmeler, S.: Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells. J Exp Med. 201:63-72, 2005.
  • Xie, C., Alcaide, P., Geisbrecht, B., Schneider, D., Herrmann, M., Preissner, K.T., Luscinskas, F.W., and Chavakis, T.: Suppression of Experimental Autoimmune Encephalomyelitis by the anti-inflammatory Extracellular Adherence Protein (Eap) of Staphylococcus aureus. J Exp Med 203:985-94, 2006
  • Orlova, V., Economopoulou, M., Lupu, F., Santoso, S. and Chavakis, T. Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts. J Exp Med. 203:2703-14, 2006.
  • Isermann, B., Vinnikov, I., Madhusudhan, T., Herzog, S., Huntscha, S., Blausitz, J., Corrat, M., Buender, R., Zeier, M., Blessing, E., Chavakis, T., Esmon, C., Weiler, H., Bierhaus, A., Nawroth, P.P. The thrombomodulin protein C system protects against endothelial dysfunction and diabetic nephropathy by inhibiting glucose induced apoptosis. Nature Medicine, 13:1349-58, 2007.
  • Orlova, V.V., Choi, E.Y., Xie, C., Chavakis, E., Bierhaus, A., Ihanus, E., Ballantyne, C.M., Gahmberg, C.G., Bianchi, M.E., Nawroth, P.P., and Chavakis, T. A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin. EMBO J. 26:1129-39, 2007.
  • Choi, E.Y., Orlova, V.V., Fagerholm, S., Nurmi, S., Zhang, L., Ballantyne, C.M., Gahmberg, C.G., and Chavakis, T. Regulation of beta2-integrin mediated inflammatory cell recruitment by cbl-b and 14-3-3 proteins. BLOOD, 2008, 111:3607-14. 
  • Choi EY, Chavakis E, Czabanka MA, Langer H, Fraemohs L, Economopoulou M, Kundu RK, Orlandi A, Zheng YY, Prieto DA, Ballantyne CM, Constant SL, Aird W, Papayannopoulou T, Gahmberg CG, Udey MC, Vajkoczy P, Quertermous T, Dimmeler S, Weber C, and Chavakis T. Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Science, 2008, 322:1101-04.        
  • Economopoulou, M., Langer, H.F., Celeste, A., Orlova, V.V., Choi, E.Y., Ma, M., Vassilopoulos, A., Callen, E., Deng, C., Bassing, C.H., Boehm, M., Nussenzweig, A. and Chavakis, T. Histone H2AX is integral to hypoxia-driven neovascularisation. Nature Medicine, 15:553-8, 2009.
  • Langer, H.F., Chung, K.J., Orlova, V.V., Choi, E.Y., Kaul, K., Kruhlak, M.J., Alatsatianos, M., DeAngelis, R.A., Roche, P.A., Magotti, P., Li, X., Economopoulou, M., Rafail, S., Lambris, J.D., and Chavakis, T. Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis. BLOOD, 116:4395-403, 2010.           
  • Wolf, R., Mascia, F., Dharamsi1, A., Howard, O.M.Z., Cataisson, C., Bliskovski, V., Winston, J., Feigenbaum, L., Lichti, L.,Ruzicka, T., Chavakis, T. and Yuspa, S.H. A Gene from a Psoriasis Susceptibility Locus Primes the Skin for Inflammation. Science Translational Medicine, 2:61ra90, 2010.
  • Langer, H.F., Orlova, V.V., Xie, C., Kaul, S., Schneider, D., Lonsdorf, A.S., Fahrleitner, M., Choi, E.Y., Dutoit, V., Pellegrini, M., Grossklaus, S., Nawroth, P.P., Baretton, G., Santoso, S., Hwang, S.T., Arnold, B., and Chavakis, T. A novel function of Junctional Adhesion Molecule-C in mediating melanoma cell metastasis. Cancer Research, 71:4096-4105, 2011            
  • Woodfin, A., Voisin, M.B., Bauer, M., Colom, B., Caille, D., Diapouli, F.M., Nash, G.B., Chavakis, T., Albelda, S., Rainger, G.E., Meda, P., Imhof, B.A. and Nourshargh, S. Junctional adhesion molecule-C (JAM-C) is a key regulator of polarized neutrophil transendothelial cell migration in vivo. Nature Immunology, 12:761-9, 2011
  • Eskan, M.A., Jotwani, R., Abe, T., Chmelar, J., Lim, J.H., Liang, S., Ciero, P., Krauss, J., Li, F., Rauner, M., Hofbauer, L.C., Choi, E.Y., Chung, K.J., Hashim, A., Curtis, M., Chavakis, T.*, Hajishengallis, G.* 2012. The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nature Immunology, 13: 465-473, 2012- COVER ARTICLE  *contributed equally as senior authors to the work
  • Zhang F, Li Y, Tang Z, Kumar A, Lee C, Zhang L, Zhu C, Klotzsche-von Ameln A, Wang B, Gao Z, Zhang S, Langer HF, Hou X, Jensen L, Ma W, Wong W, Chavakis T, Liu Y, Cao Y, Li X. Proliferative and Survival Effects of PUMA Promote Angiogenesis. Cell Rep. 2:1272-85, 2012.
  • Langer, H.F., Choi, E.Y., Zhou, H., Schleicher, R., Chung, K.J., Tang, Z., Göbel, K., Bdeir, K., Chatzigeorgiou, A., Wong, C., Bhatia, S., Kruhlak, M.J., Rose, J., Burns, J.B., Hill, K.E., Qu, H., Zhang, Y., Lehrmann, E., Becker, K.G., Wang, Y., Simon, D.I., Nieswandt, B., Lambris, J.D., Li, X., Meuth, S.G., Kubes, P., and Chavakis, T. Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circulation Research, 110:1202-10, 2012  
  • Chatzigeorgiou A, Karalis KP, Bornstein SR, Chavakis T. Lymphocytes in obesity-related adipose tissue inflammation. Diabetologia. 55: 2583-92, 2012 
  • Hajishengallis G and Chavakis T. Endogenous modulators of inflammatory cell recruitment. Trends Immunol, 34:1-6, 2013
  • Chmelar J, Chung KJ, Chavakis T.The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance. Thromb Haemost. 109:399-406, 2013 
  • Kanczkowski W, Chatzigeorgiou A, Grossklaus S, Sprott D, Bornstein SR, Chavakis T. Role of the endothelial-derived endogenous anti-inflammatory factor Del-1 in inflammation-mediated adrenal gland dysfunction. Endocrinology 154:1181-9, 2013. 
  • Singh RP, Franke K, Kalucka J, Mamlouk S, Muschter A, Gembarska A, Grinenko T, Willam C, Naumann R, Anastassiadis K, Stewart AF, Bornstein S, Chavakis T, Breier G, Waskow C, Wielockx B. HIF-prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. Blood. 121: 5158-66, 2013
  • Phieler J, Chung KJ, Chatzigeorgiou A, Klotzsche-von Ameln A, Garcia-Martin R, Sprott D, Moisidou M, Tzanavari T, Ludwig B, Baraban E, Ehrhart-Bornstein M, Bornstein SR, Mziaut H, Solimena M, Karalis KP, Economopoulou M, Lambris JD, Chavakis T. The complement anaphylatoxin c5a receptor contributes to obese adipose tissue inflammation and insulin resistance. J Immunol. 191: 4367-74, 2013
  • Mitroulis I, Kang YY, Gahmberg CG, Siegert G, Hajishengallis G, Chavakis T*, Choi EY*. Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin. Thromb Haemost. 2013, Dec 19;111(5) *contributed equally as senior author to the work
  • Langer HF and Chavakis T. Platelets and neurovascular inflammation. Thromb Haemost, 110:888-93, 2013
  • Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, …., Nicolaes G, Chavakis T*, Lutgens E*. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc Natl Acad Sci U S A. 111:2686-91, 2014 *contributed equally as senior authors to the work
  • Phieler J, Garcia-Martin R, Lambris J and Chavakis T. The role of the complement system in metabolic organs and metabolic diseases. Seminars in Immunology, 25: 47-53, 2013 
  • Moutsopoulos NM, Konkel J, Sarmadi M, Eskan MA, Wild T, Dutzan N, Abusleme L, Zenobia C, Hosur KB, Abe T, Uzel G, Chen W, Chavakis T, Holland SM, Hajishengallis G. Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17-Driven Inflammatory Bone Loss. Sci Transl Med. 2014 Mar 26;6:229ra40
  • Chatzigeorgiou A, Chung KJ, Garcia-Martin R, Alexaki I, ….. Karalis KP, Lutgens E, and Chavakis T. Dual role of B7 costimulation in obesity-related non-alcoholic steatohepatitis (NASH) and metabolic dysregulation. Hepatology, 2014, Epub ahead of print

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Franziska Schmidt
Last modified: May 04, 2016