Publikationen
L.V. Duncker, S. Richter, R. Galli, M. Meinhardt, L.C. Hoffmann, K. Kirsche, L. Großer, A. Temme, I.Y. Eyüpoglu, O. Uckermann „Label-free multiphoton microsocopy for intraoperative identification of glioma features and tumor heterogeneity”, Frontiers in Oncology, 16, https://doi.org/10.3389/fonc.2026.1802324, (2026)
M. Kotula, F. Roth, P. Simon, W. Carrillo-Cabrera, D. Potorochin, A. Makarova, R. Galli, E. Brendler, V. M. Gun'ko, I. Iatsunskyi, W. Kukułka, A. Martyła, R. Przekop, M. Kuznowicz, P. Krawczyk, A. Szczurek, D. Vyalikh, A. Springer, T. Jesionowski, H. Ehrlich “Nanoarchitectonics of centimeter-sized 3D multiphase carbon constructs created via carbonization of the sustainable biomaterial spongin at 2200 °C”, Materials Today Adcances 30, 100780, https://doi.org/10.1016/j.mtadv.2026.100780, (2026)
R. Galli, S. Korn, D. Aust, G.B. Baretton, J. Weitz, E. Koch, C. Riediger “Label-free multiphoton microscopy and machine learning for recognition of hepatocellular carcinoma”, Scientific Reports 16:8734, https://doi.org/10.1038/s41598-026-43831-y, (2026)
L.C. Hoffmann, R. Galli, S. Richter, I. Eyüpoglu, O. Uckermann “Help from outer space: Denoising of confocal laser endomicroscopic images of brain tissue using pretrained astronomy software”, Interdisciplinary Neurosurgery: Advanced Techniques and Case Management, 43:102222, https://doi.org/10.1016/j.inat.2026.102222, (2026)
J. Reinhold, C. Schnabel, P. Cimalla, L. Kirsten, E. Koch, J. Walther “Setup of a Polarization Sensitive Ultra-high Resolution Visible-light OCT”, https://doi.org/10.1117/12.3098539, Proceedings of SPIE 13939, (2025)
J. Reinhold*, C. Schmidt*, M. Sasse, J. Rohr, R. Köhler, J. Golde, L. Kirsten, C. Hannig, E. Koch, J. Walther “ Polarization-sensitive optical coherence tomography with single input for imaging the polarization state within various samples”, Proceedings of SPIE 13939, https://doi.org/10.1117/12.3098538, (2025)
J. Rix, S. Steuer, J. Golde, F. Husein, F. Lochmann, S. Melcher, G. Steiner, J. Walther, F. Raiskup, R. Khoramnia, R. Herber “ Investigation of the Microscopic and Molecular Processes Underlying the Corneal Cross-Linking Therapy”, Proceedings of SPIE 13936, https://doi.org/10.1117/12.3097970, (2025)
R. Galli, T. Leonidou, J. Rix, K. Kirsche, E. Koch, I.Y. Eyüpoglu, O. Uckermann “Biomechanics of Glioblastoma Tissue: Insights form In Vitro Models using Brillouin and Raman Spectroscopy”, Proceedings of SPIE 13936, https://doi.org/10.1117/12.3097969, (2025)
R. Galli, S. Korn, D. Aust, G. Baretton, G.B. Weitz, E. Koch, C. Riediger “Recognition of Human Liver Cancers by Label-free Nonlinear Microscopy and Machine Learning”, Proceedings of SPIE 13934, https://doi.org/10.1117/12.3097864, (2025)
J. Grundmann, C. Hannig, S. Steuer, T. Rosenauer, L. Kirsten, E. Koch, J. Golde, J. Walther “Depolarization-Based Multimodal Optical Imaging of Carious Lesions”, Journal of Biophotonics, 0:e202500422, https://doi.org/10.1002/jbio.202500422, (2025)
J. Rix, T. Leonidou, A. Temme, O. Uckermann, R. Galli “Fingerpint Raman spectrocopy for identification of hydration-dependent Brillouin shift variations in brain tumor tissue”, Vibrantional Spectroscopy, 141:103866, https://doi.org/10.1016/j.vibspec.2025.103866, (2025)
R. Galli, J. Rix, T. Leonidou, K. Kirsche, E. Koch, A. Temme, I. Eyüpoglu, O. Uckermann “Exploring the biomechanical complexity of glioblastoma spheroids and organoids with co-localized Brillouin and Raman microspectroscopy”, Biochemistry and Biophysics Reports 44, 102227, https://doi.org/10.1016/j.bbrep.2025.102227, (2025)
J. Rix*, S. Steuer*, J. Golde, F. Husein, F. Lochmann, S. Melcher, G. Steiner, R. Galli, J. Walther, F. Raiskup, R. Khoramnia, R. Herber „Investigation of corneal hydration and the impact of cross-linking therapy on water retention using Brillouin spectroscopy, Raman spectroscopy and polarization-seisitive optical coherence tomography”, Frontiers in Bioengineering and Biotechnology 13:1576809, https://doi.org/10.3389/fbioe.2025.1576809, (2025)
J. Pietzsch, M. Toussaint, C. K. Donat, A. Doctor, S. Meister, J. Wodtke, M. Laube, F. Hofheinz, J. Rix, W. Deuther-Conrad, C. Haase-Kohn “Exploring the Role of Peripheral Macrophages in Glioma Progression: The Metabolic Significance of Cyclooxygenase-2 (COX-2)”, International Journal of Molecular Sciences, 26(13), 6198, https://doi.org/10.3390/ijms26136198, (2025)
H. Ehrlich, I. Miksik, M.V. Tsurkan, P. Simon, F. Porzucek, J.D. Rybka, M. Mankowska, R. Galli, C. Viehweger, E. Brendler, A. Voronkina, M. Pajewska-Szmyt, A. Tabachnik, K.R. Tabachnick, C. Vogt, M. Wysokowski, T. Jesionowski, T. Buchwald, M. Szybowicz, K. Skieresz-Szewczyk, H. Jackowiak, A. Ereskovsky, A.C.S. de Alcantara, A.M. dos Santos, C.H.S. da Consta, S.E. Arevalo, M.S. Skaf, M.J. Buehler, “Discovery of mammalian collagens I and III within ancient poriferan biopolymer spongin”, Nature Communications, 16:2515, https://doi.org/10.1038/s41467-025-57460-y, (2025)
S. Steuer, J. Morgenstern, L. Kirsten, M. Neudert, E. Koch, J. Golde, "Insights into the fiber architecture of the human tympanic membrane by visualizing the depth-resolved optic axis orientation," Proc. SPIE 13294, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2025, 1329404, https://doi.org/10.1117/12.3054093, (2025)
R. Galli, O. Uckermann “Toward cancer detection by label-free microscopic imaging in ocological surgery: Techniques, instrumentation and applications”, Micron 191, https://doi.org/10.1016/j.micron.2025.103800, (2025)
M. Reichenbach, S. Richter, R. Galli, M. Meinhardt, K. Kirsche, A. Temme, D. Emmanouilidis, W. Polanski, I. Prilop, D. Krex, S.B. Sobottka, T.A. Juratili, I.Y. Eyüpoglu, O. Uckermann “Clinical confocal laser endomicroscopy for imaging of autofluorescence signals of human brain tumors and non-tumor brain”, Journal of Cancer Research and Clinical Oncology 151:19, https://doi.org/10.1007/s00432-024-06052-2, (2025)
O. Uckermann*, J. Ziegler*, M. Meinhardt, S. Richter, G. Schackert, I.Y. Eyüpoglu, M.M. Hijazi, D. Krex, T.A. Juratli, S.B. Sobottka, R. Galli “Raman and autofluorescence spectroscopy for in situ identification of neoplastic tissue during surgical treatment of brain tumors”, Journal of Neuro-Oncology, https://doi.org/10.1007/s11060-024-04809-w, (2024)
R. Galli*, F. Lehner*, S. Richter, K. Kirsche, M. Meinhardt, T.A. Juratli, A. Temme, M. Kirsch, R. Warta, C. Herold-Mende, F.L. Ricklefs, K. Lamszus, P. Sivers, F. Sahm, I.Y. Eyüpoglu, O. Uckermann „Prediction of WHO grade and methylation class of aggressive meningiomas: Extraction of diagnostic information from infrared spectroscopic data”, Neuro-Oncology Advances, 61(1), vdae082, https://doi.org/10.1093/noajnl/vdae082, (2024)
J. Grundmann, J. Golde, S. Steuer, F. Tetschke, L. Kirsten, J. Walther, E. Koch, C. Hannig „Visualization of carious lesions with polarized and depolarized light microscopy”, Biomedical Optics Express, 15(5), S. 3018 – 3036, https://doi.org/10.1364/BOE.514904, (2024)
J. Morgenstern, T. Kreusch, J. Golde, S. Steuer, S. Ossmann, L. Kirsten, J. Walther, T. Zahnert, E. Koch, M. Neudert „In vivo thickness oft he healthy tympanic membrane determined by optical coherence tomography”, Otology & Neurotology 45(3), e256-e262, https://doi.org/10.1097/MAO.0000000000004132, (2024)
P. Liu, S. Steuer, J. Golde, J. Morgenstern, Y. Hu, C. Schieffer, S. Ossmann, L. Kirsten, S. Bodenstedt, M. Pfeiffer, S. Speidel, E. Koch, M. Neudert „The Dresden in vivo OCT dataset for automatic middle ear segmentation“, Scientific data 11(1), 242, https://doi.org/10.1038/s41597-024-03000-0, (2024)
S.M.M. Hund, J. Golde, F. Tetschke, S. Basche, M. Meier, L. Kirsten, E. Koch, C. Hannig, J. Walther „Polarization-Sensitive Optical Coherence Tomography for Monitoring De- and Remineralization of Bovine Enamel in Vitro”, Diagnostics 14(4) , https://doi.org/10.3390/diagnostics14040367, (2024)
A. Jannasch, C. Welzel, J. Pablik, E. von Hauff, R. Galli, J. Rix, A. Schauer, C. Dittfeld, S.M. Tugtekin „In vivo application of a glutaraldehyde-free, UVA/riboflavin cross-linked bovine pericardium confirms suitability for cardiovascular substitutes”, APL materials 12(1), 01114, https://doi.org/10.1063/5.0182672, (2024)
R. Galli, O. Uckermann “Vibrational spectroscopy and multiphoton microscopy for label-free visualization of nervous system degeneration and regeneration”, Biophysical Reviews, https://doi.org/10.1007/s12551-023-01158-2, (2023)
S. Steuer, J. Morgenstern, A. Jannasch, L. Kirsten, E. Koch, M. Neudert, J. Golde „Morphologic analysis of the human tympanic membrane by polarization-sensitive OCT and polarized light microscopy” Proceedings of SPIE 12632, 126320G, (2023)
Y. Gruda, M. Albrecht, M. Buckova, D. Haim, G. Lauer, E. Koch, K. Joehrens, C. Schnabel, J. Golde, J. Li, R.A. McLaughlin, J. Walther „Characteristics of Clinically Classified Oral Lichen Planus in Optical Coherence Tomography: A Descriptive Case-Series Study”, Diagnostics 13(16), 2642, https://doi.org/10.3390/diagnostics13162642, (2023)
J. Golde, J. Morgenstern, P. Liu, S. Ossmann, L. Kirsten, S. Steuer, S. Speidel, E. Koch, S. Bodenstedt, M. Neudert „Data-informed imaging: How radiography and shape models support endoscopic OCT imaging of the middle ear”, Proceedings of SPIE 12354, 1235405, (2023)
P. Liu, J. Golde, J. Morgenstern, S. Bodenstedt, C. Li, Z. Chen, E. Koch, M. Neudert, S. Speidel „Non-rigid point cloud registration for middle ear diagnostics with endoscopic optical coherence tomography”, International Journal of Computer Assisted Radiology and Surgery, https://doi.org/10.1007/s11548-023-02960-9, (2023)
M. Völkner, F. Wagner, T. Kurth, A.M. Sykes, C. Del Toro Runzer, L.J.A. Ebner, C. Kavak, V.I. Alexaki, P. Cimalla, M. Mehner, E. Koch, M.O. Karl “Modeling inducible neuropathologies of the retina with differential phenotypes in organoids”, Front Cell Neurosci, 17:1106287, https://doi.org/10.3389/fncel.2023.1106287, (2023)
S. Steuer, J. Morgenstern, L. Kirsten, M. Bornitz, M. Neudert, E. Koch, J. Golde „In vivo microstructural investigation oft he human tympanic membrane by endoscopic polarization-sensitive optical coherence tomography”, Journal of Biomedical Optics, Vol. 28 (12), https://doi.org/10.1117/1.JBO.28.12.121203, (2023)
R. Galli, T. Siciliano, D. Aust, S. Korn, K. Kirsche, G.B. Baretton, J. Weitz, E. Koch, C. Riediger „Label-free multiphoton microscopy enables histopathological assessment of colorectal liver metastases and support automated classificaton of neoplastic tissue”, Scientific Reports 13,4274, https://doi.org/10.1038/s41598-023-31401-5, (2023)
R. Galli, T. Juratli, O. Uckermann “Clinical Raman spectroscopy of brain tumors from an interdisciplinary perspective”, Clinical Neuropathology 42, https://doi.org/10.5414/NP301522, (2023)
G. Steiner, R. Galli, G. Preusse, S. Michen, M. Meinhardt, A. Temme, S.B. Sobottka, T.A. Juratli, E. Koch, G. Schackert, M. Kirsch, O. Uckermann „A new approach for clinical translation of infrared spectroscopy: exploitation of the signature of glioblastoma for general brain tumor recognition“, Journal of Neuro-Oncology, https://doi.org/10.1007/s11060-022-04204-3, (2022)
G. Preuße, V. Porstmann, T. Bartels, C. Schnabel, R. Galli, E. Koch, M. Oelschlägel, O. Uckermann, G. Steiner „High sensitive and quick in ovo sexing of domestic chicken eggs by two-wavelength fluorescence spectroscopy”, Analytical and Bioanalytical Chemistry, https://doi.org/10.1007/s00216-022-04446-0, (2022)
J. Wu, T. Wang, O. Uckermann, R. Galli, G. Schackert, L. Cao, J. Czarske, R. Kuschmierz „Learned end-to-end high-resolution lensless fiber imaging towards real-time cancer diagnosis”, Scientific Reports 12, 18846, https://doi.org/10.1038/s41598-022-23490-5, (2022)
R. Vosahlo, J. Golde, J. Walther, E. Koch, C. Hannig, F. Tetschke „Differentiation of Occlusal Discolorations and Carious Lesions with Hyperspectral Imaging In Vitro”, Appl. Sci., 12, 7312, https://doi.org/10.3390/app12147312, (2022)
J. Rix, O. Uckermann, K. Kirsche, G. Schackert, E. Koch, M. Kirsch, R. Galli “Correlation of biomechanics and cancer cell phenotype by combined Brillouin and Raman spectroscopy of U87-MG glioblastoma cells”, Journal of the Royal Society Interface, 19: 20220209, https://doi.org/10.1098/rsif.2022.0209, (2022)
J. Rix, M. Rüsing, R. Galli, J. Golde, S. Reitzig, L.M. Eng, E. Koch „Brillouin and Raman imaging of domain walls in periodically poled 5%-MgO:LiNbO3”, Optics Express, 30(4), S. 5051 – 5062, https://doi.org/10.1364/OE.447554, (2022)
J. Walther, J. Golde, M. Albrecht, B. Quirk, L. Scolaro, R. Kirk, Y. Gruda, C. Schnabel, F. Tetschke, K. Joehrens, D. Haim, M. Buckova, J. Li, R. Mclaughlin “A handheld fiber-optic probe to enable optical coherence tomography of oral soft tissue”, IEEE Tran Biomed Eng, https://doi.org/10.1109/TBME.2022.3141241, (2022)
A. Jannasch*, J. Rix*, C. Welzel, G. Schackert, M. Kirsch, U. König, E. Koch, K. Matschke, S.M. Tugtekin, C. Dittfeld, R. Galli „Brillouin confocal microscopy to determine biomechanical properties of SULEEI-treated bovine pericardium for application in cardiac surgery”, Clinical Hemorheology and Microcirculation, 79(1), S. 179-192, https://doi.org/10.3233/CH-219119, (2021)
D. Tsurkan, P. Simon, C. Schimpf, M. Motylenko, D. Rafaja, F. Roth, D. S. Inosov, A. A. Makarova, I. Stepniak, I. Petrenko, A. Springer, E. Langer, A. A. Kulbakov, M. Avdeev, A. R. Stefankiewicz, K. Heimler, O. Kononchuk, S. Hippmann, D. Kaiser, C. Viehweger, A. Rogoll, A. Voronkina, V. Kovalchuk, V. V. Bazhenov, R. Galli, M. Rahimi-Nasrabadi, S. L. Molodtsov, P. Rahimi, S. Falahi, Y. Joseph, C. Vogt, D. V. Vyalikh, M. Bertau, H. Ehrlich “Extreme Biomimetics: Designing of the First Nanostructured 3D Spongin–Atacamite Composite and its Application”, Advanced Materials 33(30), 2101682, https://doi.org/10.1002/adma.202101682, (2021)
M. Albrecht, C. Schnabel, J. Mueller, J. Golde, E. Koch, J. Walther „In Vivo Endoscopic Optical Coherence Tomography of the Healthy Human Oral Mucosa: Qualitative and Quantitative Image Analysis”, Diagnostics 10(10), 827, https://doi.org/10.3390/diagnostics10100827, (2020)
F. Tetschke, J. Golde, T. Rosenauer, S. Basche, J. Walther, L. Kirsten, E. Koch, C. Hannig “Correlation between Lesion Progression and Depolarization Assessed by Polarization-Sensitive Optical Coherence Tomography”, Applied Sciences 10, 2971, https://doi.org/10.3390/app10082971, (2020)
J. Walther, Q. Li, M. Villiger, S. S. Frah, E. Koch, K. Karnowski, D. Sampson „Depth-resolved birefringence imaging of collagen fiber organization in the human oral mucosa in vivo“, Biomedical Optics Express 10(4), S. 1942 – 1956, https://doi.org/10.1364/BOE.10.001942, (2019)
L. Kirsten, M. Schindler, J. Morgenstern, M.T. Erkkilä, J. Golde, J. Walther, P. Rottmann, M. Kemper, M. Bornitz, M. Neudert, T. Zahnert, E. Koch “Endoscopic optical coherence tomography with wide field-of-view for the morphological and functional assessment of the human tympanic membrane”, Journal of Biomedical Optics 24(3), 031017, https://doi.org/10.1117/1.JBO.24.3.031017, (2019)
M. Schindler, L. Kirsten, J. Morgenstern, J. Golde, M. Erkkilä, J. Walther, M. Kemper, M. Bornitz, M. Neudert, T. Zahnert, E. Koch „Imaging of the human tympanic membrane by endoscopic optical coherence tomography“, Current Directions in Biomedical Engineering 4(1), S. 305 – 308, (2018)
J. Golde, F. Tetschke, J. Walther, T. Rosenauer, F. Hempel, C. Hannig, E. Koch, L. Kirsten „Cross-sectional and en-face depolarization imaging for the assessment of dental lesions“,Current Directions in Biomedical Engineering 4(1), S. 301 – 304, (2018)
J. Golde, F. Tetschke, J. Walther, T. Rosenauer, F. Hempel, C. Hannig, E. Koch, L. Kirsten “Detection of carious lesions utilizing depolarization imaging by polarization sensitive optical coherence tomography”, Journal of Biomedical Optics 23(7), S. 041203-1 – 041203-8, doi:10.1117/1.JBO.23.7.071203, (2018)
F. Tetschke, L. Kirsten, J. Golde, J. Walther, R. Galli, E. Koch, C. Hannig “Application of optical and spectroscopic technologies for the characterization of carious lesions in vitro”, Biomed Tech, 63(5), S. 595 – 602, https://doi.org/10.1515/bmt-2017-0133, (2018)
J. Walther, C. Schnabel, F. Tetschke, T. Rosenauer, J. Golde, N. Ebert, M. Baumann, C. Hannig, E. Koch “In vivo imaging in the oral cavity by endoscopic optical coherence tomography”, Journal of Biomedical Optics, 23(7), 071207, doi:10.1117/1.JBO.23.7.071207, (2018)
P. Cimalla, J. Walther, C. Mueller, S. Almedawar, B. Rellinghaus, D. Wittig, M. Ader, M.O. Karl, R.H.W. Funk, M. Brand, E. Koch “Improved Imaging of Magnetically Labeled Cells Using Magnetomotive Optical Coherence Tomography”, Applied Sciences 7(5), S. 444, doi:10.3390/app7050444, (2017)
L. Kirsten, J. Morgenstern, M.T. Erkkilä, M. Schindler, J. Golde, J. Walther, M. Kemper, T. Stoppe, M. Bornitz, M. Neudert, T. Zahnert, E. Koch “Functional and morphological imaging of the human tympanic membrane with endoscopic optical coherence tomography”, Current Directions in Biomedical Engineering 3(2), S. 99 – 101, https://doi.org/10.1515/cdbme-2017-0021, (2017)
J. Walther, E. Koch “Flow Measurement by Lateral Resonant Doppler Optical Coherence Tomography in the Spectral Domain”, Applied Sciences 7(4), S. 382, doi:10.3390/app7040382, (2017)
J. Walther, C. Schnabel, N. Ebert, M. Baumann, E. Koch “3D handheld endoscope for optical coherence tomography of the human oral mucosa in vivo”, Proceedings of SPIE 10416, 104160F-1 – 104160F-4, (2017)
J. Walther, E. Koch “Lateral resonant Doppler flow measurement by spectral domain optical coherence tomography”, Proceedings of SPIE 10416, 1041602-1 – 1041602-4, (2017)
J. Walther, E. Koch “Impact of a detector dead time in phase-resolved Doppler analysis using spectral domain optical coherence tomography”, Journal of the Optical Society of America A 34(2), S. 241-251, DOI: 10.1364/JOSAA.34.000241, (2017)
J. Walther, J. Golde, L. Kirsten, F. Tetschke, F. Hempel, T. Rosenauer, C. Hannig, E. Koch “In vivo imaging of human oral hard and soft tissues by polarization-sensitive optical coherence tomography“, Journal of Biomedical Optics, 22(12), 121717, DOI: 10.1117/1.JBO.22.12.121717, (2017)