Publications
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Ballin,M., Griep,W., Patel,M., Karl,M., Mentrup,T., Rivera-Monroy,J., Foo,B., Schwappach,B., and Schröder,B. (2022)
The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins.
FEBS J 290, 2320-2337 -
Contreras,W., Wiesehöfer,C., Schreier,D., Leinung,N., Peche,P., Wennemuth,G., Gentzel,M., Schröder,B., and Mentrup,T. (2022)
C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly.
Science Advances 8, eabo6049. -
Mentrup,T., Stumpff-Niggemann,A.Y., Leinung,N., Schlosser,C., Schubert,K., Wehner,R., Tunger,A., Schatz,V., Neubert,P., Gradtke,A.C., Wolf,J., Rose-John,S., Saftig,P., Dalpke,A., Jantsch,J., Schmitz,M., Fluhrer,R., Jacobsen,I.D. and Schröder,B. (2022)
- Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis. Nat Comm 13: 1880.
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Mentrup,T. and Schröder,B. (2022)
Signal peptide peptidase-like 2 proteases: Regulatory switches or proteasome of the membrane?
Biochim. Biophys. Acta Mol Cell Res 1869:119163. - Mentrup,T., Cabrera-Cabrera,F. and Schröder,B. (2021)
Proteolytic regulation of the Lectin-like oxidised lipoprotein receptor LOX-1
Front Cardiovasc Med 7: 594441. -
Klionsky,D.J., et al., Schröder,B., et al., Tong,C.K. (2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Autophagy 17, 1-382. -
Gradtke, A.C., Mentrup,T., Lehmann,C.H.K., Cabrera-Cabrera,F., Desel,C. Okakpu,D., Assmann, M., Dalpke,A., Schaible, U., Dudziak,D., and Schröder, B. (2021)
Deficiency of the intramembrane protease SPPL2a alters anti-mycobacterial cytokine responses of dendritic cells.
J Immunol 206, 164-180. -
Flynn,C.M., Garbers,Y., Düsterhöft,S., Wichert,R., Lokau,J., Lehmann, C.H.K., Dudziak,D., Schröder,B., Becker-Pauly,C., Rose-John,S., Aparicio-Siegmund,S. and Garbers,C. (2020)
Cathepsin S provokes interleukin-6(IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro.
Scientific Reports 10, 21612. - Mentrup,T., Cabrera-Cabrera,F., Fluhrer,R., and Schröder,B. (2020)
Physiology of SPP/SPPL intramembrane proteases.
Cell Mol Life Sci. 77, 2959-2979. -
Mentrup,T., Schröder,B. (2019)
Intramembrane proteases protect from atherosclerosis.
Aging (Albany NY), 11, 8041-8043. - Kong,X.F., Martinez-Barricarte,R., Kennedy, J., Mele,F., Lazarov,T., Deenick,E.K., Ma,C.S., Breton,G., Lucero, K.B., Langlais,D., Bousfiha,A., Aytekin,C., Markle,J., Trouillet,C., Jabot-Hanin,F., Arlehamn,C.S.L., Rao,G., Picard,C., Lasseau,T., Latorre,D., Hambleton,S., Deswarte,C., Itan,Y., Abarca,K., Moraes-Vasconcelos,D., Ailal,F., Ikinciogullari,A., Dogu,F., Benhsaien,I., Sette,A., Abel,L., Boisson-Dupuis,S., Schröder,B., Nussenzweig,M.C., Liu,K., Geissmann,F., Tangye,S.G., Gros,P., Sallusto,F., Bustamante,J., Casanova, J.L. (2018)
Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nat Immunol., 19, 973-985. - Dudeck,J., Medyukhina,A., Fröbel,J., Svensson,C.M., Kotrba,J., Gerlach,M., Gradtke,A.C., Schröder,B., Speier,S., Figge,M.T., Dudeck,A. (2017)
Mast cells acquire MHCII from dendritic cells during skin inflammation. J. Exp. Med., 214, 3791-3811. - Mentrup,T., Loock,A.C., Fluhrer,R. and Schröder,B. (2017)
Signal peptide peptidase and SPP-like proteases - possible therapeutic targets? Biochim. Biophys. Acta, 1864, 2169-2182. - Schneppenheim,J., Loock,A.C., Hüttl,S., Schweizer,M., Lüllmann-Rauch,R., Oberg,H.H., Arnold,P., Lehmann,C., Dudziak,D., Kabelitz,D., Lucius,R., Lennon-Duménil,A.M., Saftig,P., and Schröder,B. (2017)
The influence of MHC class II on B cell defects induced by Invariant chain/CD74 N-terminal fragments. J. Immunol., 199, 172-185. - Nguyen,T.L., Schneppenheim,J., Rudnik,S., Lüllmann-Rauch,R., Bernreuther,C., Hermans-Borgmeyer,I., Glatzel,M., Saftig,P. and Schröder,B. (2017)
Functional characterization of the lysosomal membrane protein TMEM192 in mice. Oncotarget, 8, 43635-43652. - Mentrup,T., Fluhrer, R. and Schröder,B. (2017)
Latest emerging functions of SPP/SPPL intramembrane proteases. Eur J Cell Biol, 96, 372-382. - Schröder,B. and Saftig,P. (2016)
Intramembrane proteolysis within lysosomes. Ageing Res Rev, 32, 51-64. - Schröder,B. (2016)
The multifaceted roles of the invariant chain CD74 - More than just a chaperone. Biochim. Biophys. Acta, 1863, 1269-1281. - Hüttl,S., Helfrich,F., Mentrup,T., Held,S., Fukumori,A., Steiner,H., Saftig,P., Fluhrer,R., and Schröder,B. (2016)
Substrate determinants of Signal peptide peptidase-like 2a (SPPL2a)-mediated Intramembrane Proteolysis of the Invariant chain CD74. Biochem. J., 473, 1405-1422. - Klionsky,D.J., Abdelmohsen,K.,…, Schröder,B.,…, Zughaier, S.M. (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Autophagy, 12, 1-222. - Hüttl,S., Kläsener,K., Schweizer,M., Schneppenheim,J., Oberg,H.H., Kabelitz,D., Reth,M., Saftig,P., and Schröder,B. (2015)
Processing of CD74 by the intramembrane protease SPPL2a is critical for B cell receptor signaling in transitional B cells
J. Immunol., 195, 1548-1563. - Mentrup,T., Häsler,R., Fluhrer,R., Saftig,P., and Schröder,B. (2015)
A cell-based assay reveals nuclear translocation of intracellular domains released by SPPL proteases. Traffic, 16, 871-892. - Kuhn,P.H., Voss,M., Haug-Kröper,M., Schröder,B., Schepers,U., Bräse,S., Haass,C., Lichtenthaler,S.F., and Fluhrer,R. (2015)
Secretome analysis identifies novel signal peptide peptidase-like 3 (SPPL3) substrates and reveals a role of SPPL3 in multiple Golgi glycosylation pathways. Mol Cell Prot, 14, 1584-1598. - Voss,M., Künzel,U., Higel,F., Kuhn,P.H., Colombo,A., Fukumori,A., Haug-Kröper,M., Klier,B., Grammer,G., Seidl,A., Schröder,B., Obst,R., Steiner,H., Lichtenthaler,S.F., Haass,C., and Fluhrer,R. (2014)
Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. EMBO J, 33, 2809-2905. - Grimm,C., Holdt,L.M., Chen,C.C., Hassan,S., Müller, C., Jörs, S., Cuny,H., Kissing S., Schröder,B., Butz,E., Northoff,B., Castonguay, J., Luber,C.A., Moser,M., Spahn,S., Lüllman-Rauch,R., Fendel,C., Klugbauer,N., Griesbeck,O., Haas,A., Mann,M., Bracher,F., Teupser,D., Saftig,P., Biel,M. and Wahl-Schott,C. (2014)
High susceptibility to fatter liver disease in two-pore channel 2-deficient mice.
Nat Commun, 5, 4699. - Schneppenheim,J., Hüttl,S. Kruchen,A., Fluhrer,R. Müller,I., Saftig,P., Schneppenheim,R., Martin,C.L. and Schröder,B. (2014)
Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells. Biochem Biophys Res Commun, 451, 48-53. - Videm,P., Gunasekaran,D., Schröder,B., Mayer,B., Biniossek,M.L. and Schilling,O. (2014)
Automated Peptide Mapping and Protein-Topographical Annotation of Proteomics Data. BMC Bioinformatics, 15, 207. - Schneppenheim,J., Hüttl,S., Mentrup,T, Lüllmann-Rauch,R., Rothaug,M., Engelke,M., Dittmann,K., Dressel,R., Araki,M., Araki,K., Wienands,J., Fluhrer,R., Saftig,P. and Schröder,B. (2014)
The intramembrane proteases Signal-peptide-peptidase-like 2a/b have distinct functions in vivo. Mol Cell Biol, 34, 1398-1411. - Kraft,S., Jouvin,M.H., Kulkarni, N., Kissing,S., Morgan,E.S., Dvorak,A.M., Schröder,B., Saftig,P. and Kinet,J.P. (2013)
The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis. J. Immunol., 191, 2871-2878. - Voss,M., Schröder,B. and Fluhrer,R.(2013)
Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases. Biochim. Biophys. Acta, 1828, 2828-2839. - Bronckers,A., Güneli,N., Lüllmann-Rauch,R., Schneppenheim,J., Moraru,A.P., Himmerkus,N., Bervoets,T.J., Fluhrer, R., Everts,V., Saftig,P. and Schröder,B. (2013) The intramembrane protease SPPL2A is critical for tooth enamel formation. J Bone Miner Res, 28, 1622-1630.
- Schwake,M., Schröder,B. and Saftig,P. (2013)
Lysosomal Membrane Proteins and their central role in physiology. Traffic, 14, 739-748. - Schneppenheim,J., Dressel,R., Hüttl,S.,Lüllmann-Rauch,R., Engelke,M., Dittmann,K., Wienands,J., Eskelinen,E.L., Hermans-Borgmeyer,I., Fluhrer,R., Saftig,P., and Schröder,B. (2013)
The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain. J. Exp. Med., 210, 41-58. - Voss,M., Fukumori,A., Kuhn, P.H., Künzel, U., Klier,B., Grammer,G., Haug-Kröper,M., Kremmer,E., Lichtenthaler,S., Steiner,H., Schröder,B., Haass,C., and Fluhrer,R. (2012)
Foamy virus envelope protein is a substrate for signal peptide peptidase like-3 (SPPL3). J. Biol. Chem., 287 (52), 43401-43409. - Behnke,J., Schneppenheim,J., Koch-Nolte,F., Haag,F., Saftig,P., and Schröder,B. (2011)
Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endsosomes by a tyrosine motif in ist C-terminal tail. FEBS Lett, 585, 2951-2957. - Savalas,L.R.T., Gasnier,B., Damme,M., Lübke,T., Wrocklage,C., Debacker,C., Jézégou,A., Reinheckel,T., Hasilik,A., Saftig,P., and Schröder,B. (2011).
“Disrupted in renal carcinoma 2” (DIRC2) - a novel transporter of the lysosomal membrane - is proteolytically processed by cathepsin L. Biochem. J., 439, 113-128. - Behnke, J., Eskelinen,E.L:, Saftig,P., and Schröder,B. (2011).
Two dileucine motifs mediate late endosomal/lysosomal targeting of Transmembrane protein 192 (TMEM192) and a C-terminal cysteine residue is responsible for disulfide bond formation in TMEM192 homodimers. Biochem .J. 434, 219-231. - Saftig,P., Schröder,B., and Blanz,J. (2010).
Lysosomal membrane proteins: life between acid and neutral conditions. Biochem. Soc. Trans. 38, 1420-1423. - Schröder,B., Wrocklage,C., Hasilik,A., and Saftig,P. (2010).
The proteome of lysosomes. Proteomics 10, 4053-4076. - Schröder,B. and Saftig,P. (2010).
Molecular insights into mechanisms of intramembrane proteolysis by signal peptide peptidase (SPP). Biochem. J. 427, 1-3. - Schröder,B., Wrocklage,C., Hasilik,A., and Saftig,P. (2010).
Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane. Biol Chem. 391, 695-704. - Hasilik,A., Wrocklage,C., and Schröder,B. (2009).
Intracellular trafficking of lysosomal proteins and lysosomes. Int. J. Clin. Pharmacol. Ther. 47 (Suppl.1), S18-33. - Schieweck,O., Damme,M., Schröder,B., Hasilik,A., Schmidt,B., and Lübke,T. (2009). NCU-G1 is a highly glycosylated integral membrane protein of the lysosome. Biochem. J. 422, 83-90.
- Schröder,J., Lüllmann-Rauch,R., Himmerkus,N., Pleines,I., Nieswandt,B., Orinska,Z., Koch-Nolte,F., Schröder,B., Bleich,M., and Saftig,P. (2009).
Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function. Mol.Cell Biol. 29, 1083-1094. - Beertsen,W., Willenborg,M., Everts,V., Zirogianni,A., Podschun,R., Schröder,B., Eskelinen,E.L., and Saftig,P. (2008).
Impaired phagosomal maturation in neutrophils leads to periodontitis in lysosomal-associated membrane protein-2 knockout mice. J. Immunol. 180, 475-482. - Schröder,B., Wrocklage,C., Pan,C., Jäger,R., Kösters,B., Schäfer,H., Elsässer,H.P., Mann,M., and Hasilik,A. (2007).
Integral and Associated Lysosomal Membrane Proteins. Traffic 8, 1676-1686. - Schröder,B., Elsässer,H.P., Schmidt,B., and Hasilik,A. (2007).
Characterisation of lipofuscin-like lysosomal inclusion bodies from human placenta. FEBS Lett. 581, 102-108. - Schröder,B. and Hasilik,A. (2006).
A protocol for combined delipidation and subfractionation of membrane proteins using organic solvents. Anal. Biochem. 357, 144-146. - Melcher,R., Hillebrand,A., Bahr,U., Schröder,B., Karas,M., and Hasilik,A. (2000). Glycosylation-site-selective synthesis of N-acetyl-lactosamine repeats in bis-glycosylated human lysozyme. Biochem. J. 348, 507-515.