Publications

Recent Publications

Watts D, Janßen M, Jaykar M, Palmucci F, Weigelt M, Petzold C, Hommel A, Sparwasser T, Bonifacio E, Kretschmer K. Transient Depletion of Foxp3⁺ Regulatory T Cells Selectively Promotes Aggressive β Cell Autoimmunity in Genetically Susceptible DEREG Mice. Front Immunol. 2021 Aug 10;12:720133. doi: 10.3389/fimmu.2021.720133. eCollection 2021.PMID: 34447385

Andreas N, Potthast M, Geiselh√∂ringer AL, Garg G, de Jong R, Riewaldt J, Russkamp D, Riemann M, Girard JP, Blank S, Kretschmer K, Schmidt-Weber C, Korn T, Weih F, Ohnmacht C. RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells. J Immunol. 2019 Nov 15;203(10):2602-2613. doi: 10.4049/jimmunol.1801530. Epub 2019 Oct 2. PubMed PMID: 31578269; PubMed Central PMCID: PMC6826119.

Fischer L, Herkner C, Kitte R, Dohnke S, Riewaldt J, Kretschmer K, Garbe AI. Foxp3(+) Regulatory T Cells in Bone and Hematopoietic Homeostasis. Front Endocrinol (Lausanne). 2019 Sep 10;10:578. doi: 10.3389/fendo.2019.00578. eCollection 2019. Review. PubMed PMID: 31551927; PubMed Central PMCID: PMC6746882.

Schreiber M, Weigelt M, Karasinsky A, Anastassiadis K, Schallenberg S, Petzold
C, Bonifacio E, Kretschmer K, Hommel A. Inducible IL-7 Hyperexpression Influences
Lymphocyte Homeostasis and Function and Increases Allograft Rejection. Front
Immunol. 2019 Apr 10;10:742. doi: 10.3389/fimmu.2019.00742. eCollection 2019.
PubMed PMID: 31024566; PubMed Central PMCID: PMC6467976.

Walker TL, Schallenberg S, Rund N, Grönnert L, Rust R, Kretschmer K,
Kempermann G. T Lymphocytes Contribute to the Control of Baseline Neural
Precursor Cell Proliferation but Not the Exercise-Induced Up-Regulation of Adult
Hippocampal Neurogenesis. Front Immunol. 2018 Dec 11;9:2856. doi:
10.3389/fimmu.2018.02856. eCollection 2018. PubMed PMID: 30619254; PubMed Central
PMCID: PMC6297802.

Brennecke AM, Düber S, Roy B, Thomsen I, Garbe AI, Klawonn F, Pabst O,
Kretschmer K, Weiss S. Induced B Cell Development in Adult Mice. Front Immunol.
2018 Oct 31;9:2483. doi: 10.3389/fimmu.2018.02483. eCollection 2018. PubMed PMID:
30429851; PubMed Central PMCID: PMC6220648.

Tabansky I, Keskin DB, Watts D, Petzold C, Funaro M, Sands W, Wright P, Yunis
EJ, Najjar S, Diamond B, Cao Y, Mooney D, Kretschmer K, Stern JNH. Targeting
DEC-205(-)DCIR2(+) dendritic cells promotes immunological tolerance in
proteolipid protein-induced experimental autoimmune encephalomyelitis. Mol Med.
2018 May 3;24(1):17. doi: 10.1186/s10020-018-0017-6. PubMed PMID: 30134798;
PubMed Central PMCID: PMC6016871.

Schallenberg S, Kretschmer K. New insight into type 1 diabetes development:
resolving early diabetogenic CD4(+) T cell responses that precede seroconversion.
Ann Transl Med. 2018 Feb;6(3):58. doi: 10.21037/atm.2017.12.14. PubMed PMID:
29610749; PubMed Central PMCID: PMC5879518.

Freudenberg, K., Lindner, N., Dohnke, S., Garbe, A.I., Schallenberg, S.*, Kretschmer, K.* Critical role of TGF-β and Il-2 receptor signaling in Foxp3 induction by an inhibitor of DNA methylation. Front. Immunol. 9:125. (2018) *Equally contributing last author

Dohnke, S., Schreiber, M., Schallenberg, S., Simonetti, M., Fischer, L., Garbe, A.I., Chatzigeorgiou, A., Kretschmer, K. Approaches to discriminate naturally induced Foxp3⁺ Treg cells of intra- and extrathymic origin: Helios, Neuropilin-1, and Foxp3^RFP/GFP. J. Clin. Cell. Immunol. (in press)

Tabansky, I.*, Keskin, D.B.*, Watts,D.*, Sands, W., Petzold, C., Yunis,E.J., Cao,Y., Mooney,D., Kretschmer, K.^†,Stern, J.N.H.^†DEC-205⁻DCIR2⁺ dendritic cell targeting promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis. Molecular Medicine. (in press) ^†Corresponding and *equally contributing first author

Schallenberg, S., Kretschmer, K. New insight into type 1 diabetes development: resolving early diabetogenic CD4⁺ T cell responses that precede seroconversion. Editorial. Ann. Transl. Med. (2018) View this article at: http://dx.doi.org/10.21037/atm.2017.12.14

Fuchs, A., Gliwiński, M., Grageda, N., Spiering, R., Abbas, A.K., Appel, S., Berglund, D., Blazar, B., Bluestone, J., Kretschmer, K., Trzonkowski, P. Minimum information about T regulatory cells (MITREG): a step towards reproducibility and standardization. Front Immunol. 8:1844. (2017)

Selected Publications

Wyss, L., Stadinski, B.D., King, C.G., Schallenberg, S., McCarthy, N.I., Lee, J.Y., Kretschmer, K., Terracciano, L.M., Anderson, G., Surh, C.D., Huseby, E.S., Palmer, E. Affinity for self-antigen selects regulatory T cells with distinct functional properties. Nat. Immunol. 17(9):1093-101. (2016)

Spiering, R, Margry, B., Keijzer, C., Petzold, C., Hoek, A., Wagenaar, J., Arkesteijn, G., van der Zee, R., van Eden, W., Kretschmer, K., Broere, F. DEC-205-targeted tolerogenic vaccination promotes immune tolerance in experimental autoimmune arthritis. 2015. J. Immunol. 15,194(10):4804-13. (2015)

Warth, S.C., Hoefig, K.P., Hiekel, A., Schallenberg, S., Jovanovic, K., Klein, L., Kretschmer, K., Ansel, K.M., Heissmeyer, V. Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T cell differentiation. EMBO J. 5,34(9):1195-213 (2015)

Chmelova, H., Cohrs, C.M., Chouinard, J.A., Petzold, C., Kuhn, M., Chen, C., Roeder, I., Kretschmer, K., Speier, S. Distinct roles of beta cell mass and function during type 1 diabetes onset and remission. Diabetes. pii: db141055. (2015)

Vahl, J.C., Drees, C., Heger, K., Heink, S., Fischer, J.C., Nedjic, J., Ohkura, N., Morikawa, H., Poeck, H., Schallenberg, S., Rieß, D., Hein, M.Y., Buch, T., Polic B., Schönle, A., Zeiser, R., Schmitt-Gräff, A., Kretschmer, K., Klein, L., Korn, T., Sakaguchi, S., Schmidt-Supprian, M. Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool. Immunity. 41(5):722-736. (2014)

Mayer, C.T., Lahl, K., Dittmer, U., Fyhrquist, N., Huehn, J., Kopf, M., Kretschmer, K., Rouse, B., Sparwasser, T. Advantages of Foxp3⁺ regulatory T cell depletion using DEREG mice. Immun Inflamm Dis. 2(3): 162-165. (2014)

Petzold, C., Steinbronn, N., Gereke, M., Strasser, R., Sparwasser, T., Bruder, D., Geffers, R., Schallenberg, S., Kretschmer, K. Fluorochrome reporter-based definition of Foxp3⁺ regulatory T cell subphenotypes of distinct developmental origin. Eur. J. Immunol. 44(12):3632-45. (2014)

Xiao, S., Yosef, N., Yang, J., Wang, Y., Zhou, L., Zhu, C., Wu, C., Baloglu, E., Schmidt, D., Ramesh, R., Lobera, M., Sundrud, M.S., Tsai, P.Y., Xiang, Z., Wang, J., Xu, Y., Lin, X., Kretschmer, K., Rahl, P.B., Young, R.A., Zhong, Z., Hafler, D.A., Regev, A., Ghosh, S., Marson, A., Kuchroo, V.K. Small-Molecule ROR gamma t Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms. Immunity. 40(4):477-89. (2014)

Toker, A., Engelbert, D., Garg, G., Polansky, J.K., Floess, S., Miyao, T., Baron, U., Düber, S., Geffers, R., Giehr, P., Schallenberg, S, Kretschmer, K., Olek, S., Walter, J., Weiss, S., Hori, S., Hamann, A., Huehn, J. Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus. J Immunol. 1,190(7):3180. (2013)

Schallenberg, S., Petzold, S., Riewaldt, J., Kretschmer, K. Regulatory T Cell-Based Immunotherapy: Prospects of Antigen-Specific Tolerance Induction. In: Medical Advancements in Aging and Regenerative Technologies: Clinical Tools and Applications, ed. A. Daskalaki. IGI Global, pp. 112-136. (2013)

Petzold, C., Riewaldt, J., Watts, D., Sparwasser, T., Schallenberg, S., Kretschmer, K. Foxp3⁺ Regulatory T Cells in Mouse Models of Type 1 Diabetes. J Diabetes Res. 940710. doi: 10.1155/2013/940710. (2013)

Heninger, A.K., Theil, A., Wilhelm, C., Petzold, C., Huebel, N., Kretschmer, K., Bonifacio, E., Monti, P. IL-7 abrogates suppressive activity of human CD4⁺CD25⁺FOXP3⁺ regulatory T cells and allows expansion of alloreactive and autoreactive T cells. J Immunol. 15,189(12):5649. (2012)

Riewaldt, J., Düber, S., Boernert, M., Krey, M., Dembinski, M., Weiss, S., Garbe, A.I., Kretschmer, K. Severe developmental B lymphopoietic defects in Foxp3-deficient mice are refractory to adoptive regulatory T cell therapy. Front Immunol. 3:141. (2012)

Schallenberg, S., Petzold, C., Tsai, P.Y., Sparwasser, T., Kretschmer, K. Vagaries of fluorochrome reporter gene expression in Foxp3⁺ regulatory T cells. PLoS One. 7(8):e41971. (2012)

Petzold, C., Schallenberg, S., Stern, J.N.H., Kretschmer, K. Targeted antigen delivery to DEC-205⁺ dendritic cells for tolerogenic vaccination. Rev Diabet Stud. 2012, 9(4):305. IF: 2.5, Citations: n/a / 6

Stern, J.N.H.*^†,Keskin, D.B.*, Kato, Z., Waldner, H., Schallenberg, S., Anderson, A., von Boehmer, H., Kretschmer, K.*^†, Strominger JL^†. Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells. Proc Natl Acad Sci U S A. 107(40):17280. (2010) ^†Corresponding and *equally contributing first author

Schallenberg, S., Tsai, P.Y., Riewaldt, J., Kretschmer, K. Identification of an immediate Foxp3⁻ precursor population to Foxp3⁺ regulatory T cells in peripheral lymphoid organs of non-manipulated mice. J Exp Med. 207(7):1393. (2010)

Petzold, C., Riewaldt, J., Koenig, T., Schallenberg, S., Kretschmer K. Dendritic cell targeted pancreatic b cell antigen leads to conversion of self-reactive CD4⁺ T cells into regulatory T cells and immunotolerance in NOD mice. Rev Diabet Stud. 2010. 7(1):45. (2010)

Feuerer, M., Hill, J., Kretschmer, K., von Boehmer, H., Mathis, D., Benoist, C. Genomic definition of multiple ex vivo Treg sub-phenotypes. Proc Natl Acad Sci U S A. 30, 107 (13):5919. (2010)

Nolting, J., Daniel, C., Stuelten, C., Li, P., Sucov, H., Kim, B.G., Letterio, J.J., Kretschmer, K., Kim, H.J., von Boehmer H. Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J Exp Med. 28, 206(10):2131. (2009)

Düber, S., Hafner, M., Krey, M., Lienenklaus, S., Roy, B., Hobeika, E., Reth, M., Buch, T., Waisman, A., Weiss, S.*, Kretschmer, K.* Induction of B cell development in adult mice reveals the ability of bone marrow to produce B-1a cells. Blood. 114: 4960. (2009) *Shared senior authorship

Polansky, J.K.*, Kretschmer, K.*, Freyer, J., Floess, S., Baron, U., Garbe, A.I., Hamann, A., von Boehmer, H, Huehn, J. DNA methylation controls foxp3 gene expression. Eur. J. Immunol. 38(6): 1654. (2008) *These authors contributed equally

Kretschmer, K., Apostolou, I., Verginis, P., von Boehmer, H. Regulatory T cells and antigen-specific tolerance. Chem Immunol Allergy. 94:8. (2008)

Marson, A.*, Kretschmer, K.*, Frampton, G.M., Jacobsen, E.S., Polansky, J.K., MacIsaac, K.D., Levine, S.S., Fraenkel, E., von Boehmer, H., Young, R.A. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature. 445(7130):931. (2007) *These authors contributed equally

Kretschmer, K., Heng, T.S.P., von Boehmer, H. De novo production of antigen specific suppressor cells in vivo. Nat. Protocols. 1(2):653. (2006)

Kretschmer, K., Apostolou, I., Jaeckel, E., Khazaie, K., von Boehmer, H. Making regulatory T cells with defined antigen specificity: Role in autoimmunity and cancer. Immunol. Rev. 212:163. (2006)

Kretschmer, K., Apostolou, I., Hawiger, D., Khazaie, K., Nussenzweig, M.C., von Boehmer, H. Inducing and expanding regulatory T cells by foreign antigen. Nat. Immunol. 6: 1219. (2005)

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