Publikationen

Delgadillo-Silva LF, Akhtar MN, Taşöz E, Ninov N. Simultaneous Calcium Imaging and Glucose Stimulation in Living Zebrafish to Investigate In Vivo β-Cell Function. J Vis Exp. 2021 Sep 21;(175). doi: 10.3791/62347. PMID: 34633379

Mousavy Gharavy SN, Owen BM, Millership SJ, Chabosseau P, Pizza G, Martinez-Sanchez A, Tasoez E, Georgiadou E, Hu M, Fine NHF, Jacobson DA, Dickerson MT, Idevall-Hagren O, Montoya A, Kramer H, Mehta Z, Withers DJ, Ninov N, Gadue PJ, Cardenas-Diaz FL, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Leclerc I, Voz M, Rutter GA. Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis. Diabetologia. 2021 Apr;64(4):850-864. doi: 10.1007/s00125-020-05350-x. Epub 2021 Jan 25. PMID: 33492421

Gillotay P, Shankar M, Haerlingen B, Sema Elif E, Pozo-Morales M, Garteizgogeascoa I, Reinhardt S, Kränkel A, Bläsche J, Petzold A, Ninov N, Kesavan G, Lange C, Brand M, Lefort A, Libert F, Detours V, Costagliola S, Sumeet Pal S. Single-cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland. EMBO Rep. 2020 Dec 3;21(12):e50612. doi: 10.15252/embr.202050612. Epub 2020 Nov 3. PMID: 33140917

Rutter GA, Ninov N, Salem V, Hodson DJ. Comment on Satin et al. "Take Me To Your Leader": An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets. Diabetes 2020;69:830-836. Diabetes. 2020 Sep;69(9):e10-e11. doi: 10.2337/db20-0501. PMID: 32820056

Singh SP, Ninov N. Multicolor Labeling and Tracing of Pancreatic Beta-Cell Proliferation in Zebrafish. Methods Mol Biol. 2020;2128:159-179. doi: 10.1007/978-1-0716-0385-7_12. PMID: 32180193

Salem V, Silva LD, Suba K, Georgiadou E, Neda Mousavy Gharavy S, Akhtar N, Martin-Alonso A, Gaboriau DCA, Rothery SM, Stylianides T, Carrat G, Pullen TJ, Singh SP, Hodson DJ, Leclerc I, Shapiro AMJ, Marchetti P, Briant LJB, Distaso W, Ninov N, Rutter GA. Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo. Nat Metab. 2019 Jun;1(6):615-629. doi: 10.1038/s42255-019-0075-2. Epub 2019 Jun 14. PMID: 32694805

Dickmeis T, Feng Y, Mione MC, Ninov N, Santoro M, Spaink HP, Gut P.
Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish.
Front Cell Dev Biol. 2019 Feb 19;7:15. doi: 10.3389/fcell.2019.00015. eCollection
2019. PubMed PMID: 30873407; PubMed Central PMCID: PMC6401643.

Delgadillo-Silva LF, Tsakmaki A, Akhtar N, Franklin ZJ, Konantz J, Bewick GA,
Ninov N. Modelling pancreatic β-cell inflammation in zebrafish identifies the
natural product wedelolactone for human islet protection. Dis Model Mech. 2019
Jan 23;12(1). pii: dmm036004. doi: 10.1242/dmm.036004. PubMed PMID: 30679186;
PubMed Central PMCID: PMC6361155.

Singh SP, Janjuha S, Chaudhuri S, Reinhardt S, Kränkel A, Dietz S, Eugster A,
Bilgin H, Korkmaz S, Zararsız G, Ninov N, Reid JE. Machine learning based
classification of cells into chronological stages using single-cell
transcriptomics. Sci Rep. 2018 Nov 21;8(1):17156. doi:
10.1038/s41598-018-35218-5. PubMed PMID: 30464314; PubMed Central PMCID:
PMC6249247.

Janjuha S, Pal Singh S, Ninov N. Analysis of Beta-cell Function Using
Single-cell Resolution Calcium Imaging in Zebrafish Islets. J Vis Exp. 2018 Jul
3;(137). doi: 10.3791/57851. PubMed PMID: 30035763; PubMed Central PMCID:
PMC6102039.

Singh SP, Ninov N. The triumvirate of beta-cell regeneration: solutions and
bottlenecks to curing diabetes. Int J Dev Biol. 2018;62(6-7-8):453-464. doi:
10.1387/ijdb.180067nn. PubMed PMID: 29938757.

Janjuha S, Singh SP, Tsakmaki A, Gharavy NM, Murawala P, Konantz J, Birke S, Hodson D, Rutter G, Bewick G and Ninov N.  Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish. eLIFE . 2018

Spanjaard B, Hu B, Mitic N, Olivares-Chauvet P, Janjuha S, Ninov N, Junker J.P. Simultaneous lineage tracing and cell type identification using CRISPR/Cas9 induced genetic scars. Nature Biotechnology. 2018

So J, Khaliq M, Evason K, Ninov N, Martin BL, Stainier DYR, Shin D. Wnt/β-catenin signaling controls intrahepatic biliary network formation in zebrafish by regulating Notch activity. Hepatology. 2017 Dec 21.

Singh SP, Janjuha S, Hartmann T, Kayisoglu Ö, Konantz J, Birke S, Murawala P, Alfar EA, Murata K, Eugster A, Tsuji N, Morrissey ER, Brand M, Ninov N. Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nat Commun. 2017 Sep 22;8(1):664.

Kamel M, Ninov N. Catching new targets in metabolic disease with a zebrafish. Curr Opin Pharmacol. 2017 Dec;37:41-50.

Ahmed Alfar E, Kirova D, Konantz J, Birke S, Mansfeld J, Ninov N. Distinct Levels of Reactive Oxygen Species Coordinate Metabolic Activity with Beta-cell Mass Plasticity. Sci Rep. 2017 Jun 26;7(1):3994.

Choi TY, Khaliq M, Tsurusaki S, Ninov N, Stainier DYR, Tanaka M, Shin D. Bone morphogenetic protein signaling governs biliary-driven liver regeneration in zebrafish through tbx2b and id2a. Hepatology. 2017 Nov;66(5):1616-1630.

Ninov N, Yun MH. Current advances in tissue repair and regeneration: the future is bright. Regeneration (Oxf). 2015 Apr 23;2(2):84-91

Tsuji N, Ninov N, Delawary M, Osman S, Roh AS, Gut P, Stainier DY. Whole organism high content screening identifies stimulators of pancreatic beta-cell proliferation. PLoS One. 2014 Aug 12;9(8):e104112.

Choi TY, Ninov N, Stainier DY, Shin D. Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish. Gastroenterology. 2014 Mar;146(3):776-88.

Ninov N, Hesselson D, Gut P, Zhou A, Fidelin K, Stainier DY. Metabolic regulation of cellular plasticity in the pancreas. Curr Biol. 2013 Jul 8;23(13):1242-50.

Delous M, Yin C, Shin D, Ninov N, Debrito Carten J, Pan L, Ma TP, Farber SA, Moens CB, Stainier DY. Sox9b is a key regulator of pancreaticobiliary ductal system development. PLoS Genet. 2012;8(6):e1002754.

Ninov N, Menezes-Cabral S, Prat-Rojo C, Manjón C, Weiss A, Pyrowolakis G, Affolter M, Martín-Blanco E. Dpp signaling directs cell motility and invasiveness during epithelial morphogenesis. Curr Biol. 2010 Mar 23;20(6):513-20.

Ninov N, Borius M, Stainier DY. Different levels of Notch signaling regulate quiescence, renewal and differentiation in pancreatic endocrine progenitors. Development. 2012 May;139(9):1557-67.

Ninov N, Martín-Blanco E. Changing gears in the cell cycle: histoblasts and beyond. Fly (Austin). 2009 Oct-Dec;3(4):286-9.

Ninov N, Manjón C, Martín-Blanco E. Dynamic control of cell cycle and growth coupling by ecdysone, EGFR, and PI3K signaling in Drosophila histoblasts. PLoS Biol. 2009 Apr 7;7(4):e1000079.

Ninov N, Martín-Blanco E. Live imaging of epidermal morphogenesis during the development of the adult abdominal epidermis of Drosophila. Nat Protoc. 2007;2(12):3074-80.

Ninov N, Chiarelli DA, Martín-Blanco E. Extrinsic and intrinsic mechanisms directing epithelial cell sheet replacement during Drosophila metamorphosis. Development. 2007 Jan;134(2):367-79. Epub 2006 Dec 13.