Publications
Cachorro E, Günscht M, Schubert M, Sadek MS, Siegert J, Dutt F, Bauermeister C, Quickert S, Berning H, Nowakowski F, Lämmle S, Firneburg R, Luo X, Künzel SR, Klapproth E, Mirtschink P, Mayr M, Dewenter M, Vettel C, Heijman J, Lorenz K, Guan K, El-Armouche A, Wagner M, Kämmerer S. CNP Promotes Antiarrhythmic Effects via Phosphodiesterase 2. Circ Res. 2023 Feb 17;132(4):400-414.
Klapproth E, Witt A, Klose P, Wiedemann J, Vavilthota N, Künzel SR, Kämmerer S, Günscht M, Sprott D, Lesche M, Rost F, Dahl A, Rauch E, Kattner L, Weber S, Mirtschink P, Kopaliani I, Guan K, Lorenz K, Saftig P, Wagner M, El-Armouche A. Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction. Nat Commun. 2022 Dec 10;13(1):7648.
Klapproth E, Kämmerer S, El-Armouche A. Function and regulation of phosphatase 1 in healthy and diseased heart. Cell Signal. 2022 Feb;90:110203.
Künzel SR, Hoffmann M, Weber S, Künzel K, Kämmerer S, Günscht M, Klapproth E, Rausch JSE, Sadek MS, Kolanowski T, Meyer-Roxlau S, Piorkowski C, Tugtekin SM, Rose-John S, Yin X, Mayr M, Kuhlmann JD, Wimberger P, Grützmann K, Herzog N, Küpper JH, O'Reilly M, Kabir SN, Sommerfeld LC, Guan K, Wielockx B, Fabritz L, Nattel S, Ravens U, Dobrev D, Wagner M, El-Armouche A. (2021) Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation. Circ Res. 2021 Oct;129(8):804-820.
Wagner M, Sadek MS, Dybkova N, Mason FE, Klehr J, Firneburg R, Cachorro E, Richter K, Klapproth E, Kuenzel SR, Lorenz K, Heijman J, Dobrev D, El-Armouche A, Sossalla S, Kämmerer S. Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression. Int J Mol Sci. 2021 May 1;22(9):4816.
Kant TA, Newe M, Winter L, Hoffmann M, Kämmerer S, Klapproth E, Künzel K, Kühnel MP, Neubert L, El-Armouche A, Künzel SR. Genetic Deletion of Polo-Like Kinase 2 Induces a Pro-Fibrotic Pulmonary Phenotype. Cells. 2021 Mar 11;10(3):617.
Sadek MS, Cachorro E, El-Armouche A, Kämmerer S. Therapeutic Implications for PDE2 and cGMP/cAMP Mediated Crosstalk in Cardiovascular Diseases. Int J Mol Sci. 2020 Oct 10;21(20):7462.
Saadatmand AR, Sramek V, Weber S, Finke D, Dewenter M, Sticht C, Gretz N, Wüstemann T, Hagenmueller M, Künzel S, Meyer-Roxlau S, Kramer M, Sossalla S, Lehmann LH, Kämmerer S, Backs J, El-Armouche A (2019) CaM Kinase II regulates cardiac hemoglobin expression through histone phosphorylation upon sympathetic activation. Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22282-22287.
Künzel SR, Schaeffer C, Sekeres K, Mehnert CS, Schacht Wall SM, Newe M, Kämmerer S, El-Armouche A. Ultrasonic-augmented Primary Adult Fibroblast Isolation. J Vis Exp. 2019; 149.
Belau F, Metzner K, Christ T, Ravens U, Schaefer M, Künzel S, Li W, Wettwer E, Dobrev D, El-Armouche A, Kämmerer S. DPP10 is a new regulator of Nav1.5 channels in human heart. Int J Cardiol. 2019; 284:68-73.
Singh S, Lämmle S, Giese H, Kämmerer S, Meyer-Roxlau S, Alfar EA, Dihazi H, Guan K, El-Armouche A, Richter F. The reduced activity of PP-1α under redox stress condition is a consequence of GSH-mediated transient disulfide formation. Sci Rep. 2018; 8(1):17711.
Turnow K, Metzner K, Cotella D, Morales MJ, Schaefer M, Christ T, Ravens U, Wettwer E and Kämmerer S. Interaction of DPP10a with Kv4.3 channel complex results in a sustained current component of human transient outward current Ito. Basic Res Cardiol. 2015;110:5.
Radicke S, Riedel T, Cotella D, Turnow K, Ravens U, Schaefer M, Wettwer E. Accessory subunits alter the temperature sensitivity of Kv4.3 channel complexes. J Mol Cell Cardiol. 2013;56:8-18.
Krügel U, Fischer J, Radicke S, Sack U, Himmerich H. Antidepressant effects of TNF-α blockade in an animal model of depression. J Psychiatr Res. 2013;47(5):611-6.
Cotella D, Radicke S, Cipriani V, Cavaletto M, Merlin S, Follenzi A, Ravens U, Wettwer E, Santoro C, Sblattero D. N-glycosylation of the mammalian dipeptidyl aminopeptidase-like protein 10 (DPP10) regulates trafficking and interaction with Kv4 channels. Int J Biochem Cell Biol. 2012;44(6):876-85.
Cotella D, Radicke S, Bortoluzzi A, Ravens U, Wettwer E, Santoro C, Sblattero D. Impaired glycosylation blocks DPP10 cell surface expression and alters the electrophysiology of Ito channel complex. Pflugers Arch. 2010;460(1):87-97.
Radicke S, Cotella D, Sblattero D, Ravens U, Santoro C, Wettwer E. The transmembrane beta-subunits KCNE1, KCNE2, and DPP6 modify pharmacological effects of the antiarrhythmic agent tedisamil on the transient outward current Ito. Naunyn Schmiedebergs Arch Pharmacol. 2009;379(6):617-26.
Christ T, Wettwer E, Voigt N, Hála O, Radicke S, Matschke K, Várro A, Dobrev D, Ravens U. Pathology-specific effects of the IKur/Ito/IK,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation. Br J Pharmacol. 2008;154(8):1619-30.
Radicke S, Vaquero M, Caballero R, Gómez R, Núñez L, Tamargo J, Ravens U, Wettwer E, Delpón E. Effects of MiRP1 and DPP6 beta-subunits on the blockade induced by flecainide of Kv4.3/KChIP2 channels. Br J Pharmacol. 2008;154(4):774-86.
Radicke S, Cotella D, Graf EM, Banse U, Jost N, Varró A, Tseng GN, Ravens U, Wettwer E. Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts. Cardiovasc Res. 2006;1;71(4):695-703.
Radicke S, Cotella D, Graf EM, Ravens U, Wettwer E. Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3. J Physiol. 2005;15;565(Pt 3):751-6.
Cotella D, Jost N, Darna M, Radicke S, Ravens U, Wettwer E. Silencing the cardiac potassium channel Kv4.3 by RNA interference in a CHO expression system. Biochem Biophys Res Commun. 2005;6;330(2):555-60.