Total synthesis
In the Plietker-group, a number of complex total syntheses of natural and active substances have been successfully completed in recent years.
Many of these natural products exhibit interesting biological activities. However, it is the declared goal of total synthetic research to develop access natural substances in a few steps (max. 10 - 12 steps) and making substituent variations very easy on the molecular structure. With these basic requirements, the natural substances shown are to be further developed in future work in cooperation with groups from biology and medicine for specific indications. The fact that this can be achieved has been shown in recent years based on the systematic evaluation of the structure-activity relationships of polycyclic polyprenylated acylphloroglucinols (PPAP).