Publications

2025

• Small-molecule dissolution of stress granules by redox modulation benefits ALS modelsUechi, H., Sridharan, S., Nijssen, J., Bilstein, J., Iglesias-Artola, J. M., Kishigami, S., Casablancas-Antras, V. & 30 others, Oct 2025, In: Nature chemical biology. 21, 10, p. 1577–1588, 12 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Current practices in the study of biomolecular condensates: a community commentAlberti, S., Arosio, P., Best, R. B., Boeynaems, S., Cai, D., Collepardo-Guevara, R., Dignon, G. L. & 27 others, 19 Aug 2025, In: Nature communications. 16, 1, 7730Electronic (full-text) versionResearch output: Contribution to journal > Comment/Debate
• Quantifying collective interactions in biomolecular phase separationAusserwöger, H., de Csilléry, E., Qian, D., Krainer, G., Welsh, T. J., Sneideris, T., Franzmann, T. M. & 9 others, 19 Aug 2025, In: Nature communications. 16, 1, 7724Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregatesYan, X., Kuster, D., Mohanty, P., Nijssen, J., Pombo-García, K., Garcia Morato, J., Rizuan, A. & 18 others, 24 Jul 2025, In: Cell. 188, 15, p. 4123-4140.e18Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Aldolase-regulated G3BP1/2+ condensates control insulin mRNA storage in beta cellsQuezada, E., Knoch, K., Vasiljevic, J., Seiler, A., Pal, A., Gunasekaran, A., Münster, C. & 14 others, 1 Jul 2025, In: The EMBO journal. 44 (2025), 13, p. 3669-3696, 28 p., 107469Electronic (full-text) versionResearch output: Contribution to journal > Research article
• SHARK-capture identifies functional motifs in intrinsically disordered protein regionsChow, C. F. W., Lenz, S., Scheremetjew, M., Ghosh, S., Richter, D., Jegers, C., von Appen, A. & 2 others, Apr 2025, In: Protein science. 34, 4, e70091Electronic (full-text) versionResearch output: Contribution to journal > Research article
• SUMO2/3 conjugation of TDP-43 protects against aggregationVerde, E. M., Antoniani, F., Mediani, L., Secco, V., Crotti, S., Ferrara, M. C., Vinet, J. & 19 others, 21 Feb 2025, In: Science advances. 11, 8, eadq2475Electronic (full-text) versionResearch output: Contribution to journal > Research article
• G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatabilityTrussina, I. R. E. A., Hartmann, A., Desroches Altamirano, C., Natarajan, J., Fischer, C. M., Aleksejczuk, M., Ausserwöger, H. & 4 others, 6 Feb 2025, In: Molecular cell. 85 (2025), 3, p. 585-601.e11, 28 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Molecular determinants of condensate compositionHolehouse, A. S. & Alberti, S., 16 Jan 2025, In: Molecular Cell. 85, 2, p. 290-308, 19 p.Electronic (full-text) versionResearch output: Contribution to journal > Review article
• Surviving the heat: the role of macromolecular assemblies in promoting cellular shutdownDesroches Altamirano, C. & Alberti, S., 2 Jan 2025, In: Trends in Biochemical Sciences. 50, 1, p. 18-32, 15 p.Electronic (full-text) versionResearch output: Contribution to journal > Review article

2024

• Optical characterization of molecular interaction strength in protein condensatesBeck, T. A., van der Linden, L., Borcherds, W. M., Kim, K., Schlüßler, R., Müller, P., Franzmann, T. M. & 6 others, 1 Dec 2024, In: Molecular Biology of the Cell. 35, 12, 15 p., ar154Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Chemical inhibition of the integrated stress response impairs the ubiquitin-proteasome systemXu, S., Gierisch, M. E., Barchi, E., Poser, I., Alberti, S., Salomons, F. A. & Dantuma, N. P., 8 Oct 2024, In: Communications biology. 7 (2024), 1, 11 p., 1282Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Protocol to reconstitute translationally arrested heat shock mRNPs and condensates in vitroDesroches Altamirano, C. & Alberti, S., 20 Sep 2024, In: STAR Protocols. 5, 3, 103275Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Single-molecule digital sizing of proteins in solutionKrainer, G., Jacquat, R. P., Schneider, M. M., Welsh, T. J., Fan, J., Peter, Q. A., Andrzejewska, E. A. & 8 others, 4 Sep 2024, In: Nature Communications. 15, 7740Electronic (full-text) versionResearch output: Contribution to journal > Research article
• eIF4F is a thermo-sensing regulatory node in the translational heat shock responseDesroches Altamirano, C., Kang, M. K., Jordan, M. A., Borianne, T., Dilmen, I., Gnädig, M., von Appen, A. & 3 others, 2 May 2024, In: Molecular cell. 84 (2024), 9, p. 1727-1741, 27 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
• PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA endsChappidi, N., Quail, T., Doll, S., Vogel, L. T., Aleksandrov, R., Felekyan, S., Kühnemuth, R. & 6 others, 15 Feb 2024, In: Cell. 187, 4, p. 945-961.e18, 35 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article

2023

• Biomolecular condensates in kidney physiology and diseaseGao, G., Sumrall, E. S., Pitchiaya, S., Bitzer, M., Alberti, S. & Walter, N. G., Dec 2023, In: Nature Reviews. Nephrology. 19, 12, p. 756-770, 15 p.Electronic (full-text) versionResearch output: Contribution to journal > Review article
• Human Small Heat Shock Protein B8 Inhibits Protein Aggregation without Affecting the Native Folding ProcessChoudhary, D., Mediani, L., Avellaneda, M. J., Bjarnason, S., Alberti, S., Boczek, E. E., Heidarsson, P. O. & 4 others, 19 Jul 2023, In: Journal of the American Chemical Society. 145, 28, p. 15188-15196, 9 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
• A shared fate for nuclear and cytosolic inclusionsAlberti, S. & Carra, S., May 2023, In: Nature cell biology. 25, 5, p. 629-630, 2 p.Electronic (full-text) versionResearch output: Contribution to journal > Comment/Debate
• Direct digital sensing of protein biomarkers in solutionKrainer, G., Saar, K. L., Arter, W. E., Welsh, T. J., Czekalska, M. A., Jacquat, R. P. B., Peter, Q. & 11 others, 6 Feb 2023, In: Nature communications. 14, 653Electronic (full-text) versionResearch output: Contribution to journal > Research article

2022

• Cytosolic stress granules relieve the ubiquitin-proteasome system in the nuclear compartmentXu, S., Gierisch, M. E., Schellhaus, A. K., Poser, I., Alberti, S., Salomons, F. A. & Dantuma, N. P., 27 Dec 2022, In: EMBO Journal. 42 (2023), 3, 19 p., e111802Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Biomolecular condensate phase diagrams with a combinatorial microdroplet platformArter, W. E., Qi, R., Erkamp, N. A., Krainer, G., Didi, K., Welsh, T. J., Acker, J. & 10 others, 21 Dec 2022, In: Nature communications. 13, 1, 7845Electronic (full-text) versionResearch output: Contribution to journal > Research article
• SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNAMaharana, S., Kretschmer, S., Hunger, S., Yan, X., Kuster, D., Traikov, S., Zillinger, T. & 16 others, 6 Oct 2022, In: Molecular cell. 82, 19, p. 3712-3728.e1-e10, 28 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
• CAPRIN1^P512L causes aberrant protein aggregation and associates with early-onset ataxiaDelle Vedove, A., Natarajan, J., Zanni, G., Eckenweiler, M., Muiños-Bühl, A., Storbeck, M., Guillén Boixet, J. & 10 others, 22 Sep 2022, In: Cellular and Molecular Life Sciences. 79, 10, 526Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutionsKar, M., Dar, F., Welsh, T. J., Vogel, L. T., Kühnemuth, R., Majumdar, A., Krainer, G. & 6 others, 12 Jul 2022, In: Proceedings of the National Academy of Sciences of the United States of America : PNAS. 119, 28, e2202222119Electronic (full-text) versionResearch output: Contribution to journal > Research article