Publications

2021

• Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signalingMediani, L., Antoniani, F., Galli, V., Vinet, J., Carrà, A. D., Bigi, I., Tripathy, V. & 16 others, 5 May 2021, In: EMBO reports. 22, 5, e51740Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Protein products of nonstop mRNA disrupt nucleolar homeostasisDavis, Z. H., Mediani, L., Antoniani, F., Vinet, J., Li, S., Alberti, S., Lu, B. & 3 others, May 2021, In: Cell stress & chaperones. 26, 3, p. 549-561, 13 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Reciprocal regulation of cellular mechanics and metabolismEvers, T. M. J., Holt, L. J., Alberti, S. & Mashaghi, A., Apr 2021, In: Nature metabolism. 3, 4, p. 456-468, 13 p.Electronic (full-text) versionResearch output: Contribution to journal > Review article
• Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageingAlberti, S. & Hyman, A. A., Mar 2021, In: Nature Reviews Molecular Cell Biology. 22, 3, p. 196-213, 18 p.Electronic (full-text) versionResearch output: Contribution to journal > Review article
• Reentrant Liquid Condensate Phase of Proteins is Stabilized by Hydrophobic and Non-Ionic interactionsKrainer, G., Welsh, T. J., Joseph, J. A., St George-Hyslop, P., Hyman, A. A., Collepardo-Guevara, R., Alberti, S. & 1 others, 12 Feb 2021, In: Biophysical journal. 120, 3, p. 28A-28AResearch output: Contribution to journal > Meeting abstract
• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹Collaborators, Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S. & 45 others, Jan 2021, In: Autophagy. 17, 1, p. 1-382, 382 p.Electronic (full-text) versionResearch output: Contribution to journal > Review article

2020

• Protein phase separation and its role in tumorigenesisJiang, S., Fagman, J. B., Chen, C., Alberti, S. & Liu, B., 3 Nov 2020, In: eLife. 9Electronic (full-text) versionResearch output: Contribution to journal > Review article
• BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomesMediani, L., Galli, V., Carra, A. D., Bigi, I., Vinet, J., Ganassi, M., Antoniani, F. & 8 others, Nov 2020, In: Cell stress & chaperones. 25, 6, p. 1045-1058, 14 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transitionShen, Y., Ruggeri, F. S., Vigolo, D., Kamada, A., Qamar, S., Levin, A., Iserman, C. & 3 others, 1 Oct 2020, In: Nature nanotechnology. 15, 10, p. 841-847, 7 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
• The plant response to heat requires phase separationAlberti, S., 10 Sep 2020, In: Nature. 585, 7824, p. 191-192Research output: Contribution to journal > Editorial (Lead article)
• The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress GranulesKeiten-Schmitz, J., Wagner, K., Piller, T., Kaulich, M., Alberti, S. & Mueller, S., 2 Jul 2020, In: Molecular cell. 79, 1, p. 54-67.e7Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Filament formation by the translation factor eIF2B regulates protein synthesis in starved cellsNuske, E., Marini, G., Richter, D., Leng, W., Bogdanova, A., Franzmann, T. M., Pigino, G. & 1 others, Jul 2020, In: Biology open. 9, 7, bio046391Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Reorganization of budding yeast cytoplasm upon energy depletionMarini, G., Nueske, E., Leng, W., Alberti, S. & Pigino, G., 1 Jun 2020, In: Molecular Biology of the Cell. 31, 12, p. 1232-1245, 14 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein ProductionIserman, C., Altamirano, C. D., Jegers, C., Friedrich, U., Zarin, T., Fritsch, A. W., Mittasch, M. & 12 others, 14 May 2020, In: Cell. 181, 4, p. 818-831.e19Electronic (full-text) versionResearch output: Contribution to journal > Research article
• RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by CondensationGuillén-Boixet, J., Kopach, A., Holehouse, A. S., Wittmann, S., Jahnel, M., Schlüßler, R., Kim, K. & 16 others, 16 Apr 2020, In: Cell. 181, 2, p. 346-361.e17Electronic (full-text) versionResearch output: Contribution to journal > Research article
• ALS and FTD: Where RNA metabolism meets protein quality controlMandrioli, J., Mediani, L., Alberti, S. & Carra, S., Mar 2020, In: Seminars in cell & developmental biology. 99, p. 183-192Electronic (full-text) versionResearch output: Contribution to journal > Review article

2019

• Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteinsMediani, L., Guillen-Boixet, J., Alberti, S. & Carra, S., 2 Nov 2019, In: MOLECULAR & CELLULAR ONCOLOGY. 6, 6, e1415624Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Nucleolus: A Liquid Droplet Compartment for Misbehaving ProteinsAlberti, S. & Carra, S., 7 Oct 2019, In: Current biology. 29, 19, p. R930-R932Electronic (full-text) versionResearch output: Contribution to journal > Editorial (Lead article)
• Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitinMediani, L., Guillen-Boixet, J., Vinet, J., Franzmann, T. M., Bigi, I., Mateju, D., Carra, A. D. & 5 others, 1 Aug 2019, In: The EMBO journal. 38, 15Research output: Contribution to journal > Research article
• Proteome-wide signatures of function in highly diverged intrinsically disordered regionsZarin, T., Strome, B., Ba, A. N. N., Alberti, S., Forman-Kay, J. D. & Moses, A. M., 2 Jul 2019, In: eLife. 8, e46883Electronic (full-text) versionResearch output: Contribution to journal > Research article
• FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagyMarrone, L., Drexler, H. C., Wang, J., Tripathi, P., Distler, T., Heisterkamp, P., Anderson, E. N. & 21 others, 1 Jul 2019, In: Acta neuropathologica. 138, 1, p. 67-84, 18 p.Electronic (full-text) versionResearch output: Contribution to journal > Research article
• The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivoVijayakumar, J., Perrois, C., Heim, M., Bousset, L., Alberti, S. & Besse, F., 13 Jun 2019, In: Nature communications. 10, 2593Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Protein Phase Separation as a Stress Survival StrategyFranzmann, T. M. & Alberti, S., Jun 2019, In: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 9, 6, a034058Electronic (full-text) versionResearch output: Contribution to journal > Research article
• Prion-like low-complexity sequences: Key regulators of protein solubility and phase behaviorFranzmann, T. M. & Alberti, S., 3 May 2019, In: Journal of Biological Chemistry. 294, 18, p. 7128-7136Electronic (full-text) versionResearch output: Contribution to journal > Review article
• Small heat shock proteins: multifaceted proteins with important implications for lifeCarra, S., Alberti, S., Benesch, J. L., Boelens, W., Buchner, J., Carver, J. A., Cecconi, C. & 13 others, 1 Mar 2019, In: Cell Stress and Chaperones. 24, 2, p. 295-308, 14 p.Electronic (full-text) versionResearch output: Contribution to journal > Review article